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Affect dynamics in digital learning systems (DLS) research investigates how students' emotions evolve while using these systems. This information can reveal the most common emotions experienced by students and how they transition between them. Recent studies indicate that affect dynamics in DLS vary depending on students' demographic and personal characteristics, such as nationality. However, most research has focused on students from the United States and the Philippines, leaving a gap in understanding Latin American learners and the potential differences in affect dynamics based on gender and emotion duration. This study introduces an affect dynamics model for Brazilian students using a Math DLS in a school setting, encompassing emotions like confusion, frustration, boredom, and engagement. We also present evidence that affect dynamics models differ based on students' gender and emotion duration. Analyzing affect dynamics across cultures allows for better understanding and generalization of the resulting models while also demonstrating the influence of emotion duration and learners' gender on affect dynamics. This knowledge enables tailoring more adaptive interventions for students' emotions in DLS.

The relationship between digital games and the mobilization of cognitive and metacognitive learning strategies deserves attention and needs research that contributes to the understanding of how these strategies can favor the teaching and learning processes. This study describes how university students over 18 years of age mobilize cognitive and metacognitive learning strategies through digital games. The research methodology used was ex post facto with a quantitative approach. 941 students from 22 States and from the Federal District, enrolled in higher education courses at Brazilian colleges and universities, participated in this research. Data collection occurred through the application of an online questionnaire that integrates the Metacognitive Awareness Inventory (MAI) and the Inventory of Cognitive and Metacognitive Strategies with Digital Games (ICMSDG). The results indicated that university students make regular use of metacognitive knowledge, skills, and strategies. Moreover, cognitive and metacognitive learning strategies seem to be more mobilized by digital game players than by nonplayers, particularly among those who played over a longer period of time (9 years or more) and with higher intensity (playing every day). With the results found and analyzed, we observe that this study is relevant for both university professors and game designers who aim to promote metacognition skills.

Intelligent Tutoring Systems (ITSs) for Math still use traditional data input methods: computers' keyboard and mouse. However, students usually solve math tasks using paper and pen. Therefore, the gap between the manner the students work and the requirements imposed by these typing-based systems expose students to an extraneous cognitive load, impairing their learning. Our study investigates the impact of the data input method on students' learning and fluency in solving equations using step-based math ITSs. More specifically, we have considered the standard typing and handwriting input methods. We hypothesized that the students would be more fluent using their handwriting with online recognition to solve math equations than using the typing input method. This fluency indicates a reduction in cognitive load, freeing working memory for logical reasoning instead of interface preconditions, leading to improved learning. We have conducted an experiment with 55 seventh-grade students from a private school to validate the hypothesis, randomly assigned to control and experimental groups. Each group used one of the input methods on two different devices (desktop computers and tablets). Although students using handwriting solved more equations and were faster than students who typed their equations, we could not find statistically significant differences in the learning between students that used typing or handwriting. Additionally, we have found that the input method used in a not ideal device (e.g., handwriting with a computer's mouse instead of using a touch screen device) can negatively affect the students' performance.

In this paper, we sought to analyze if the internet and social networks usage could be impacting the constitution of an assertive political culture among young people in South Brazil. We hypothesize that although these new socialized agents are widespread among the young, apathy and disinterest in politics remain. To test our hypothesis, we analyzed data from a survey conducted with secondary school students from Porto Alegre in 2015 and 2019 for values related to democracy, feelings about politics, responsiveness, and political efficacy. Results confirm that the political culture of the young remains apathetic, but those socialized by new agents seem to be closer to developing an assertive type of political culture.

