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2. Diverse methodological approaches to a Circumpolar multi-site case study which upholds and responds to local and Indigenous community research processes in the Arctic.
- Author
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Healey Akearok GK, Chaliak AJ, Cueva K, Cook D, Larsen CV, Jóhannsdóttir L, Nilsson LM, San Sebastián M, Peterson M, Timlin U, Broderstadt AR, Dagsvold I, Siri S, Olesen I, Stoor JPA, Rautio A, Rink E, and Lavoie JG
- Subjects
- Humans, Arctic Regions, Alaska epidemiology, Canada, Greenland, Pandemics, COVID-19
- Abstract
This paper outlines the methodological approaches to a multi-site Circumpolar case study exploring the impacts of COVID-19 on Indigenous and remote communities in 7 of 8 Arctic countries. Researchers involved with the project implemented a three-phase multi-site case study to assess the positive and negative societal outcomes associated with the COVID-19 pandemic in Arctic communities from 2020 to 2023. The goal of the multi-site case study was to identify community-driven models and evidence-based promising practices and recommendations that can help inform cohesive and coordinated public health responses and protocols related to future public health emergencies in the Arctic. Research sites included a minimum of 1 one community each from Canada (Nunavut,) United States of America (Alaska), Greenland, Iceland, Norway, Sweden, Finland. The approaches used for our multi-site case study provide a comprehensive, evidence-based account of the complex health challenges facing Arctic communities, offering insights into the effectiveness of interventions, while also privileging Indigenous local knowledge and voices. The mixed method multi-site case study approach enriched the understanding of unique regional health disparities and strengths during the pandemic. These methodological approaches serve as a valuable resource for policymakers, researchers, and healthcare professionals, informing future strategies and interventions.
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- 2024
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3. "The needle is already ready to go": communities' and health care professionals' perceptions of routine vaccination in Nunavik, Canada.
- Author
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Dubé, Eve, Renaud, Marie-Pierre, Lyonnais, Marie-Claude, Pelletier, Catherine, and Fletcher, Christopher
- Subjects
MEDICAL personnel ,CANADIAN Inuit ,HEALTH attitudes ,VACCINATION ,VACCINATION coverage - Abstract
Inuit living in the northern region of Nunavik continue to experience significant health inequalities, which are rooted in colonialism that still have repercussions on their health-related perceptions and practices, including vaccination. This study aimed to explore the perceptions and determinants of routine vaccination among the Inuit of Nunavik by describing factors influencing vaccination decisions from the perspective of community members and health professionals. Semi-structured interviews focusing on the perception of vaccination and experience with vaccination and health services were conducted with 18 Inuit and 11 non-Inuit health professionals. Using the socio-ecological model, factors acting at the community and public policy (e.g. rumours and misinformation about vaccination, language barrier), organisational (e.g. complexity of the vaccination process, staff turnover, lack of specialised vaccination workers and interpreters), and intrapersonal and interpersonal (e.g. past experiences with vaccination, vaccine attitudes, social norms) levels were identified as having an impact on vaccination decisions. Improving vaccination coverage in Nunavik requires a more global reflection on how to improve and culturally adapt the health care and services offered to the Inuit population. [ABSTRACT FROM AUTHOR]
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- 2024
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4. A comparative study of governmental financial support and resilience of self-employed people in Sweden and Canada during the COVID-19 pandemic.
- Author
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Hansson, Josefine, MacEachen, Ellen, Landstad, Bodil J., Vinberg, Stig, and Tjulin, Åsa
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COVID-19 pandemic ,FREELANCERS ,FINANCIAL stress ,COVID-19 ,COMPARATIVE studies ,CORPORATION reports - Abstract
Globally, self-employed people were among the hardest hit by the repercussions of the COVID-19 pandemic and faced hardships such as financial decline, restrictions, and business closures. A plethora of financial support measures were rolled out worldwide to support them, but there is a lack of research looking at the effect of the policy measures on self-employed people. To understand how different governmental financial support measures enhanced the resilience of the self-employed and improved their ability to manage the pandemic, we conducted a mixed-method study using policy analysis and semi-structured interviews. The documents described policies addressing governmental financial support in Sweden and Canada during the pandemic, and the interviews were conducted with Swedish and Canadian self-employed people to explore how they experienced the support measures in relation to their resilience. The key results were that self-employed people in both countries who were unable to telework were less resilient during the pandemic due to financial problems, restrictions, and lockdowns. The interviews revealed that many self-employed people in hard-hit industries were dissatisfied with the support measures and found them to be unfairly distributed. In addition, the self-employed people experiencing difficulties running their businesses reported reduced well-being, negatively affecting their business survival. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Mediating effect of craving on the impact of buprenorphine/naloxone and methadone treatment on opioid use: Results from a randomized controlled trial.
