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An oncology nurse talks about her 42-year career at Stanford Medical Center. The technological and pharmacological advances she has seen in that time have changed the face of oncology nursing practice and transformed many previously fatal cancers into curable diseases or chronic illnesses compatible with well-being. The increasing complexity of care requires multidisciplinary collaboration and brings with it new ethical dilemmas. She cautions nurses to make the best use of technology without losing their critical thinking skills, basic assessment skills, and common sense.