1. First report of chemical composition and cytotoxicity evaluation of Foraminispora rugosa basidiomata from Brazil.
- Author
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Garcia, V. O., Fronza, M., Von Borowski, R., Alves-Silva, G., Zimmer, A. R., Ruaro, T., Gnoatto, S. C. B., Dallegrave, A., and Silveira, R. M. B.
- Subjects
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HIGH performance liquid chromatography , *BIOLOGICAL assay , *OXYLIPINS - Abstract
Background: Foraminispora rugosa is a species reported from Brazil, Venezuela, French Guiana, Costa Rica and Cuba. It is a basidiomycete in the Ganodermataceae family. In this study, both chemical composition and cytotoxicity of the ethanolic extract of F. rugosa were investigated for the first time. Results: Phylogenetic analysis confirmed the identification of the specimens, and the results of cytotoxicity assays showed that at concentrations of 7.8–500.0 µg/mL the ethanolic extract displayed weak cytotoxicity against the tested cell lines. Five oxylipins were identified by ultra high performance liquid chromatography coupled with quadrupole time-of-flight and mass spectrometry (UHPLC-QTOF–MS). Conclusions: This study provides new insights into the current knowledge of bioactive compounds produced by macrofungi, and provides data for future biological assays with relative selectivity and safety. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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