- Author
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McAnulty C, Bastien G, Ledjiar O, Eugenia Socias M, Le Foll B, Lim R, and Jutras-Aswad D
- Subjects
- Female, Humans, Analgesics, Opioid therapeutic use, Craving, Opiate Substitution Treatment methods, Canada epidemiology, Buprenorphine, Naloxone Drug Combination therapeutic use, Methadone therapeutic use, Narcotic Antagonists therapeutic use, Opioid-Related Disorders psychology, Buprenorphine therapeutic use
- Abstract
Background: The relationship between opioid craving and opioid use is unclear. We sought to determine to what extent craving mediated the relationship between opioid agonist therapy and changes in opioid use., Methods: Data came from a pragmatic, 24-week, pan-Canadian, multi-centric, open-label, randomized controlled trial comparing flexible buprenorphine/naloxone take-home doses to standard supervised methadone models of care for the treatment of prescription-type opioid use disorder. Participants were randomly allocated to buprenorphine/naloxone or methadone models of care. 270 people with prescription-type opioid use disorder were included in analyses. There were 93 women (34.4%) and 2 transgender (0.7%) participants. Most participants were white (67.4%), 45.9% reported unstable living conditions, and 44.8% had psychiatric comorbidities. Generalized linear mixed models followed by mediation analysis estimated the direct effect of treatment group on Timeline Followback-reported next-week opioid use and the indirect effect through past 24-hour opioid craving measured using the Brief Substance Craving Scale at week 2, 6, 10, 14, 18 and 22., Results: Upon mediation analysis, the average direct effect of treatment on opioid use was 0.465 (95 % CI = 0.183 to 0.751, p < 0.001). The average causal mediated effect was 0.144 (95 % CI = 0.021 to 0.110; p < 0.001). Craving accounted for 23.6 % of the effect of treatment on opioid use (p < 0.001)., Conclusions: Past 24-hour craving was associated with increased next-week opioid use; however, craving only partially mediated the effect of buprenorphine/naloxone and methadone on next-week opioid use. Research is needed to develop a comprehensive understanding of factors mediating opioid use during opioid agonist therapy., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
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- 2024
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6. Cannabis advertising impacts on youth cannabis use intentions following recreational legalization in Canada: An Ecological Momentary Assessment (EMA) study.
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Noël C, Scharf D, Koné A, Armiento C, and Dylan D
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- Adult, Humans, Adolescent, Intention, Ecological Momentary Assessment, Canada, Ontario, Advertising, Cannabis
- Abstract
Objective: In 2018, Canada's Cannabis Act legalized adult recreational cannabis use and limited cannabis product advertising to adults. Cannabis product advertising to youth remains illegal. The extent to which adult-targeted, or illicit youth-targeted cannabis advertisements is reaching and impacting Canadian youth is unknown. We used Ecological Momentary Assessment (EMA) to describe how often and how much exposures to cannabis advertising influence Canadian youths' real-world, real-time intentions to use cannabis., Methods: 120 Ontario, Canada youths ages 14-18, took photos of cannabis advertising that they encountered in their natural environments over a period of nine consecutive days. Following each exposure and twice daily device-issued random prompts, they also rated their intentions to use cannabis., Results: Many participating youth (n = 85; 70.83 %) reported at least one cannabis advertising exposure during the study (range 1-30, M = 4.02). Exposures occurred through a range of advertising channels (e.g., internet ads, billboards). Multilevel modeling showed that youth advertising exposure increased cannabis use intentions in vivo (β = 0.06,SE = 0.03;t = 1.98;p =.04;n = 1,348)., Conclusion: Data from this study shows that cannabis advertisements are regularly reaching Canadian youth and increasing their intentions to use cannabis. This suggests that current Canadian prohibitions on cannabis advertising to youth are ineffective and/or ineffectively enforced, and that the Canadian government needs additional or enhanced prohibitions on cannabis promotion to protect youth from harms associated with increased advertisement exposure, such as increased cannabis use., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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7. A novel MCPFVP-based CFAR detector fusing sea clutter amplitude spatial correlation information.
