1. Weight Gain from Birth to Adolescence and TyG Index at Age 18 Years: A Cohort Study in Northeast Brazil.
- Author
-
Gonçalves, Fabiana Cristina Lima da Silva Pastich, de Lira, Pedro Israel Cabral, Oliveira, Marcelo de Santana, Vila Nova Filho, Sidrack Lucas, Eickmann, Sophie Helena, and Lima, Marilia de Carvalho
- Subjects
- *
LIFESTYLES , *RESEARCH funding , *BODY mass index , *EXERCISE , *T-test (Statistics) , *SOCIOECONOMIC factors , *QUESTIONNAIRES , *MULTIVARIATE analysis , *HUMAN growth , *CHI-squared test , *DESCRIPTIVE statistics , *BLOOD sugar , *LONGITUDINAL method , *INSULIN resistance , *NUTRITIONAL status , *TRIGLYCERIDES , *BIRTH weight , *ANTHROPOMETRY , *DATA analysis software , *WEIGHT gain , *REGRESSION analysis , *ADOLESCENCE , *CHILDREN - Abstract
Background: Developmental models suggest that the phenotypes may arise from an immediate or mediated adaptive metabolic response of the perinatal growth. Evidence on the cumulative effects of growth and factors associated with risk of insulin resistance in adolescents is lacking. Objective: To investigate the association between birthweight, weight gain during infancy, childhood and adolescence and the triglyceride-glucose index in adolescents. Methods: This is a cohort of 217 children born at term, followed for the first six months, and reassessed at 8 and 18 years of age. The variables of interest were birthweight, postnatal growth defined as rapid postnatal growth when the weight gain from birth to six months of age was greater than 0.67 z-score, and the same criterion was used for high BMI gain from ages 6 months to 8 years, and from 8 to 18 years. Socioeconomic condition, nutritional status, practice of physical exercises and consumption of ultra-processed foods were verified. Multivariate linear regression analysis was used to verify the effect of the variables on the triglyceride-glucose index. Results: Birthweight was not associated with triglyceride-glucose index in adolescence. Rapid postnatal growth during the first 6 months, higher BMI gain from 8 to 18 years and higher waist circumference contributed significantly to explain higher triglyceride-glucose index. Conclusion for Practice: Our findings suggest that rapid postnatal growth may be one of the first signs of a higher triglyceride-glucose index in adolescence and that attention should be paid to the greater gain in body mass between childhood and adolescence for the risk of a higher triglyceride-glucose index. Significance: What is Already Known on this Subject?: Metabolic disorders are associated with excess weight and body fat in adolescence, however, growth deviations in phases of rapid human development, for example, perinatal period, childhood and adolescence, may be the first signs of future metabolic changes. Less is known about the relationship between growth gains during infancy, childhood and adolescence and the risk of insulin resistance. What this Study Adds?: From longitudinal data, it was observed that higher TyG index levels were observed in adolescents who showed rapid weight gain in the first six months after birth and greater body mass gain between childhood and adolescence. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF