1. Voatriafricanines A and B, Trimeric Vobasine-Aspidosperma-Aspidosperma Alkaloids from Voacanga africana .
- Author
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Fouotsa H, Le Pogam P, Mkounga P, Lannang AM, Bernadat G, Vanheuverzwijn J, Zhou Z, Leblanc K, Rharrabti S, Nkengfack AE, Gallard JF, Fontaine V, Meyer F, Poupon E, and Beniddir MA
- Subjects
- Anti-Bacterial Agents isolation & purification, Cameroon, Indole Alkaloids isolation & purification, Molecular Structure, Phytochemicals isolation & purification, Phytochemicals pharmacology, Plant Bark chemistry, Anti-Bacterial Agents pharmacology, Indole Alkaloids pharmacology, Voacanga chemistry
- Abstract
Voatriafricanines A and B ( 1 and 2 ), the first examples of vobasine-aspidosperma-aspidosperma monoterpene trisindole alkaloids, were isolated from the stem barks of Voacanga africana , guided by a molecular networking strategy. Their structures, including absolute configurations, were elucidated by spectroscopic methods and ECD calculations. Compounds 1 and 2 possess intramolecular hydrogen bonding, sufficiently robust to transfer homonuclear and heteronuclear magnetizations. Compound 1 exhibited potent antimycobacterial activity with no discernible cytotoxic activity.
- Published
- 2021
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