1. Association of Anthropometric Measures With the Risk of Prostate Cancer in the Multiethnic Cohort.
- Author
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Sattayapiwat O, Wan P, Hernandez BY, Le Marchand L, Wilkens L, and Haiman CA
- Subjects
- Adult, Black or African American statistics & numerical data, Body Height, Body Mass Index, Body Weight, California epidemiology, Hawaii epidemiology, Humans, Male, Middle Aged, Native Hawaiian or Other Pacific Islander statistics & numerical data, Overweight complications, Proportional Hazards Models, Prospective Studies, Prostatic Neoplasms ethnology, Risk Factors, SEER Program, Waist-Hip Ratio adverse effects, White People statistics & numerical data, Young Adult, Prostatic Neoplasms etiology
- Abstract
In studies of anthropometric measures and prostate cancer risk, conducted primarily in White men, positive associations with advanced disease have been reported. We assessed body size in relation to incident prostate cancer risk in 79,950 men from the Multiethnic Cohort, with 8,819 cases identified over 22 years (1993-2015). Height was associated with increased risk of advanced prostate cancer (≥68 inches (≥ 173 cm) vs. < 66 inches (168 cm); hazard ratio (HR) = 1.24, 95% confidence interval (CI): 1.04, 1.48) and high-grade disease (HR = 1.15, 95% CI: 1.02, 1.31). Compared with men of normal weight, men overweight at baseline were at higher risk of high-grade cancer (HR = 1.15, 95% CI: 1.04, 1.26). Greater weight was positively associated with localized and low-grade disease in Blacks and Native Hawaiians (by race, P for heterogeneity = 0.0002 and 0.008, respectively). Weight change since age 21 years was positively associated with high-grade disease (for ≥ 40 pounds (18 kg) vs. 10 pounds (4.5 kg), HR = 1.20, 95% CI: 1.05, 1.37; P for trend = 0.005). Comparing highest versus lowest quartile, waist-to-hip ratio was associated with a 1.78-fold increase (95% CI: 1.28, 2.46) in the risk of advanced prostate cancer. Positive associations with the majority of anthropometric measures were observed in all 5 racial/ethnic groups, suggesting a general impact of anthropometric measures on risk across populations., (© The Author(s) 2021. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2021
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