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Mao, Huihuang, Xie, WenChong, Liu, Weijian, and Meng, Hao
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- *
DISTRIBUTION (Probability theory) , *DETECTORS , *FALSE alarms , *STATISTICS , *RADAR , *AMPLITUDE estimation - Abstract
The performance of constant false alarm rate (CFAR) detectors is often severely degraded in clutter edge and under multiple target interference. CFAR detection in the above environments often uses generalised likelihood ratio method or mean ratio method to find out the clutter edge demarcation line and suppress the sharp increase of false alarm rate, or remove the interference and modify the threshold factor to suppress the interference and improve the detection performance, but this sacrifices the detection gain from the number of clutter samples. In this paper, the feature information is fused to construct feature vectors, and the edge location is judged by the modulus of the cross product of the feature vector pair (MCPFVP), this edge demarcation line detection method fusing with features can be implemented without the need of clutter statistical distribution information. In addition, this paper reconstructs the sea clutter masked by multiple target interference by fusing the sea clutter amplitude correlation information, and these reconstructed sea clutter samples are used for power estimation together with the unmasked sea clutter without changing the threshold factor. This method can not only suppress the target masking effect of multiple target interference as the censoring type CFAR detector, but also maintain the detection gain from the number of clutter samples, which is not possible with the traditional censoring type CFAR detector. In addition, the relative weighted ratio summation (RWRS) is proposed to detect the multiple target interference, which takes into account the asymmetry of the shape of the statistical distribution. Both simulated and real sea clutter data are used to validate the above methods. The measured data are obtained from radar data collected at Yantai Yangma Island, China, Darmouth, Canada and Grimsby, Canada. (The latter two datasets are collected by the IPIX radar - Ice Multiparameter Imaging X-Band Radar). [ABSTRACT FROM AUTHOR]
- Published
- 2024
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8. An investigation on the operational resilience of the Canadian electronic product stewardship program and the recycling business characteristics.
- Author
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Hasan MM, Mahmud TS, Assuah A, Ng KTW, Tasnim A, and Abha AT
- Subjects
- Canada, Recycling methods, Electronic Waste, Waste Management methods
- Abstract
Electronic waste recycling companies have proliferated in many countries due to valuable materials present in end-of-life electronic and electrical equipment. This article examined the business characteristics and management performance of Electronic Products Recycling Association (EPRA), a Canadian nationwide electronic product stewardship organization. The organization's annual performance reports, from 2012 to 2020, for nine Canadian provinces in which it currently operates were aggregated and analyzed. Temporal analysis using regression and Mann-Kendall tests were employed, and five characteristics of EPRA's business were analyzed, including e-waste products collected, number of drop-off locations, efforts to build public awareness, operating expenses, and growth of e-waste stewardship. Results show a decline in the amount of e-waste collected across the provinces, except in New Brunswick, which started its program in 2017. The Mann-Kendall test revealed declining temporal trends in most provinces. Although the collection/drop off sites and stewardship organizations increased astronomically over the study period in Canada, the amounts of e-waste collected decreased. We found that public awareness generally did not increase the amount of e-waste collected, and these campaigns only appeared to be effective in jurisdictions with good accessibility of e-waste recycling. Processing cost accounted for the majority of the e-waste management budget in Canada, and different factors affected the financial success of the stewards differently., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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9. Assessing the 2023 Canadian wildfire smoke impact in Northeastern US: Air quality, exposure and environmental justice.
