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The purpose of this research project was to explore doctoral student learning and development as scholarly practitioners through one innovative method: a course-based self-study. This self-study empowered doctoral candidates in three key forms of data collection: 1) two project-based course assignments; 2) a survey on course-based student learning; and 3) a self-reflection on learning in the self-study. Results indicate positive impacts in addressing real-life problems and in connecting students to cohort members. The application of skills and knowledge in a course-embedded self-study connects to the Carnegie Project on the Education Doctorate (CPED) principles of creating scholarly practitioners and also developing activist leaders who build coalitions and focus on researching real life social justice issues. This study can serve as an exemplar for similar EdD programs who are developing scholarly practitioners.

The last two decades have seen institutions of higher education put increasing emphasis on both internationalizing their institutions and making them more sustainable. While laudable in their own right, there are contradictions and tensions between these goals, in particular when the carbon emissions involved in international activities like study abroad are considered. But there is also potential synergy between these goals. In this article, the authors explore two case studies of programs abroad that seriously engaged both the contradictions and opportunities inherent in the idea of sustainable international education. The first examines environmental politics and ecology in New Zealand and the Cook Islands and the second compares sustainable urban practices in Canada and the United States. Based on the lessons learned from these case studies, the authors argue that partnership between internationalization and sustainability efforts is necessary to help institutions of higher learning become both global and "green." To that effect, the authors discuss specific and concrete ways to "green" study abroad courses throughout this article, particularly within the two case studies and in their concluding discussion of strategies for international educators, faculty, and higher education administrators. (Contains 2 notes.)

The authors describe their experiences teaching Sustainable Cities in North America, a course on both urban sociology and urban sustainability. This course brought students to Portland, Oregon, and Vancouver, British Columbia, and then compared those cities with Minneapolis, Minnesota, on various dimensions of urban sustainability. After connecting this course to existing sociological scholarship on teaching urban sociology and travel-study abroad, the authors describe their course "in action": what they did, why it was (and was not) "green," and an assessment of the course, including postcourse actions and institutional changes that the course inspired. The authors conclude with a call for more "green" sociology courses and travel-study abroad courses as innovative and exciting ways to teach sociology and to further the discipline's commitment to ethical environmental actions.

This ethnographic study aimed at developing a richer understanding of how youth, their schools, and the communities in which they are emplaced coincide to generate a set of local social processes that affect marijuana use. We trace the interplay between high school staff and students with regards to marijuana use in the proximity of a local high school and the shifting geographies of use in this setting. Although marijuana use was a concern for teachers and administrators, they seemed unaware of how their strategies tended to reinforce use among teens. In and around the physical space of the school, social spaces for marijuana use were co-created by the actions of students and teachers. Groups of students would leave the school and smoke marijuana in school time. Students were aware that they needed to keep their use discrete. Teachers and staff unintentionally conveyed the message that marijuana use was acceptable provided it did not take place on school property. Students and staff thus enacted and reinforced the barriers to open communication about marijuana use. The teen appropriation of space to use marijuana can be interpreted as a counter-positioning of youth and adult norms. (Contains 1 figure and 2 notes.)

This article introduces a curricular innovation, the Integrated Health Scholars Program (IHSP), developed to prepare master's-level social work students for practice in integrated health care settings, and presents preliminary findings related to students' self-reported program competencies and perceptions. IHSP, implemented in a research-intensive school of social work in a large midwestern public university, includes specialized course work, interprofessional education across health science disciplines, and field practicum in integrated health care settings. Curricular components support stepwise learning and follows the British Columbia model of interprofessional education learning tiers: exposure, immersion, and skill mastery. Despite IHSPs successful development in a well-resourced, supportive environment, challenges facing our profession's ability to develop and sustain training of MSW students in integrated health care are discussed.

