1. Immunohistochemical characterization of cutaneous leishmaniasis in cats from Central-west Brazil.
- Author
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Headley SA, Pimentel LA, de Amorim IFG, Amude AM, Viana NE, Muraro LS, Tafuri WL, and Dos Santos MD
- Subjects
- Animals, Biopsy, Fine-Needle veterinary, Brazil epidemiology, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell veterinary, Cat Diseases diagnosis, Cat Diseases epidemiology, Cats, Cities, Diagnosis, Differential, Ear, External pathology, Female, Forelimb pathology, Hindlimb pathology, Immunohistochemistry veterinary, Leishmaniasis, Cutaneous diagnosis, Leishmaniasis, Cutaneous epidemiology, Leishmaniasis, Cutaneous parasitology, Nose pathology, Skin Neoplasms diagnosis, Skin Neoplasms veterinary, Cat Diseases parasitology, Leishmania infantum isolation & purification, Leishmaniasis, Cutaneous veterinary
- Abstract
Feline leishmaniasis (FeL) is an emerging infectious disease of cats caused by Leishmania infantum with global distribution. This study investigated the cause of chronic progressive cutaneous lesions in two cats from Central-west Brazil by using cytological, histopathologic, and immunohistochemical (IHC) analyses. Clinically, both cats had ulcerative cutaneous lesions at the nasal planum and ear resulting in a tentative diagnosis of squamous cell carcinoma (SCC). Moreover, both cats had varying degrees of onychogryphosis. However, cytology revealed chronic inflammatory reactions associated with intralesional amastigotes; histopathology confirmed chronic ulcerative dermatitis associated with intralesional and intracytoplasmic parasitic organisms consistent with amastigotes of Leishmania spp. within histiocytes. The IHC assay demonstrated that the intralesional parasitic structures identified by cytology and histopathology were immunoreactive to antigens of Leishmania spp., confirming the participation of this infectious disease agent in the development of the cutaneous lesions of these cats. The observation of onychogryphosis must be highlighted, since this lesion is frequently observed in dogs with visceral leishmaniasis but is underreported in FeL. Collectively, the pathologic and IHC findings of the chronic cutaneous disease confirmed active infections due to Leishmania spp. in these cats. Additionally, FeL with associated lesions to the ear and nasal planum must be considered as differential diagnosis for SCC in cats., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2019
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