Background: Preschool is a crucial period for developing motor skills. Objective: This study evaluated factors associated with motor competence in preschoolers from a Brazilian urban area. Methods: A total of 211 preschoolers (51.2% girls and 48.8% boys) were evaluated. Body mass index was calculated; the Brazilian Economic Research Criterion, the Mini-Mental Scale (MMC) and the Early Childhood Environment Rating Scale®, Revised (ECERS-R™) were applied; the Habitual Physical Activity time was recorded; the Test of Gross Motor Development (TGMD-2) was performed. Univariate analysis was performed using simple linear regression for the independent variables, considering the motor test subscales as dependent variables. Variables with p < 0.20 in the univariate analysis were considered for the multiple linear regression model and were entered into the stepwise method. Results: The independent variables remaining in the Standard Score Locomotor model were BMI, presence of park at school, and MMC (R[superscript 2] = 0.16). The independent variables remaining in the Standard Object Control score were MMC and gender (R[superscript 2] = 0.03). The variables associated with the highest scores of Gross Motor Quotient were MMC, body mass index, and presence of a park at school, respectively (R[superscript 2] = 0.11). Conclusions: Male eutrophic preschoolers who are physically active and attend schools with parks or courtyards in a Brazilian urban area have the highest scores for global cognitive function and motor competence.

This article aims to analyze the experiences of teachers on the uses of ICTs in the development of teaching practices within the framework of a new learning ecology. We use the SAMR model to scale the levels of ICTs contributions in each practice. 116 teachers from a public educational institution in Brazil answered a questionnaire during the pandemic scenario, while conducting emergency remote teaching. Teachers declared to develop the teaching practices with the integration of ICTs at the levels of Augmentation and Modification by correspondence to the SAMR model. Based on the analyzes carried out, we propose some reflections that help to rethink this model and to understand the second-order barriers that prevent the effective integration of ICT in teachers' practices.

Arts offer an engaging opportunity to bring about women's underrepresentation issues in physics. In this work, we report the creation process, production, and reception of the short 360° video entitled 'Women in Science.' This movie maps and portrays female researchers' situation in physics at the University of Sao Paulo, a representative subset of the Brazilian physics community. The 360° movies are a novel way of storytelling, attracting public attention, and increasing the empathy caused by immersive experiences. The plots were based on interviews and surveys that embodied the female researcher's experiences over distinct career phases and levels. Challenges concerning the work environment, peer relationships, and the balance between work and personal life have been covered in the movie. All of them emerged in the descriptive analysis as effects that can influence women's career paths and affect their production capacity. This paper summarizes and discusses the scenes and the creative choices over the whole film production. It also reports the movie exhibition and dissemination processes by online streaming video platforms and public sessions with Virtual Reality (VR) gadgets. Based on the attendees' spontaneous response, it is possible to conclude that the movie brought contributions and promoted discussions on gender-related issues in the academic environment. Art, combined with VR immersive narratives, has proved to be an engaging, low-cost, and reproducible way to communicate sensitive issues to the viewers. Moreover, these experiences through 360° videos can be extended to document and highlight issues from women and other underrepresented minorities in physics.

The use of e-learning services is growing in different contexts, especially in the COVID-19 pandemic. This study aims to examine students' acceptance of and intention to use Learning Management Systems (LMSs) for university education in Brazil using the extended technology acceptance model, unified theory of acceptance and use of technology (UTAUT), integrating quality construct adapted from the Service Quality Evaluation Model (ServQual). Examining a large sample (n = 1237) of students in Brazil through questionnaires, we investigate the behaviour of the users concerning the factors that influence the technology acceptance and the intention of the use in an e-learning system. Results show that intention to use an LMS is affected by the facilitating conditions (skilful, workable and easy to use), social influence (remarkable, preference for use and relevance), habit (routine, enjoyable and entertaining) and quality (reliable, tangibility, responsiveness and assurance), but not for effort expectancy (agility, knowledge and productivity). Our research findings suggest fostering replicate the model in different universities and countries understanding potential differences.

Assessments of intelligence have neglected to examine creativity in most test batteries, thus inhibiting a complete understanding of cognitive functioning. This study aimed to analyze whether creativity could be combined with intelligence in a group test battery (BAICA- Intelligence and Creativity Battery) and to verify whether creativity was related to fluid and crystallized intelligence tasks or if it was an independent factor. The sample was composed of 450 individuals (299 F, 151 M) living in 6 Brazilian states, with ages ranging from 14-50 years old (M = 21.42, SD = 7.70). Seven tasks related to fluid intelligence (Gf; logical thinking, visual spatial ability, visual memory, speed of thinking) and crystallized intelligence (Gc; synonyms, antonyms, verbal analogies), along with 3 tasks related to creative thinking (Cr; fluency, flexibility, originality, and elaboration) were studied through confirmatory factor and network analyses. The results indicated better adjustment indices for Model 3, which was composed of the G factor explained by Gf (including analogies), Gc and Cr. The network analysis confirmed the relationships among these factors and the same pattern for both sexes. In conclusion, there is a need to integrate creativity as a distinct construct for assessing intelligence to obtain a better comprehension of human potential.

