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Phytochemical investigation on the dried fruits of Casearia grewiifolia led to the identification of 10 new salicinoyl quinic acid derivatives ( 1 - 10 ), a new benzoyl quinic acid ( 11 ), and two known compounds ( 12 and 13 ). The structures of the new compounds were elucidated by interpreting 1D and 2D NMR spectroscopic data including HMBC and EXSIDE along with a chemical method for sugar unit analysis. All isolates were evaluated for their inhibitory activities against prostaglandin E 2 (PGE 2 ) production in ultraviolet B (UVB)-irradiated HaCat keratinocytes. Of the isolates tested, compounds 6 and 12 were found to inhibit PGE 2 production with IC 50 values of 20.5 and 28.8 μM, respectively.