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Yu M, Zhang S, Ning H, Li Z, and Zhang K
- Subjects
- Humans, Environmental Justice, Canada, Particulate Matter analysis, Environmental Exposure, Wildfires, Air Pollutants analysis, Air Pollution analysis
- Abstract
The Canadian wildfires in June 2023 significantly impacted the northeastern United States, particularly in terms of worsened air pollution and environmental justice concerns. While advancements have been made in low-cost sensor deployments and satellite observations of atmospheric composition, integrating dynamic human mobility with wildfire PM
2.5 exposure to fully understand the environmental justice implications remains underinvestigated. This study aims to enhance the accuracy of estimating ground-level fine particulate matter (PM2.5 ) concentrations by fusing chemical transport model outputs with empirical observations, estimating exposures using human mobility data, and evaluating the impact of environmental justice. Employing a novel data fusion technique, the study combines the Weather Research and Forecasting model with Chemistry (WRF-Chem) outputs and surface PM2.5 measurements, providing a more accurate estimation of PM2.5 distribution. The study addresses the gap in traditional exposure assessments by incorporating human mobility data and further investigates the spatial correlation of PM2.5 levels with various environmental and demographic factors from the US Environmental Protection Agency (EPA) Environmental Justice Screening and Mapping Tool (EJScreen). Results reveal that despite reduced mobility during high PM2.5 levels from wildfire smoke, exposure for both residents and individuals on the move remains high. Regions already burdened with high environmental pollution levels face amplified PM2.5 effects from wildfire smoke. Furthermore, we observed mixed correlations between PM2.5 concentrations and various demographic and socioeconomic factors, indicating complex exposure patterns across communities. Urban areas, in particular, experience persistent high exposure, while significant correlations in rural areas with EJScreen factors highlight the unique vulnerabilities of these populations to smoke exposure. These results advocate for a comprehensive approach to environmental health that leverages advanced models, integrates human mobility data, and addresses socio-demographic disparities, contributing to the development of equitable strategies against the growing threat of wildfires., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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10. High accuracy prediction of the post-combustion carbon capture process parameters using the Decision Forest approach.
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Wang, Xin, Chan, Christine W., and Li, Tianci
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- *
DATA scrubbing , *PLANT performance , *CLEAN energy , *CARBON dioxide , *CARBON , *MACHINE learning - Abstract
This paper investigates the relationships among the important process parameters that impact Post-combustion Carbon Capture (PCC) carbon dioxide (C O 2) separation. A better understanding of the complex relationships among those parameters can support optimization and performance enhancement of the separation process. Being able to precisely predict the process parameters will enable the operator to determine the current state of the process, forecast any potential changes or events, and adjust process parameters to enhance the plant's performance. With the objective of studying the process parameters' correlations in the amine-based PCC process, we modeled the multi-year historical production data of the Clean Energy Technologies Research Institute (CETRi) (formerly known as the International Test Center for PCC or ITC) in Regina, Saskatchewan, Canada, using a Decision Forest approach. The model validation process revealed that the Decision Forest model produced higher predictive accuracy than previous efforts. The Decision Forest models we developed also represent knowledge about the importance of parameters involved in the capture process, and such knowledge is useful for further optimization of the capture process in the future. • Modeling the parameters of the Carbon Capture process with machine learning (ML). • The ML models used Decision Forest with Gradient Boosting and Oblique Split. • The ML models achieved superior predictive accuracy compared to past efforts. • The ML models support interpretability by visualizing weights and prediction paths. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Collaborations in innovation activities of rural SMEs: a configurational analysis.
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Aka, Kadia Georges and Enagogo, Crispin Agadusameso
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SMALL business ,FUZZY sets ,RURAL geography ,ECONOMIC development ,CONSUMERS - Abstract
Copyright of Journal of Small Business & Entrepreneurship is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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12. Multiplicity of alliance learning in the entrepreneurial process: strategies of early-stage biotech firms.
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Wu, Yuanyuan and Perez-Aleman, Paola
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LEARNING ,SMALL business ,MULTIPLICITY (Mathematics) ,BUSINESSPEOPLE ,LEARNING strategies - Abstract
Copyright of Journal of Small Business & Entrepreneurship is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
- Full Text
- View/download PDF
13. Evaluating deep learning methods applied to Landsat time series subsequences to detect and classify boreal forest disturbances events: The challenge of partial and progressive disturbances.
