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The article profiles optometrist Brian Brown who devoted his career to research and has published 178 papers regarding optometry research. It states that Brian worked for 10 years in Smith-Kettlewell Eye Research Institute in San Francisco, California and has started to investigate age-related macular degeneration (AMD) and was then familiarized himself with multifocal electroretinography (mfERG). It adds that his most important legacy is his contribution in developing future researchers.

Purpose: To assess the ability of the new pattern electroretinogram optimized for glaucoma detection (PERGLA) paradigm to discriminate between healthy individuals and individuals with glaucomatous optic neuropathy (GON). Design: Cross-sectional study. Participants: One hundred forty-two eyes of 71 participants (42 healthy and 29 with GON in at least 1 eye) enrolled in the University of California, San Diego, Diagnostic Innovations in Glaucoma Study were studied. Healthy individuals were those recruited as healthy with healthy-appearing optic disc by examination and masked stereoscopic optic disc photograph evaluation. Glaucomatous optic neuropathy was defined based on stereophotograph evaluation. Methods: The PERGLA (Glaid Elettronica, Pisa, Italy) recordings were obtained within 6 months of standard automated perimetry (SAP) testing. Dependent variables were PERGLA amplitude, phase, amplitude asymmetry, phase asymmetry, and SAP pattern standard deviation (PSD) and mean deviation (MD). Main Outcome Measures: Diagnostic accuracy (sensitivity and specificity) of the PERGLA normative database for classifying healthy and glaucomatous individuals was determined. In addition, performance (areas under receiver operating characteristic curves [AUCs]) of PERGLA amplitude and phase for classifying healthy (n = 84) and GON (n = 50) eyes was determined. Results from both analyses were compared with those from SAP. Results: Sensitivity and specificity of the PERGLA normative database were 0.76 and 0.59, respectively, compared with 0.83 and 0.77 for SAP. The AUCs for PERGLA amplitude and phase were 0.75 and 0.50 (chance performance), respectively. The AUCs for SAP PSD and MD were 0.83 and 0.78, respectively. Conclusions: Pattern electroretinograms recorded using the PERGLA paradigm can discriminate between healthy and glaucoma eyes, although this technique performed no better than SAP at this task. Low specificity of the PERGLA normative database suggests that the distribution of recordings included in the database is not ideal. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references. [Copyright &y& Elsevier]

The article presents a case study of a 79-year-old Pakistanian male admitted to the Jules Stein Eye Institute in Los Angeles, California due to progressive decline of vision in both eyes. It highlights the findings of electroretinogram and fundoscopic examination which revealed a nevative waveform. It emphasizes the diagnosis of the case, cone-rod dystrophy exhibiting Mizou-Nakamura phenomenon.

At the California School for the Deaf, Riverside, 336 deaf students were surveyed for coexistence of retinitis pigmentosa. Five of the 336 were felt to have Usher's syndrome. The most common cause of deafness was maternal rubella. Electroretinograms of the rubella group were normal.