There is increasing recognition of the importance of creativity for social development. The purpose of this study was to investigate whether there were differences among Brazilian and Portuguese women recognized for their creative excellence in relation to the psychological and environmental factors that might impact their achievements. The sample was composed of 33 women; 18 who were socially recognized for excellence in creativity in different areas (nine Brazilian, nine Portuguese) were compared to 15 who were not recognized (nine Brazilian, six Portuguese). The instruments used were the Biographical Questionnaire of Creative Women, a semi-structured interview guide, and the Creative Production Analysis Guide. Non-parametric tests indicated significant differences in environmental factors and personal cognitive characteristics between the creative and non-creative women when compared within each country. However, no significant differences among Brazilian and Portuguese creative women were found, thus indicating that they present similar psychological profiles.

Purpose: The authors aimed to triangulate food intake data obtained by two qualitative methods (in-depth interviews and participant observations) and one quantitative method (food-frequency questionnaire (FFQ)). The purpose of this paper was to analyze the kind of data each method produced and how these different pieces of information are methodologically related to the characteristics and limitations of different methods used and theoretically connected to participants' identities and masculinities. Design/methodology/approach: The analysis was based on data from an ethnographic study; whose participants were 35 men who self-identified as gay bears. The participants' food intake was investigated through participant observations, in-depth interviews and an FFQ. Findings: The qualitative methods indicated an overconsumption of meat and beer and a rejection of fresh foods, especially fruits and vegetables, as diacritical signs of the bears' identity. The FFQ showed a major consumption of minimally processed food, with fruits and vegetables being eaten more than meat. The authors proposed that the participants have compartmentalized their many habitual intakes and assessed one of them, separately, according to the method used (what was being asked and the context of that moment). Additionally, the authors connected these two patterns of habitual intake to the participants' identities and masculinities, questioning the existence of a constant hegemonic masculinity among this group. Originality/value: The triangulation of methods employed in the present study is seldom addressed in the literature. This approximation provided a rich discussion regarding the connections between eating, sexuality, gender and identity, through a novel methodological and theoretical lens.

Background: Heart failure may cause peripheral and respiratory muscle alterations, dyspnea, fatigue, and exercise intolerance, worsening the quality of life of patients. Objectives: The aims of this study were to analyze respiratory muscle strength and quality of life of patients with heart failure and correlate them with clinical variables and functional classification. Methods: This cross-sectional study involved patients with heart failure. A manovacuometer assessed maximum inspiratory and expiratory pressures, and quality of life was assessed using the Minnesota Living with Heart Failure Questionnaire. Functional classification was categorized according to the New York Heart Association (NYHA) class in I, II, III, or IV. Results: We included 60 patients (66.7%male) with a mean age of 62.0 years and mean left ventricular ejection fraction of 42.0%. Maximum inspiratory pressure and maximum expiratory pressure were close to normal (>70% of predicted) in most patients; however, a subgroup composedmostly of patients with dilated heart failure and NYHA class III (n = 21) presented lowmaximum inspiratory pressure values (59.2%; 95%confidence interval, 55.7%-62.8%). The mean total score of theMinnesota Livingwith Heart Failure Questionnairewas 44.4 points, being negatively correlated with left ventricular ejection fraction (r = -0.29, P = .02). Patients withNYHAclass III and disease duration longer than 120months presented higher total (P < .01) and physical dimension scores. Conclusions: Most patients had respiratory muscle strength close to normal; however, thosewith dilated heart failure and NYHA class III presented lowmaximum inspiratory pressure values. Quality of life wasmoderately compromised, mainly because of long disease duration, NYHA class III, and low left ventricular ejection fraction. [ABSTRACT FROM AUTHOR]

