1. Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau.
- Author
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Huynh MB, Ouidja MO, Chantepie S, Carpentier G, Maïza A, Zhang G, Vilares J, Raisman-Vozari R, and Papy-Garcia D
- Subjects
- Aged, Aged, 80 and over, Brain metabolism, Brain-Derived Neurotrophic Factor metabolism, Brazil, Chondroitin Sulfates metabolism, Extracellular Matrix metabolism, Female, Fibroblast Growth Factor 2 metabolism, Heparin metabolism, Heparitin Sulfate metabolism, Hippocampus metabolism, Humans, Male, Middle Aged, Protein Binding, Temporal Lobe metabolism, Vascular Endothelial Growth Factor A metabolism, Alzheimer Disease metabolism, Glycosaminoglycans metabolism, tau Proteins physiology
- Abstract
Glycosaminoglycans (GAGs), including heparan sulfates and chondroitin sulfates, are major components of the extracellular matrix. Upon interacting with heparin binding growth factors (HBGF), GAGs participate to the maintaintenance of tissue homeostasis and contribute to self-healing. Although several processes regulated by HBGF are altered in Alzheimer's disease, it is unknown whether the brain GAG capacities to bind and regulate the function of HBGF or of other heparin binding proteins, as tau, are modified in this disease. Here, we show that total sulfated GAGs from hippocampus of Alzheimer's disease have altered capacities to bind and potentiate the activities of growth factors including FGF-2, VEGF, and BDNF while their capacity to bind to tau is remarkable increased. Alterations of GAG structures and capacities to interact with and regulate the activity of heparin binding proteins might contribute to impaired tissue homeostasis in the Alzheimer's disease brain., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2019
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