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4 results on '"Peixe L"'

2. Silent clonal spread of vancomycin-resistant Enterococcus faecalis ST6 and ST525 colonizing patients at hospital admission in Natal, Brazil.

Author

de Oliveira ES, Freitas AR, Peixe L, Novais C, and Melo MC

Subjects
Bacterial Proteins genetics, Brazil, Carbon-Oxygen Ligases genetics, Gram-Positive Bacterial Infections drug therapy, Humans, Microbial Sensitivity Tests, Sequence Analysis, Anti-Bacterial Agents pharmacology, Enterococcus faecalis drug effects, Enterococcus faecalis genetics, Vancomycin Resistance drug effects, Vancomycin Resistance genetics
Published
2020
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3. Virulence genes, capsular and plasmid types of multidrug-resistant CTX-M(-2, -8, -15) and KPC-2-producing Klebsiella pneumoniae isolates from four major hospitals in Brazil.

Author

Andrade LN, Novais Â, Stegani LMM, Ferreira JC, Rodrigues C, Darini ALC, and Peixe L

Subjects
Brazil epidemiology, Epidemiological Monitoring, Hospitals, Humans, Molecular Epidemiology, Virulence genetics, Bacterial Proteins genetics, Drug Resistance, Multiple, Bacterial genetics, Klebsiella Infections epidemiology, Klebsiella Infections microbiology, Klebsiella pneumoniae enzymology, Klebsiella pneumoniae genetics, Klebsiella pneumoniae pathogenicity, Plasmids genetics, beta-Lactamases genetics
Abstract

We performed a single-month snapshot study of the population diversity of multidrug resistant (MDR) Klebsiella pneumoniae isolates producing carbapenemases and/or extended-spectrum β-lactamases from four major hospitals in Brazil. Isolates produced diverse ESBL (CTX-M-2, -8, -15, SHV-2), KPC-2 or both (CTX-M-2 and KPC-2), linked to specific genetic backgrounds and plasmids from a few families (IncR, IncFIIk, IncL/M) that were shared among clonal lineages within and between hospitals. A high clonal diversity was identified, among isolates from the same ST (ST11, ST15, ST101 or ST340). Diverse capsular types (n=13 K-types) were identified, most of which linked to specific ST (ST11 and K27 or K64, ST101 and K17, ST340 and KL151, ST15 and K24 or ST17 and KL112). Isolates shared a common set of virulence genes (ureA, fimH, uge, wabG, mrkD, entB) and occasionally ybtS (42%) and kfuBC (18%). Our data suggest intra- and inter-hospital spread of common genetic structures and international MDR K. pneumoniae clones., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Published
2018
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4. OXA-23-producing Acinetobacter baumannii: a new hotspot of diversity in Rio de Janeiro?

Author

Grosso F, Carvalho KR, Quinteira S, Ramos A, Carvalho-Assef AP, Asensi MD, and Peixe L

Subjects
Acinetobacter baumannii genetics, Acinetobacter baumannii isolation & purification, Bacterial Typing Techniques, Brazil epidemiology, Cluster Analysis, Electrophoresis, Gel, Pulsed-Field, Genotype, Humans, Molecular Epidemiology, Molecular Typing, Nucleic Acid Hybridization, Polymerase Chain Reaction, Sequence Analysis, DNA, Acinetobacter Infections epidemiology, Acinetobacter Infections microbiology, Acinetobacter baumannii classification, Acinetobacter baumannii enzymology, Genetic Variation, beta-Lactamases biosynthesis, beta-Lactamases genetics
Abstract

Objectives: this study focused on the population structure of OXA-23-producing Acinetobacter baumannii clinical isolates from Rio de Janeiro, Brazil., Methods: the analysis included several genomic typing methods, including PFGE, two multilocus sequence typing (MLST) schemes, sequence group (SG) determination and bla(OXA-51-like) sequencing. The genomic context of the bla(OXA-23) gene was also evaluated using I-CeuI hybridizations and PCR assays., Results: congruent clustering was obtained revealing four lineages. In accordance, four new sequence types (STs) (ST131, ST132, ST133 and ST134) were obtained with the MLST-OD scheme (associated with the Oxford Database) and four (ST79, ST15 and two new allelic profiles) with the MLST-IP scheme (developed by the Institute Pasteur). Four SGs (SG1, SG4 and two new profiles) were identified, allowing the association of 70% of the isolates with European clone II. bla(OXA-51-like) sequencing revealed the presence of bla(OXA-66), bla(OXA-69), bla(OXA-95) and bla(OXA-132)., Conclusions: identification of new STs together with new SG profiles are findings suggestive of a local diversity hotspot that is worth exploring.

Published
2011
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