Institutional change has been identified as inherent to social innovation proposals, especially in developing contexts. However, it is still unclear how these changes occur in the social innovation process. Therefore, our study seeks to answer the following research question: How do attempts at institutional change occur in the social innovation process in an emerging context? We use the qualitative approach to investigate two Brazilian social innovation cases striving to change the institutional environment in which they operate. Our data reveals that institutional change may be necessary before the scalability stage of the social innovation process. We suggest that this finding is related to the developing context, which requires social entrepreneurs and their teams to break institutional barriers to expand their social innovation initiatives. We have also identified some mechanisms used for the attempts to institutional changes: competition with government organisations, influence in formulating laws, and support for the market growth and the entry of new participants. [ABSTRACT FROM AUTHOR]

Objectives: To compare the course of generic and specific health-related quality of life (HRQOL) of individuals with stroke, and its physical, mental, and social domains, at three, six, and 12 months after hospital discharge, considering the levels of stroke severity. Methods: This is a longitudinal study, in stroke individuals, assessed during hospital admission by the National Institutes of Health Stroke Scale (NIHSS), and divided into mild (NIHSS ≤3) or moderate/severe (NIHSS ≥4) disease. At three, six, and 12 months after hospital discharge, the individuals were assessed for generic (Short Form Health Survey–36: total score and physical and mental domains) and specific (Stroke Specific Quality of Life Scale: total score and social domain) HRQOL. A 2 × 2 repeated measures analysis of variance (ANOVA) with post-hoc was applied. Results: 146, 122, and 103 individuals were assessed at three, six and 12 months, respectively HRQOL courses showed different behaviors according to stroke severity (3.37≤F ≤ 4.62; 0.010≤p ≤.036). Individuals with mild stroke showed significant changes in the physical domain, with a reduction between three and six months, and an increase between six and 12. Moderate/severe individuals showed a significant increase in all HRQOL variables between three and six months, and a maintenance of values for almost all variables, except for physical domain, which improved significantly between three and six months, and got significantly worse between six and 12. Conclusions: HRQOL during the first year after stroke showed distinct trajectories, being stroke severity an important factor in identifying stroke subjects at risk of HRQOL decline. Clinical Implications: These results demonstrate the importance of considering not only the phase of the stroke, the severity, and the general and specific HRQOL, but also the physical, social, and mainly the mental domain, which has long been neglected, when assessing this population. [ABSTRACT FROM AUTHOR]

Background: Globally, dietary patterns are shifting toward an increased consumption of ultra-processed foods, raising the risk of some metabolic and nutritional diseases from a young age. This trend is now also affecting low- and middle-income countries. Considering this, we aimed to assess the contribution of ultra-processed foods to total energy intake and their association with the nutritional intake of children and adolescents in Cantagalo, São Tomé and Príncipe. Methods: We conducted a cross-sectional study with a sample of 546 households. Data were collected on anthropometrics, sociodemographic characteristics, and lifestyle, including 24 h food recall questionnaires for children and adolescents. The reported foods were nutritionally assessed and categorized according to the NOVA classification to estimate the contribution of ultra-processed foods. Logistic regression models were used to estimate the magnitude of the associations between higher consumption of ultra-processed foods and nutritional intake, adjusting for confounders. Results: The contribution of ultra-processed foods to daily energy intake was 9.5% for girls and 8.5% for boys. Higher consumption of ultra-processed foods was significantly associated with a lower intake of fiber (OR = 0.932; 95%CI, 0.872–0.996), vitamin B12 (OR = 0.812; 95%CI, 0.668–0.985), and zinc (OR = 0.443; 95%CI, 0.308–0.639) and a higher intake of iron (OR = 1.479; 95%CI, 1.065–2.055) and sodium (OR = 1.001; 95%CI, 1.000–1.001), after adjusting for confounders. Conclusion: Higher consumption of ultra-processed foods was especially associated with a lower intake of fiber, vitamin B12, and zinc, and with a higher intake of iron. [ABSTRACT FROM AUTHOR]