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Perbet, Pauline, Guindon, Luc, Côté, Jean-François, and Béland, Martin
- Subjects
- *
DEEP learning , *LANDSAT satellites , *TAIGAS , *TIME series analysis , *SPRUCE budworm , *TRANSFORMER models - Abstract
The monitoring of forest ecosystems is significantly affected by the lack of consistent historical data of low-severity (forest partially disturbed) or gradual disturbance (e.g. eastern spruce budworm epidemic). The goal of this paper is to explore the use of a subset of Landsat time series and deep learning models to identify both the type and the year of disturbances, including low-severity and gradual disturbances, in the boreal forest of eastern Canada at the pixel level. Remote sensing data such as the spectral information from Landsat time series are the best available option for large scale observations of disturbances that go back decades. Traditional modeling approaches, like LandTrendr, require substantial handcrafted pre-processing to remove noise and to extract temporal features from the image sequences before using them as input to a classical machine-learning model. Deep-learning models can autonomously discern which features are relevant within the coarse temporal and spectral information from the Landsat annual dense time series. We evaluated the performance of TempCNN and Transformer model in detecting and classifying the type and the year of the forest disturbance using Landsat time series subsequences. Our findings resulted in the generation of four disturbance maps outlining the forest history from 1986 to 2021 within the eastern Canadian boreal forest. Our experimental outcomes demonstrate several significant benefits of employing deep learning models. Firstly, using noisy Landsat time series they achieve comparable accuracy for classifying fire and total harvesting than existing publicly available disturbance maps. Secondly, the use of shorter time series subsequence with deep learning models enables to map adequately different overlapping disturbances occurring in the complete time series. Finally, they increase the number of distinguishable disturbance classes by adding partial harvesting, gradual disturbances, and forest recovery from older events, making them useful approaches for obtaining the first remote sensing-based map for areas affected by the eastern spruce budworm. • TempCNN, Transformer tested on Landsat time series for disturbance classification. • The type and the year of disturbance events were classified with good accuracy. • Deep learning effective for identifying partial and progressive disturbances. • Landsat subsequences extract overlapping disturbances. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Contamination of aquatic ecosystems by persistent organic pollutants (POPs) originating from landfills in Canada and the United States: A rapid scoping review.
- Author
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Ochs C, Garrison K, Saxena P, Romme K, and Sarkar A
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- Humans, United States, Ecosystem, Persistent Organic Pollutants, Canada, Waste Disposal Facilities, Solid Waste, Water Pollutants, Chemical analysis, Refuse Disposal
- Abstract
Persistent organic pollutants (POPs) are organic chemical substances that threaten human health and the planet's ecosystems due to their toxicity and their ability to remain intact for a long time, wide distribution throughout the environment, and accumulation and magnification in living organisms through the food chain. Discarded products from landfills and dumpsites are potential sources of POPs due to their persistence for several decades and constant release to surrounding environment. POPs in aquatic systems signal input predominantly from landfills, wastewater treatment plants, sewage, and urban runoff, suggesting a research gap to guide policies to address these unabated releases. This scoping review aims to rapidly identify the key concepts underpinning the containment, translation, and migration of POPs in Canadian and US landfill leachate. The review targeted multidisciplinary perspectives on the topic and spanned forensic biology, environmental sciences, chemistry, and geology. Contaminated municipal solid waste (MSW) landfill characteristics, as reported by government agencies in Canada and the US, were synthesized and harmonized to illustrate the geographical scope of MSW landfills releasing POPs into the surrounding environment. The knowledge and data gaps summarized in this study highlight the need to address the inadvertent release of POPs from Canadian and US landfills, particularly in consideration of dated and degrading landfill infrastructure, the proximity of marginalized people, and the implications of climate change on the countries' more vulnerable landscapes. This review is applicable to the development of future studies that aim to guide environmental protective policies., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
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15. Human biomonitoring of dioxins, furans, and non-ortho dioxin-like polychlorinated biphenyls (PCBs) in blood plasma from Old Crow, Yukon, Canada (2019).
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Simpson AK, Drysdale M, Gamberg M, Froese K, Brammer J, Dumas P, Ratelle M, Skinner K, and Laird BD
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- Animals, Humans, Yukon Territory, Furans toxicity, Biological Monitoring, Canada, Plasma chemistry, Dioxins analysis, Polychlorinated Biphenyls analysis, Crows, Polychlorinated Dibenzodioxins
- Abstract
Dioxins, furans, and dioxin-like polychlorinated biphenyls (PCBs) are a group of persistent and toxic chemicals that are known to have human health effects at low levels. These chemicals have been produced for commercial use (PCBs) or unintentionally as by-products of industry or natural processes (PCBs, dioxins, and furans). Additionally, dioxin-like PCBs were formerly used in electrical applications before being banned internationally (2004). These chemicals are widely dispersed in the environment as they can contaminate air and travel hundreds to thousands of kilometers before depositing on land or water, thereafter, potentially entering food chains. Community concerns surrounding the safety of traditional foods prompted a human biomonitoring project in Old Crow, Yukon Territory (YT), Canada (2019). Through collaborative community engagement, dioxins and like compounds were identified as a priority for exposure assessment from biobanked samples. In 2022, biobanked plasma samples (n = 54) collected in Old Crow were used to measure exposures to seven dioxins, ten furans, and four dioxin-like PCBs. 1,2,3,6,7,8-HxCDD, 1,2,3,7,8,9-HxCDD, 1,2,3,4,6,7,8-HpCDD, OCDD, 2,3,4,7,8-PeCDF, 1,2,3,6,7,8-HxCDF, PCB 126, and PCB 169 were detected in at least 50 % of samples. Among these analytes, the only congener at elevated levels was PCB 169, which was approximately ∼2-fold higher than the general population of Canada. No significant sex-based or body mass index (BMI) differences in biomarker concentrations were observed. Generally, the concentrations of the detected congeners increased with age, except for 1,2,3,4,6,7,8-HpCDD. For the first time, this research measures dioxin and like-compound exposures in Old Crow, advancing the information available on chemical exposures in the Arctic. Further research could be directed towards the investigation of PCB 169 exposure sources and temporal monitoring of exposures and determinants., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
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16. Identifying transcriptomic indicators of tertiary treated municipal effluent in longnose dace (Rhinichthys cataractae) caged under semi-controlled conditions in experimental raceways.
