1. Phase Angle but Not Psoas Muscle Predicts Nutritional Risk and Prognosis in Males with Hepatocellular Carcinoma.
- Author
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Pagano, Ana Paula, Sicchieri, Juliana Maria Faccioli, Morgado, Alexandre Souto de Moraes, Meira Filho, Luiz Fernando, Gonzalez, Maria Cristina, Prado, Carla M., Elias Junior, Jorge, Teixeira, Andreza Correa, and Chiarello, Paula Garcia
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SKELETAL muscle physiology , *RISK assessment , *CROSS-sectional method , *PEARSON correlation (Statistics) , *MALNUTRITION , *PREDICTION models , *PSOAS muscles , *BODY mass index , *T-test (Statistics) , *RECEIVER operating characteristic curves , *STATISTICAL significance , *RESEARCH funding , *NUTRITIONAL assessment , *BODY composition , *BODY weight , *MAGNETIC resonance imaging , *HOSPITALS , *BIOELECTRIC impedance , *DESCRIPTIVE statistics , *STATURE , *KAPLAN-Meier estimator , *NUTRITIONAL status , *SPECTRUM analysis , *ANALYSIS of variance , *SURVIVAL analysis (Biometry) , *ANTHROPOMETRY , *DATA analysis software , *HEPATOCELLULAR carcinoma , *GRIP strength , *DISEASE risk factors , *DISEASE complications - Abstract
Despite those with hepatocellular carcinoma (HCC) being at increased risk of malnutrition, there is a notable absence of practical approaches for nutritional assessment in clinical practice. We investigated the usefulness of phase angle (PhA) and Total Psoas Area Index (TPAI) for indicating nutritional risk and HCC prognosis. Weight, height, body mass index (BMI), adductor pollicis muscle thickness (APMT), and handgrip strength (HGS) were assessed. The Nutritional Risk Index (NRI) was calculated. Body composition was assessed using bioimpedance spectroscopy and magnetic resonance imaging. The Child-Turcotte-Pugh (CTP) score and Barcelona-Clinic Liver Cancer (BCLC) classification determined the prognosis. Fifty-one males with HCC were enrolled (CTP C = 11.8%). PhA showed a moderate positive correlation with APMT (r = 0.450; p < 0.001) and HGS (r = 0.418; p = 0.002) and a weak positive correlation with TPAI (r = 0.332; p = 0.021). PhA had a strong positive correlation with NRI (r = 0.614; p < 0.001). Mean PhA values were significantly different according to disease severity (CTP C p = 0.001, and BCLC D p = 0.053). TPAI had no significant correlation with HGS, CTP, or BCLC. PhA was a superior approach for predicting nutritional risk and prognosis in HCC than TPAI. Lower PhA is associated with disease progression, lower muscle mass and function, greater severity of nutritional risk, and increased mortality in HCC. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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