1. How is ceftobiprole used in Canada: the CLEAR study final results.
- Author
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Zhanel GG, Kosar J, Baxter M, Dhami R, Borgia S, Irfan N, Dow G, Dube M, von den Baumen TR, Tascini C, Lee A, Chagla Z, Girouard G, Bourassa-Blanchette S, Wu M, Keynan Y, Walkty A, and Karlowsky JA
- Subjects
- Humans, Canada, Registries, Methicillin-Resistant Staphylococcus aureus drug effects, Community-Acquired Infections drug therapy, Community-Acquired Infections microbiology, Cross Infection drug therapy, Cross Infection microbiology, Bacterial Infections drug therapy, Bacterial Infections microbiology, Daptomycin pharmacology, Daptomycin administration & dosage, Daptomycin adverse effects, Vancomycin administration & dosage, Vancomycin pharmacology, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents adverse effects, Cephalosporins pharmacology, Cephalosporins administration & dosage
- Abstract
Background: We report the final results of the clinical usage of ceftobiprole in patients in Canada from data in the national CLEAR (Canadian Le adership on Antimicrobial Real-Life Usage) registry., Research Design and Methods: The authors review the final data using the national ethics approved CLEAR study. Thereafter, the literature is surveyed regarding the usage of ceftobiprole to treat patients with infectious diseases via PubMed (up to March 2024)., Results: In Canada, ceftobiprole is primarily used as directed therapy to treat a variety of severe infections caused by MRSA. It is primarily used in patients failing previous antimicrobials, is frequently added to daptomycin and/or vancomycin with high microbiological and clinical cure rates, along with an excellent safety profile. Several reports attest to the microbiological/clinical efficacy and safety of ceftobiprole. Ceftobiprole is also reported to be used empirically in select patients with community-acquired bacterial pneumonia (CABP), as well as hospital-acquired bacterial pneumonia (HABP)., Conclusions: In Canada, ceftobiprole is used mostly as directed therapy to treat a variety of severe infections caused by MRSA, in patients failing previous antimicrobials. It is frequently added to, and thus used in combination with daptomycin and/or vancomycin with high microbiological/clinical cure rates, and an excellent safety profile.
- Published
- 2024
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