1. The Impact of Administration of Chlorpheniramine/Paracetamol versus Paracetamol Only on the Postoperative Agitation after Orofacial Cleft Repair Procedures in Pediatrics.
- Author
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Ghany Bassiouney, Mohsen Abdel, Talat Taha, Sahar Mohamed, Ibrahim Abdel Rahman, Tamer Nabil, and El Sayed Hafez, Rana Magdy
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CHLORPHENIRAMINE , *PALATE surgery , *ACETAMINOPHEN , *CLEFT lip , *CLEFT palate , *MEDICAL research - Abstract
Background: term "emergence delirium" first appeared in medical literature in early 1960s. While it is frequently used inter-changeably with emergence agitation, it is described as temporary dissociated state of consciousness following anaesthesia discontinuation. Aim and Objectives: aim was to study the role of pre-emptive Chlorpheniramine as an adjuvant to paracetamol in the prevention of emergence agitation in orofacial cleft repair surgeries. Studied cases& techniques: study was prospective, Randomized, Double-Blind Clinical research done at Ain-shams University Hospitals, Cairo, Egypt for 6 months after Medical Ethical Committee approval for children within 3 month up to 18 years with cleft lip or/with cleft palate. Results: On comparison of facial express score between group A & group B, group A showed significant decrease in facial express score compared to group B as the median (IQR) facial express score in group A was 2.0 (2.0- 4.0) and 4.0 (2.0-8.0) in group B. Conclusion: We deduced that preoperative chlorpheniramine 0.2mg/kg and paracetamol 15mg/kg before skin incision is effective medication that can be used to stop or decrease severity of emergence agitation while causing minimal cardio-respiratory depression. It also enhanced quality of healing in post-anesthesia care unit. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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