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Marjan P, Martyniuk CJ, Arlos MJ, Servos MR, Ruecker NJ, and Munkittrick KR
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- Female, Male, Animals, Canada, Transcriptome, Gene Expression Profiling, Water, Cyprinidae physiology, Water Pollutants, Chemical analysis
- Abstract
To evaluate effects of tertiary treated wastewater treatment plant effluent (MWWE) on transcriptomic responses in longnose dace (Rhinichthys cataractae; LND) we conducted a semi-controlled study in experimental raceways (Advancing Canadian Water Assets facility) imbedded in the Pine Creek treatment plant (Calgary, AB). LND collected from a reference site in the Bow River (REF) were caged in raceways containing either 5 % Pine Creek effluent (PC) or Bow River water (BR; control) over 28 d. Liver transcriptomes were analyzed in males and females sampled on days 7, 14 and 28 from BR and PC, and compared to REF fish on day 0. Concurrent with the caging, selected environmental substances of concern were analyzed in the BR and PC. Significantly different unigenes (SDUs) in females (vs males) within both BR and PC raceways increased over time and compared to REF fish. Moreover, SDUs in females and males within the same treatment (i.e., BR, PC) showed a temporal increase as well as compared to REF fish. Time was the dominant factor affecting SDUs, whereas sex and treatment had less of an impact on the transcriptome profiling. Gene Set Enrichment Analysis of BR vs PC over time revealed effects on genes involved in growth, metabolism of carbohydrates and lipids, and immune system on day 7; however, by day 28, 80-100 % of the transcripts localized to enriched biomarkers were associated with tissue immune responses in both sexes. Exposure to 5 % effluent had significant effects on female liver somatic index but no effects were observed on other phenotypic health indices in either sex. BR was used as the source of reference water, but analyses showed trace amounts of ESOCs. Analyses did not point towards definitive response patterns that could be used in field-based ecotoxicogenomic studies on the impacts of well-treated MWWE but suggested compromised adaptive immune responses., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
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17. Reactive skin decontamination lotion (RSDL) safety with clinical antiseptics and hemostatic agents.
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Franken J and Mikler J
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- Humans, Animals, Swine, Decontamination methods, Canada, Skin, Anti-Infective Agents, Local toxicity, Hemostatics, Burns
- Abstract
Reactive skin decontamination lotion (RSDL) is a Health Canada approved product used by the Canadian Armed Forces for removal and inactivation of toxic chemicals on skin. Although it is considered very safe when used as directed, questions have been raised regarding whether topical RSDL in the medical setting will react exothermically with antiseptic compounds on the casualty's epidermis that could result in thermal burns. Benchtop experiments were conducted to investigate reactivity of RSDL with various antiseptic compounds or hemostatic agents. Temperature changes were closely monitored in three different volume ratios, 1:10, 1:1, and 10:1 over a time course of 16 minutes. Chlorine based bleaches versus RSDL were included as a positive control and were the only combination that exhibited a significant exothermic reaction capable of causing minor thermal burns. RSDL was also evaluated with antiseptic solution applied to swine epidermal tissue without observation of visual irritation; then in lacerated skeletal muscle tissue which resulted in no measured temperature change. The conclusion of this study is that antiseptics and hemostatic agents can be used as required on a patient decontaminated with RSDL as no exothermic reaction will occur., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper, (Crown Copyright © 2024. Published by Elsevier B.V. All rights reserved.)
