6 results on '"S Scott"'
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2. Autoignition behavior of a full boiling-range gasoline: Observations in RCM and GCI engine environments.
- Author
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Rockstroh, Toby, Fridlyand, Aleksandr, Ciatti, Stephen, Cannella, William, and Goldsborough, S. Scott
- Subjects
- *
SHOCK tubes , *WASTE gases , *HEAT release rates , *EXHAUST gas recirculation , *GASOLINE , *HIGH temperatures , *ENGINES - Abstract
The understanding of, and capability to modulate fuel autoignition behavior are important aspects towards the development of advanced, low temperature combustion (LTC) engine concepts, which have potential to significantly increase engine efficiency while at the same time addressing emissions concerns. Proper combustion phasing and control of heat release rates via, for instance, multiple injections and exhaust gas recirculation, are significant challenges that can vary with fuel composition. Overall reactivity, which is a strong function of the in-cylinder temperature and pressure, is a prime driver for regulating combustion timing, while preliminary exothermicity, in the form of low- and intermediate-temperature heat release (LTHR, ITHR) can inhibit, or facilitate operational success, e.g., control combustion phasing. There are still gaps in understanding these features and how they interact with needs of advanced combustion engines, and how practical fuels can be rated for the new challenges of LTC engines. This work utilizes a rapid compression machine (RCM) and gasoline compression ignition (GCI) engine to probe the autoignition behavior of a California Reformulated Gasoline Blendstock for Oxygenate Blending (CARBOB) (RON = 86, MON = 81.4) under quasi- homogeneous charge compression ignition (qHCCI) operation. A wide range of thermodynamic conditions is explored (Tc = 700–1000 K, Pc = 15–90 bar) where ignition delay times and LTHR/ITHR are quantified. Both stoichiometric, dilute (11% O 2) and lean (equivalence ratio (ϕ) = 0.23) fuel loading conditions are considered. The GCI engine is operated under fuel-lean conditions (ϕ = 0.23) using no external exhaust gas recirculation over a range of intake temperature (Tin = 30–70 °C), with the intake pressure adjusted (Pin = 1.2–1.3 bar) to achieve constant combustion phasing (CA50 = −4 °aTDC). Preliminary exothermicity is also quantified under these conditions. The stoichiometric, dilute RCM measurements reveal negative temperature coefficient (NTC) behavior for this fuel and indicate that rates and extents of LTHR and ITHR are both affected by the compressed conditions, with temperature imposing an inverse dependence, while increased pressure causes LTHR to increases, but ITHR to decrease. These are the first experimental quantifications of ITHR trends for a practical fuel under well-controlled, static conditions. When the lean RCM measurements are mapped to the in-cylinder conditions of the engine, it is found that under a constant combustion phasing scenario (as used in the engine), the fuel has little overall temperature sensitivity, while the starts of high temperature heat release (soHTHR) and top dead center (TDC) points seen along the engine compression trajectories correspond to isopleths of ignition delay times τ RCM = 6 and 3 ms, respectively. In addition, the points of peak LTHR rate in the engine correspond to an isopleth of first-stage ignition τ 1,RCM = 0.50–0.75 ms. Correlating the magnitudes of LTHR and ITHR measured in the RCM to the engine requires quantification of the preliminary exothermicity at the thermodynamic conditions of peat LTHR rate and soHTHR, respectively. The current measurements demonstrate how fundamental data from an RCM can be used to project expected trends in overall fuel reactivity to a qHCCI engine environment, and thus provide a possible avenue for characterizing fuels for LTC engines. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
3. The Association of Abdominal Adiposity With Mortality in Patients With Stage I-III Colorectal Cancer.
- Author
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Brown JC, Caan BJ, Prado CM, Cespedes Feliciano EM, Xiao J, Kroenke CH, and Meyerhardt JA
- Subjects
- Adiposity, California epidemiology, Cohort Studies, Female, Humans, Intra-Abdominal Fat diagnostic imaging, Male, Middle Aged, Neoplasm Staging, Prognosis, Registries, Sex Factors, Subcutaneous Fat, Abdominal diagnostic imaging, Tomography, X-Ray Computed, Colorectal Neoplasms mortality, Colorectal Neoplasms pathology, Intra-Abdominal Fat pathology, Subcutaneous Fat, Abdominal pathology
- Abstract
Background: The quantity and distribution of adipose tissue may be prognostic measures of mortality in colorectal cancer patients, and such associations may vary by patient sex., Methods: This cohort included 3262 stage I-III colorectal cancer patients. Visceral and subcutaneous adipose tissues were quantified using computed tomography. The primary endpoint was all-cause mortality. Restricted cubic splines estimated statistical associations with two-sided P values., Results: Visceral adipose tissue was prognostic of mortality in a reverse L-shaped pattern (nonlinear P = .02); risk was flat to a threshold (∼260 cm2) then increased linearly. Subcutaneous adipose tissue was prognostic of mortality in a J-shaped pattern (nonlinear P < .001); risk was higher at extreme (<50 cm2) but lower at intermediate values (>50 to ≤560 cm2). Patient sex modified the prognostic associations between visceral adipose tissue (Pinteraction = .049) and subcutaneous adipose tissue (Pinteraction = .04) with mortality. Among men, visceral adiposity was associated with mortality in a J-shaped pattern (nonlinear P = .003), whereas among women, visceral adiposity was associated with mortality in a linear pattern (linear P = .008). Among men, subcutaneous adiposity was associated with mortality in an L-shaped pattern (nonlinear P = .01), whereas among women, subcutaneous adiposity was associated with mortality in a J-shaped pattern (nonlinear P < .001)., Conclusions: Visceral and subcutaneous adipose tissue were prognostic of mortality in patients with colorectal cancer; the shape of these associations were often nonlinear and varied by patient sex. These results offer insight into the potential biological mechanisms that link obesity with clinical outcomes in patients with cancer, suggesting that the dysregulated deposition of excess adiposity is prognostic of mortality., (© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2020
- Full Text
- View/download PDF
4. Temporal and geographic clustering of polyomavirus-associated olfactory tumors in 10 free-ranging raccoons (Procyon lotor).
- Author
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Giannitti F, Higgins RJ, Pesavento PA, Dela Cruz F, Clifford DL, Piazza M, Parker Struckhoff A, Del Valle L, Bollen AW, Puschner B, Kerr E, Gelberg H, Mete A, McGraw S, and Woods LW
- Subjects
- Animals, California epidemiology, Cluster Analysis, Immunohistochemistry veterinary, Laser Capture Microdissection veterinary, Microscopy, Electron veterinary, Neurilemmoma pathology, Oregon epidemiology, Polymerase Chain Reaction veterinary, Disease Outbreaks veterinary, Neurilemmoma epidemiology, Neurilemmoma veterinary, Neurilemmoma virology, Polyomavirus genetics, Raccoons
- Abstract
Reports of primary nervous system tumors in wild raccoons are extremely rare. Olfactory tumors were diagnosed postmortem in 9 free-ranging raccoons from 4 contiguous counties in California and 1 raccoon from Oregon within a 26-month period between 2010 and 2012. We describe the geographic and temporal features of these 10 cases, including the laboratory diagnostic investigations and the neuropathologic, immunohistochemical, and ultrastructural characteristics of these tumors in the affected animals. All 9 raccoons from California were found within a localized geographic region of the San Francisco Bay Area (within a 44.13-km radius). The tight temporal and geographic clustering and consistent anatomic location in the olfactory system of tumor types not previously described in raccoons (malignant peripheral nerve sheath tumors and undifferentiated sarcomas) strongly suggest either a common cause or a precipitating factor leading to induction or potentiation of neuro-oncogenesis and so prompted an extensive diagnostic investigation to explore possible oncogenic infectious and/or toxic causes. By a consensus polymerase chain reaction strategy, a novel, recently reported polyomavirus called raccoon polyomavirus was identified in all 10 tumors but not in the normal brain tissue from the affected animals, suggesting that the virus might play a role in neuro-oncogenesis. In addition, expression of the viral protein T antigen was detected in all tumors containing the viral sequences. We discuss the potential role of raccoon polyomavirus as an oncogenic virus., (© The Author(s) 2013.)
- Published
- 2014
- Full Text
- View/download PDF
5. Partnership in action: a satellite program to expand an existing bachelor of science in nursing education program.
- Author
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Boyle A, Davis H, Pritchard HK, McBride M, Orsi A, Scott S, and Kresge L
- Subjects
- California, Cooperative Behavior, Education, Professional, Retraining organization & administration, Employment statistics & numerical data, Female, Health Services Needs and Demand, Humans, Licensure, Nursing statistics & numerical data, Male, Marketing of Health Services, Nursing Education Research, Nursing Staff education, Nursing Staff supply & distribution, Personnel Staffing and Scheduling, Program Evaluation, School Admission Criteria, Student Dropouts statistics & numerical data, Students, Nursing statistics & numerical data, Community Health Services organization & administration, Education, Nursing, Baccalaureate organization & administration, Hospitals, Community organization & administration, Interinstitutional Relations, Schools, Nursing organization & administration, Universities organization & administration
- Abstract
The nursing shortage affects communities at many levels, from community hospitals to schools of nursing. The authors describe an innovative 4-way partnership involving a community healthcare district, a community hospital, a community college, and a state university. Working together, these partners established a new baccalaureate nursing program based at a community college and also functioning as a satellite of an existing university-based program, which increased the enrollment of baccalaureate nursing students by 50%. Their work could serve as a model for other collaborative efforts to expand nursing education and reduce the shortage of nurses.
- Published
- 2008
- Full Text
- View/download PDF
6. Father sues doctor over right to be told of alternative therapy for child's brain tumor.
- Author
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Scott S
- Subjects
- California, Child, Female, Humans, Brain Neoplasms therapy, Complementary Therapies legislation & jurisprudence, Malpractice
- Published
- 1999
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