Importance: To our knowledge, no study has previously evaluated whether individuals with bipolar depression enriched a priori on the basis of biochemical and/or phenotypic immuno-inflammatory activation would differentially respond to an anti-inflammatory agent for the treatment of depressive symptoms.Objective: To assess the antidepressant efficacy of adjunctive infliximab, a monoclonal antibody targeting tumor necrosis factor, in adults with bipolar I and bipolar II depression and inflammatory conditions.Design, Setting, and Participants: This 12-week, randomized, double-blind, placebo-controlled, parallel-group trial of 60 participants was conducted at 2 outpatient tertiary care sites in Canada and the United States. Eligible adults (aged 18-65 years) met DSM-5-defined criteria for bipolar I or bipolar II depression and exhibited pretreatment biochemical and/or phenotypic evidence of inflammatory activation. Participants were enrolled between October 1, 2015, and April 30, 2018. Data analysis was performed from May 1 through July 31, 2018, using modified intent-to-treat analysis.Interventions: Patients were randomized to receive 3 intravenous infusions of infliximab therapy or placebo at baseline and at weeks 2 and 6 of the 12-week study.Main Outcomes and Measures: The primary efficacy outcome was baseline-to-end point (ie, week-12) change in Montgomery-Asberg Depression Rating Scale (MADRS) total score. History of childhood maltreatment, as assessed by the Childhood Trauma Questionnaire, was used for exploratory analyses as 1 of several secondary outcomes.Results: A total of 60 participants were randomized to infliximab (n = 29 [48%]; mean [SD] age, 45.0 [11.7] years; 20 of 28 female [71%]) or to placebo (n = 31 [52%]; mean [SD] age, 46.8 [10.2] years; 26 of 30 female [87%]) across study sites. Overall baseline-to-end point change in MADRS total score was observed across treatment × time interaction (χ2 = 10.33; P = .04); reduction in symptom severity was not significant at week 12 (relative risk, 1.09; 95% CI, 0.80-1.50; df = 1; P = .60). As part of a secondary analysis, a significant treatment × time × childhood maltreatment interaction was observed in which infliximab-treated individuals with childhood history of physical abuse exhibited greater reductions in MADRS total score (χ2 = 12.20; P = .02) and higher response rates (≥50% reduction in MADRS total score) (χ2 = 4.05; P = .04).Conclusions and Relevance: Infliximab did not significantly reduce depressive symptoms compared with placebo in adults with bipolar depression. Results from secondary analyses identified a subpopulation (ie, those reporting physical and/or sexual abuse) that exhibited a significant reduction in depressive symptoms with infliximab treatment compared with placebo.Trial Registration: ClinicalTrials.gov identifier: NCT02363738. [ABSTRACT FROM AUTHOR]

Importance: The extent of dorsolateral prefrontal cortex (DLPFC) plasticity in Alzheimer disease (AD) and its association with working memory are not known.Objectives: To determine whether participants with AD had impaired DLPFC plasticity compared with healthy control participants, to compare working memory between participants with AD and controls, and to determine whether DLPFC plasticity was associated with working memory.Design, Setting, and Participants: This cross-sectional study included 32 participants with AD who were 65 years or older and met diagnostic criteria for dementia due to probable AD with a score of at least 17 on the Mini-Mental State Examination and 16 age-matched control participants. Participants were recruited from a university teaching hospital from May 2013 to October 2016.Main Outcomes and Measures: Plasticity of the DLPFC measured as potentiation of cortical-evoked activity using paired associative stimulation (a combination of peripheral nerve electrical stimulation and transcranial magnetic stimulation) combined with electroencephalography. Working memory was assessed with the n-back task (1- and 2-back) and measured using the A' statistic.Results: Among the 32 participants with AD, 17 were women and 15 were men (mean [SD] age, 76.3 [6.3] years); among the 16 controls, 8 were men and 8 were women (mean [SD] age, 76.4 [5.1] years). Participants with AD had impaired DLPFC plasticity (mean [SD] potentiation, 1.18 [0.25]) compared with controls (mean [SD] potentiation, 1.40 [0.35]; F1,44 = 5.90; P = .02; between-group comparison, Cohen d = 0.77; P = .01). Participants with AD also had impaired performances on the 1-back condition (mean [SD] A' = 0.47 [0.30]) compared with controls (mean [SD] A' = 0.96 [0.01]; Cohen d = 1.86; P < .001), with similar findings for participants with AD on the 2-back condition (mean [SD] A' = 0.29 [0.2]) compared with controls (mean [SD], A' = 0.85 [0.18]; Cohen d = 2.83; P < .001). Plasticity of DLPFC was positively associated with working memory performance on the 1-back A' (parameter estimate B [SE] = 0.32 [0.13]; standardized β = 0.29; P = .02) and 2-back A' (B [SE] = 0.43 [0.15]; β = 0.39; P = .006) across both groups after controlling for age, education, and attention.Conclusions and Relevance: This study demonstrated impaired in vivo DLPFC plasticity in patients with AD. The findings support the use of DLPFC plasticity as a measure of DLPFC function and a potential treatment target to enhance DLPFC function and working memory in patients with AD. [ABSTRACT FROM AUTHOR]

Research suggests that women's drug use commonly has distinct dynamics and features which require specific understanding. The present study assesses gender differences in cannabis use characteristics among a sample of high frequency cannabis users drawn from a Canadian full-time university student population. 134 respondents (32.8% female), who used cannabis at least three times per week in the past 12 weeks, were recruited from two universities in Toronto, Canada. Women were more likely to have three or more cannabis episodes per day in the past 30 days compared to men (43.2% versus 18.9%) and were also more likely to use cannabis for medical reasons (65.9% versus 46.7%). In this sample, women high-frequency cannabis users indicated more intensive use and problem patterns which reflect gendered observations from other studies. These finding highlight the need for more research exploring these gender differences as well as consideration for targeted intervention practices. [ABSTRACT FROM AUTHOR]

The article discusses a study which identified the prescription pattern and safety profile for irreversible monoamine oxidase inhibitors (MAOI) in older adults in Canada. The study explored the prevalence and incidence of irreversible MAOI use and the frequency of coprescribing MAOI with contraindicated medications between January 1, 1997 and April 14, 2007. It found that MAOI are underprescribed and underutilized in patients with atypical depression and treatment-refractory depression.

Copyright of Canadian Journal of Public Health is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Canadian Journal of Public Health is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Canadian Journal of Public Health is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)