1. The use of benzodiazepine hypnotics in the elderly.
- Author
-
Baker MI and Oleen MA
- Subjects
- Adolescent, Age Factors, Aged, Aged, 80 and over, Canada, Drug Interactions, Drug Prescriptions, Drug Utilization, Female, Flurazepam therapeutic use, Humans, Male, Oxazepam therapeutic use, Prospective Studies, Triazolam therapeutic use, Flurazepam administration & dosage, Oxazepam administration & dosage, Sleep Initiation and Maintenance Disorders drug therapy, Triazolam administration & dosage
- Abstract
An epidemiologic study was conducted to observe patient-reported use and effects of triazolam, flurazepam, and oxazepam taken at bedtime among 2260 outpatients age 65 years or older in Canada. The study used pharmacy-based enrollment, with participant follow-up through a 3-day diary and a telephone interview. The study also evaluated how the three benzodiazepine hypnotics were prescribed. Prescription information showed that 66% of the flurazepam prescriptions were for the highest strength, compared to 39% and 35% for triazolam and oxazepam, respectively. As patient age increased, the highest strength of each agent was prescribed less frequently. For all drugs, 53% of prescriptions were written for use as necessary (prn), and the proportion who received such prescriptions increased with age. Patient reports, however, revealed that 57% were using a hypnotic every day, and this regular use increased with advancing age. Regular daily use was more common among those who used triazolam and oxazepam (62%) than those who took flurazepam (42%).
- Published
- 1988
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