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Objective: The aim of this study is to examine cost-effectiveness of fluoridation of drinking water supplies for Brisbane and South East Queensland. The benefits conveyed are expressed in reduced costs of dental treatment and years of life with dental caries as a disability. Methods: The analysis utilises a developed life table modelling initial cohort of 36,322 newborns, which when applied to the target population equals to 181,925 persons in the age group 2-100 years, 338,617 persons in the age group 7-100 years and 390,524 persons in the age group 12-100 years respectively. The analysis was conducted using a real discount rate of 3%. Sensitivity analyses investigated the effects of varying the parameters such as: discount rate, costs of dental treatment and costs of fluoridation plant. Uncertainty analysis was also conducted on costs and the measure of ratio of decayed, missing, filled teeth surfaces in deciduous dentition between the cities of Brisbane (non-fluoridated) and Townsville (fluoridated). Results: If fluoridation was implemented there would be a total saving of $10,437.43 (95% CI 6,406.50- 14,035.35) disability-adjusted life years (DALYs) and AU$ 665,686,529 (95% CI -$973,573,625- - $381,322,176). This result is both desirable and dominant as more DALYs are saved along with significant cost savings. Conclusion: Fluoridation remains still a very cost-effective measure for reducing dental decay. [ABSTRACT FROM AUTHOR]

Puberty is a potentially sensitive period during which the adolescent demonstrates rapid changes in aggressive/delinquent behaviour. Early onset of puberty has been implicated, not only in the earlier occurrence of aggressive/delinquent behaviour, but potentially a continuing higher level of aggression/delinquency. This article examines immediate and longer term gender specific changes in aggressive/delinquent behaviour as these are independently associated with the age of onset of puberty and pubertal stage adjusted for age. Data is derived from the Mater–University of Queensland Study of Pregnancy, a prospective prebirth cohort that involves 2,784 respondents who provided information about current pubertal stage (Tanner Score) and the age of onset of puberty, as well as the Achenbach's Youth Self-Report (14-year YSR) and Young Adult Self-Report (21-year YASR). Both males and females had similar increased levels of aggression/delinquency with more advanced pubertal stage at the 14-year follow-up. For females (but not males) early age of onset of puberty was additionally associated with more symptoms of aggression/ delinquency at the 14-year follow-up. For males, by the 21-year follow-up those who had experienced early age of onset of puberty no longer had higher YASR levels of aggression/delinquency. For females, only early and late age of occurrence of puberty were associated with longer term evidence of aggressive/delinquent behaviour. Progression through puberty is associated with increased levels of aggressive/delinquent behaviour for both males and females, and of about a similar magnitude. Female rates of aggressive/delinquent behaviour may have increased over time to match those observed in young males. For females only, there is evidence of a long-term sustained effect of early and late puberty on increased levels of aggressive/delinquent behaviour. [ABSTRACT FROM AUTHOR]

Aims To examine whether there is evidence of an independent association between childhood sexual abuse (CSA) and nicotine disorder in youth and to explore the mechanisms underlying this association in a prospective cohort study. Design Birth cohort study followed-up to 21 years. Setting One of two major obstetric hospitals in Brisbane, Australia. Participants The Mater-University of Queensland Study of Pregnancy involves a prospective birth cohort from a population-based sample involving 7223 singletons whose mothers were enrolled between 1981 and 1984 at the first antenatal visit. The present cohort consisted of a subgroup of 2571 youth who completed the life-time version of the Composite International Diagnostic Interview—computerized version (CIDI-Auto) at the 21-year follow-up. Measurements Nicotine disorder was measured based on Diagnostic and Statistical Manual version IV (DSM-IV) diagnostic criteria and measures of CSA, including retrospective self-reports of rape, were obtained at 21 years. Results Of 2571 young adults, 16.6% met the criteria for either dependence (12.8%) or withdrawal (8.5%). Non-penetrative sexual abuse was reported by 15.5% of respondents and 8.0% reported penetrative sexual abuse. For any types of sexual abuse including non-penetrative, penetrative and self-reported rape before age 16 years, young adults had significantly higher rates of nicotine disorder than young adults who did not experience CSA. This relationship was independent and appeared direct after adjustment for a range of potential confounding and mediating factors. Conclusions This study shows that CSA is associated with young adult nicotine disorder. The results extend the public health significance of findings in this area and highlight the importance of not only intensifying public health efforts to address substance use problems among those who have experienced CSA, but of early intervention, so that emerging risky behaviours may be targeted in the earliest stages. [ABSTRACT FROM AUTHOR]