The consumer increasingly associates quality food with safe food. Consequently, major brands publicize their products by emphasizing quality, always associating them with strict control of the production system. The objective of the present work was to evaluate the hygienic-sanitary conditions of refrigerators located in the municipality of Paraipaba (CE). This was a descriptive case study with quantitative approach conducted in three refrigerators in which it was coded as F 01, F 02 and F 03. To obtain the data, a Chec Klist list was used as resolution no. 216 of 2004, to evaluate the buildings, facilities, equipment, furniture and utensils and their hygiene, manipulators, raw materials and packaging, food preparation, storage and exposure to the consumption of prepared food. The results of fridge 01 showed a total percentage of 67.56% of conformities and 32.44% of nonconformities, refrigerator 02 presented 67.56% of conformities and 32.44% of nonconformities, refrigerator 03 presented 70.27% of conformities and 29.73% of nonconformities. In this way, the awareness and training of manipulators with guidance on basic health and hygiene and good practices in food manipulation is necessary [ABSTRACT FROM AUTHOR]

This research adapted the Life Skills Scale for Sport (LSSS) into Portuguese and provided evidence for its construct validity. Study 1 included four translators and five academics who developed a Portuguese version of the LSSS (P-LSSS). During this study, evidence for the content and substantive aspects of construct validity was provided using an expert panel and 25 sports participants. Study 2 included 413 participants that completed the P-LSSS. Within this study, evidence for the structural aspect of construct validity was provided via factor analyses. Study 3 included 134 participants who completed the P-LSSS and a measure of motivation. This study provided evidence for the external aspect of construct validity, with results showing more self-determined motivation had positive relationships with participant's life skills development. Overall, our findings provided evidence for the construct validity of P-LSSS scores. Researchers and practitioners can use the P-LSSS to assess life skills development within sports participants.

Purpose: This study aims to measure the influence of the barriers present in the knowledge transfer at the sales process, by the franchisor to the franchisee, in language schools in the São Paulo/SP city, Brazil. The theoretical aspects include the transfer of knowledge displayed through communication model and barriers inherent in this process. Using (Szulanski 1996) approach the barriers may occur in relation to, namely, the content of knowledge; context; the source; the recipient. Design/methodology/approach: The methodology is quantitative and the type of research is exploratory and descriptive. For this investigation was used an adapted version of the questionnaire developed by Szulanski (1996), applied to a sample of 79 franchised language schools linked to the Brazilian Franchise Association. Beyond factor analysis it was used the nonparametric test of Jonckheere-Terpstra and analysis of variance, to comparing schools. Findings: The results of this analysis revealed that certain types of knowledge transfers are evaluated by the franchisees as more favorably or unfavorably according to the brand franchise. These results show a lack of standardization trend of the activities of the sales process and mismatches with the guidelines of the franchisor. The authors highlight that in the comparison between the brands is evident the dominance of the CNA in relation to other networks of language franchises when analyzed the relationship factors, technical adequacy, absorption of knowledge, competence to absorb knowledge and in the indicators contribution to revenue, acceptance of guidelines and bring results. Originality/value: This research contributes to the identification of barriers that are involved during the transfer of practices of the franchisor to the franchisee on the knowledge of the sales process in language schools, awakening in franchisee reflections of improvements and solutions that can be worked on and developed in their units. Specifically, the study contributes to the knowledge management literature in franchises, as this topic is still emerging, as it presents conflicting findings.