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- 2024
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18. Biomonitoring of bisphenol A (BPA) and bisphenol analogues in human milk from South Africa and Canada using a modified QuEChERS extraction method.
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Chi ZH, Liu L, Zheng J, Tian L, Chevrier J, Bornman R, Obida M, Goodyer CG, Hales BF, and Bayen S
- Subjects
- Humans, South Africa, Benzhydryl Compounds analysis, Canada, Biological Monitoring, Milk, Human chemistry, Phenols
- Abstract
A sensitive modified QuEChERS extraction method was developed to assess the levels of free and conjugated bisphenols (BPs) in human milk collected between 2018 and 2019 from two regions of South Africa (the Limpopo Province Vhembe district, n = 194; Pretoria, n = 193) and Canada (Montreal, n = 207). Total BPA (free and conjugated) and BPS were the predominant bisphenols detected in samples from Vhembe and Pretoria, whereas total BPS was the predominant bisphenol detected in Montreal samples. The levels of total BPA in samples from Vhembe and Pretoria ranged between < MDL-18.61 and
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- 2024
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19. "I'm just searching to get better": Constructions of treatment citizenship on injectable opioid agonist treatment.
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Mayer S, Jenkins E, Fairbairn N, Fowler A, and McNeil R
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- Humans, Female, Male, Adult, Middle Aged, Opiate Substitution Treatment methods, Analgesics, Opioid therapeutic use, Analgesics, Opioid administration & dosage, Canada, British Columbia, Qualitative Research, Anthropology, Cultural, Injections, Opioid-Related Disorders drug therapy
- Abstract
Background: As part of the response to Canada's worsening overdose crisis driven by a toxic, adulterated drug supply, there has been increased attention to and expansion of drug treatment, options, including injectable opioid agonist treatment (iOAT). iOAT typically involves the, witnessed daily injection of opioids under healthcare provider supervision. There is a robust, evidence base on iOAT; however, there has been less focus on how people engage with this; treatment outside of clinical trials. This paper examines how people engage with iOAT programs, in expanded treatment settings in Canada, focusing on how the broader socio-structural context, shapes patient subjectivities in treatment., Methods: This study draws on critical ethnographic and community-based research approaches, conducted with people accessing four iOAT programs in Vancouver's Downtown Eastside; neighbourhood from May 2018 to November 2019. Data included in-depth baseline and followup, interviews and approximately 50 h of observation fieldwork conducted in one iOAT, program and with a subsample of participants in the surrounding neighbourhood. Analysis, leveraged the concepts of biological citizenship and structural vulnerability., Results: This analysis characterized three narrative frames-regular long-term engagers, pain, patients, and sporadic and short-term engagers-through in-depth case presentations of participants with distinct types of engagement with iOAT programs. Participants within these, narrative frames described a dominant form of iOAT citizenship, an autonomous patient who, regularly engages in treatment and avoids pleasure. However, structural vulnerabilities, including, homelessness and housing instability, entrenched poverty, criminal-legal system engagement, and unmanaged pain, shaped the ability of participants to make claims to this normative model of citizenship., Conclusion: This study examined how structural vulnerabilities impact people's construction and ability to make iOAT citizenship claims. Findings point to the need for changes within and outside of iOAT programs, such as lower threshold treatment models, improved social services (e.g., secure housing), and pain management support., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
20. Consumer's preferences and willingness to pay for immune enhanced dairy products in Canada.
- Author
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Fasakin I and von Massow M
- Subjects
- Child, Humans, Functional Food, Consumer Behavior, Canada, Dietary Supplements, Dairy Products
- Abstract
This study examined consumer preferences for, willingness to pay for, and the most preferred mode of delivery for immune enhanced dairy products across Canada. Two sets of choice experiments were designed to evaluate preferences for functional foods and nutraceuticals as the modes of delivery for immune enhanced dairy products. Data (N = 1001) was collected through an online stated preference survey and analyzed using conditional logit model. Results revealed that there is a general consumer interest in immune enhanced dairy products, and consumers place a premium on them. Also, the presence of children below the age of fifteen in a household was a major factor that increased consumer receptivity towards the products. Further results revealed that individuals who usually consume functional foods are less likely to be interested in nutraceuticals, and vice versa, implying that the preferred mode of delivery depended on consumer preferences for either functional foods or nutraceuticals., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper, (Copyright © 2023. Published by Elsevier Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
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