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Purpose: The aim of this study was to identify the factors that are related to the quality of life and sleep of Brazilian speech-language pathology students during the COVID-19 pandemic. Method: This study adopted a cross-sectional, descriptive observational design. A total of 161 undergraduate speech-language pathology students participated in this study. The relationship between quality of life and sleep, socioeconomic characteristics, and health problems was examined using correlational analysis. Participant data were collected using an online form, which included questions that assessed their socioeconomic and health characteristics during the pandemic; the Pittsburgh Sleep Quality Index; and the first two questions of the World Health Organization Quality of Life--Brief Version. Results: There were relationships between sleep dysfunction, a reduction in household income during the pandemic, membership to a risk group, living with at-risk individuals, time spent on the Internet (hours), and the purpose underlying Internet use. Satisfaction with health was related to membership to a risk group. Perceptions of the negative impact of the pandemic on mental health were related to sleep dysfunction and quality of life during the pandemic. Conclusion: The present findings underscore the need for policies that promote health, prevent diseases, and address mental health problems during times of crisis, such as the COVID-19 pandemic.