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Specific causes of preterm birth remain unclear. Several recent studies have suggested that immune changes during pregnancy are associated with the timing of delivery, yet few studies have been performed in low-income country settings where the rates of preterm birth are the highest. We conducted a retrospective nested case-control evaluation within a longitudinal study among HIV-uninfected pregnant Kenyan women. To characterize immune function in these women, we evaluated unstimulated and stimulated peripheral blood mononuclear cells in vitro with the A/California/2009 strain of influenza to understand the influenza-induced immune response. We then evaluated transcript expression profiles using the Affymetrix Human GeneChip Transcriptome Array 2.0. Transcriptional profiles of sufficient quality for analysis were obtained from 54 women; 19 of these women delivered <34 weeks and were defined as preterm cases and 35 controls delivered >37 weeks. The median time to birth from sample collection was 13 weeks. No transcripts were significantly associated with preterm birth in a case-control study of matched term and preterm birth (n = 42 women). In the influenza-stimulated samples, expression of IFNL1 was associated with longer time to delivery—the amount of time between sample collection and delivery (n = 54 women). A qPCR analysis confirmed that influenza-induced IFNL expression was associated with longer time to delivery. These data indicate that during pregnancy, ex vivo influenza stimulation results in altered transcriptional response and is associated with time to delivery in cohort of women residing in an area with high preterm birth prevalence. [ABSTRACT FROM AUTHOR]

At least seven years had passed since subject librarians at Santa Clara University Library performed a comprehensive review of their information resources. A review including journal subscriptions, institutional changes (including a new Cataloging and Metadata Librarian and University Librarian), as well as a new strategic plan, contributed to high noon being declared. Roping together duty and determination, subject librarians, technical services staff, and EBSCO representatives worked together to tame the Wild West landscape and bring order to the new frontier. [ABSTRACT FROM AUTHOR]

Background: Tears of the superior labrum (superior labrum anterior and posterior [SLAP] lesions) of the shoulder are uncommon injuries; however, the incidence of surgical correction seems to be increasing. Purpose: To report the findings of a review of a proprietary descriptive database that catalogs cases for the purpose of board certification on the demographics of SLAP lesion repair. It is the authors’ impression that the percentage of cases of SLAP lesion repairs reported by young orthopaedic surgeons is high and that complications associated with this are not insignificant. Study Design: Cohort study; Level of evidence, 3. Methods: We searched the American Board of Orthopedic Surgery (ABOS) Part II database to evaluate changes in treatment over time and to identify available outcomes and associated complications of arthroscopic repair of SLAP lesions. The database was searched for all SLAP lesions (ICD-9 code 840.7) and SLAP repairs (CPT code 29807) for the years 2003 through 2008. Utilization was analyzed by geographic region and was also obtained based on applicant subspecialty declaration. Results: There were 4975 SLAP repairs, representing 9.4% of all applicants’ shoulder cases. Mean follow-up was 8.9 weeks because of the time-limited case collection period. There were 78.4% who were men, and 21.6% of patients were women. The percentage of shoulder cases that were SLAP repairs increased over the study period from 9.4% to 10.1% by 2008 (P = .0163). Mean age of male patients was 36.4 ± 13.0 years, with a maximum of 85 years. Mean age of female patients was 40.9 ± 14.0 years, with a maximum of 88 years. Pain was reported as absent in only 26.3% of patients at follow-up and function as normal in only 13.1%. There were 40.1% of applicants who self-reported their patients to have an excellent result. The self-reported complication rate was 4.4%. Declared sports medicine specialists had a higher percentage of SLAP repairs than did general orthopaedic surgeons: 12.4% versus 9.2%. Conclusion: The percentage of shoulder cases that are SLAP repairs reported by the candidates is 3 times the published incidence supported by the current literature. The large number of repairs in middle-aged and elderly patients is concerning. Focusing on educating young orthopaedic surgeons to appropriately recognize and treat symptomatic SLAP lesions may bring the rate of SLAP repairs down. [ABSTRACT FROM AUTHOR]

Topography is expected to record tectonic, climatic, and rock strength controls on longterm denudation rates in active margins. We test this hypothesis in the Sierra San Pedro Mártir, Mexico--the footwall of the normal-faulted, western margin of the Gulf of California rift system--by relating topographic metrics with 10Be-derived catchment-averaged denudation rates. Denudation rates and topographic metrics record along-strike gradients in rock uplift relative to base level that increase asymmetrically from fault tips to maxima within the northern half of the range. Surface uplift of an Eocene erosional surface and slope-break knickpoints found at increasingly higher elevations in the northern segments of the Sierra San Pedro Mártir fault system suggest that range asymmetry is due to a recent northward acceleration in the rate of rock uplift relative to base level. By characterizing the relationship between channel steepness and cosmogenic denudation rates, we extrapolate millennial-scale denudation rates to million-year time scales and estimate ages for the transient increase in rock uplift rates and the initial onset of normal faulting. We infer that the Sierra San Pedro Mártir fault system initiated during the middle Miocene (ca. 16-14 Ma) in the center of the range and ca. 12-8 Ma near the fault tips. Recent increases in rock uplift rates during the late Pliocene (ca. 3-2 Ma) coincide with lithospheric rupture in the Delfin basins to the east and represent a westward migration of strain from hanging-wall detachments to the Sierra San Pedro Mártir fault system. Age estimates are consistent with independent geologic constraints and show that pairing of carefully selected cosmogenic denudation rates with topographic analysis can be used to extract tectonic signals from topography over million-year time scales. [ABSTRACT FROM AUTHOR]