1. Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC.
- Author
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Montine TJ, Li K, Perl DP, and Galasko D
- Subjects
- Aged, Alzheimer Disease chemically induced, Alzheimer Disease physiopathology, Amino Acids, Diamino analysis, Amyotrophic Lateral Sclerosis chemically induced, Amyotrophic Lateral Sclerosis physiopathology, Brain pathology, Brain physiopathology, Brain Chemistry physiology, Canada, Cyanobacteria Toxins, Environmental Exposure, Female, Guam, Humans, Male, Middle Aged, Parkinsonian Disorders chemically induced, Parkinsonian Disorders physiopathology, Reproducibility of Results, Alzheimer Disease metabolism, Amino Acids, Diamino metabolism, Amyotrophic Lateral Sclerosis metabolism, Brain metabolism, Parkinsonian Disorders metabolism
- Abstract
High levels of beta-methylamino-l-alanine (BMAA), a putative neurotoxin, have been reported in brain samples from Chamorros and patients with Alzheimer disease (AD) from western Canada. The authors assayed free BMAA in the brains of five control subjects and five patients with AD from the US Pacific Northwest as well as Chamorros with and without Parkinson-dementia complex. In contrast to others, they detected no free BMAA in any of these samples.
- Published
- 2005
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