1. A large Canadian cohort provides insights into the genetic architecture of human hair colour.
- Author
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Lona-Durazo F, Mendes M, Thakur R, Funderburk K, Zhang T, Kovacs MA, Choi J, Brown KM, and Parra EJ
- Subjects
- Adult, Canada, Cohort Studies, Cyclin-Dependent Kinases metabolism, Female, Humans, Male, Middle Aged, Quantitative Trait Loci, Receptor, Endothelin B metabolism, Cyclin-Dependent Kinases genetics, Genome-Wide Association Study, Hair Color genetics, Receptor, Endothelin B genetics
- Abstract
Hair colour is a polygenic phenotype that results from differences in the amount and ratio of melanins located in the hair bulb. Genome-wide association studies (GWAS) have identified many loci involved in the pigmentation pathway affecting hair colour. However, most of the associated loci overlap non-protein coding regions and many of the molecular mechanisms underlying pigmentation variation are still not understood. Here, we conduct GWAS meta-analyses of hair colour in a Canadian cohort of 12,741 individuals of European ancestry. By performing fine-mapping analyses we identify candidate causal variants in pigmentation loci associated with blonde, red and brown hair colour. Additionally, we observe colocalization of several GWAS hits with expression and methylation quantitative trait loci (QTLs) of cultured melanocytes. Finally, transcriptome-wide association studies (TWAS) further nominate the expression of EDNRB and CDK10 as significantly associated with hair colour. Our results provide insights on the mechanisms regulating pigmentation biology in humans., (© 2021. The Author(s).)
- Published
- 2021
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