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1. Fosfomycin resistance mediated by fos genes remains rare among extended-spectrum beta-lactamase-producing Escherichia coli clinical isolates recovered from the urine of patients evaluated at Canadian hospitals (CANWARD, 2007-2017).

Author

Walkty A, Karlowsky JA, Baxter MR, Adam HJ, Alexander D, Bay DC, Boyd D, McCracken M, Mulvey MR, and Zhanel GG

Subjects
Canada, Drug Resistance, Bacterial genetics, Escherichia coli enzymology, Escherichia coli Infections microbiology, Hospitals statistics & numerical data, Humans, Microbial Sensitivity Tests, beta-Lactamases genetics, Anti-Bacterial Agents pharmacology, Escherichia coli drug effects, Escherichia coli genetics, Escherichia coli Infections urine, Fosfomycin pharmacology, Genes, fos, Urinary Tract Infections microbiology
Abstract

Among 162 isolates of extended-spectrum beta-lactamase-(ESBL)-producing Escherichia coli recovered from the urine of Canadian patients (2007-2017), five (3.1%) were not susceptible in vitro to fosfomycin (MIC ≥128 μg/mL). These isolates underwent whole genome sequencing to assess for the presence of fos genes. The fosA3 gene was detected in one isolate., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Published
2020
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