Background: The step test provides valuable information on cardiorespiratory parameters such as maximal oxygen uptake and heart rate. Cardiorespiratory capacity is critical to health-related fitness, with heart rate recovery after exercise serving as a predictor of mortality risk. Main Body: The primary objective of this review was to identify trends, key contributors, and emerging themes in the step test literature through 2023 using the Web of Science Core Collection. Bibliometric data extraction and analysis were performed using a dedicated bibliometric software (VOSviewer). The analysis showed continued interest through 2021. The research categories highlight the multidisciplinary nature of the step test, covering cardiovascular systems, respiratory systems, sports sciences, and medicine. It has gained global attention, with 31 countries involved, with Brazil and the United States leading the way. The diversity of contributing nations is increasing, reflecting a growing global interest. With 111 journals involved, such as Respiratory Care and Medicine and Science in Sports and Exercise, step test research is spread across the academic landscape. With 761 contributing researchers, there is a collaborative and diverse community. The top 10 institutions, including the University of Alabama System and Monash University, illustrate the variety of settings in which step test studies are conducted. Step test studies span multiple disciplines, underscoring their adaptability. The clusters identified in this bibliometric analysis of the step test literature guide future research, suggesting avenues for refining protocols, exploring health implications, optimizing tests for specific conditions such as chronic obstructive pulmonary disease, and adapting step tests in diverse populations. Conclusions: Practical implications highlight the role of the step test in cardiovascular risk assessment, fitness monitoring, and rehabilitation. This broad review underscores the relevance of the step test in diverse settings, reflecting its adaptability and ease of application across occupational and clinical settings. Key Points: Global interest and research in the step test has grown significantly, with contributions from 31 countries and diverse disciplines, highlighting the adaptability and multidisciplinary relevance of the step test. Practical implications of the step test include its critical role in cardiovascular risk assessment, fitness monitoring, and rehabilitation. [ABSTRACT FROM AUTHOR]

Despite the great diversity of Brazilian anuran species, there are still many knowledge gaps about the acoustic communication of these animals. Among the species, those classified as 'Data Deficient' have the greatest gaps in knowledge on their behavior. This is the case of Boana ericae, a species belonging to the Boana pulchella group, endemic to the Chapada dos Veadeiros National Park region, in the northeast of the state of Goiás, Central Brazil. Three distinct call types (A, B, and C) are currently known for B. ericae, with the type A call associated with attracting reproductive partners and the type C call presenting a territorial function. We recorded the vocalizations of 10 individuals of this species and found the presence of vocalizations composing three new note types (D, E, and F). Our results indicate that air temperature and body condition influenced the acoustic parameters of the advertisement and aggressive calls of this species. We also observed that some acoustic parameters of the advertisement calls can be used for individual recognition for showing greater variation among individuals than intra-individually. Our results add new information regarding the vocal repertoire in this species, expanding their known intra-individual classification of the acoustic parameters. [ABSTRACT FROM AUTHOR]

The rapid expansion of Uber Technologies, Inc.'s ride-sharing, courier service, and food delivery system and e-hailing applications has been transforming the logistics network and urban mobility around the world. We aimed to evaluate the impact of the Uber system on traffic injury (TI) mortality during its implementation in Brazilian capital cities. A quasiexperimental design of interrupted time series was used. The monthly mortality rates for TI standardized by age were analyzed. The date of availability of the Uber app, specific to each capital, was considered the start date. Data from the Brazilian Mortality Information System and the Brazilian Institute of Geography and Statistics were used. For the data analysis, from an interrupted time-series design, autoregressive integrated moving average (ARIMA) models with a transfer function were fitted. In 92.6% (n  = 25) of Brazilian capitals, there was no impact of Uber system implementation, 12 months after the start of its activities, on TI mortality. A reduction in mortality from this cause was observed after the system was implemented in Belo Horizonte and Rio de Janeiro. The impact on TI mortality was progressive and continuous in both. More studies are needed to establish the factors associated with the inequalities observed in the impact of Uber system implementation between different locations and the heterogeneity of effects. [ABSTRACT FROM AUTHOR]

Introduction: The PERMA model of well-being has gained prominence in the study of well-being by the Positive Psychology movement. However, the model has been little studied regarding its applicability in different populations, such as adolescents. This study sought to evaluate the psychometric properties of the PERMA-Profiler instrument for Brazilian adolescents, as well as the measurement invariance for different age groups and gender, and investigate the relation with external variables. Methods: Confirmatory Factor Analysis and Multigroup Confirmatory Factor Analysis were used to test the internal structure and invariance of the PERMAProfiler. Reliability was determined with McDonald’s Omega and composite reliability. A total of 1,197 adolescents between 11 and 19 years old from different regions of Brazil participated. Results: The results of the confirmatory factor analysis indicated that the five correlated factors model was the most appropriate, presenting good factor loadings and adequate reliability. The scale proved to be invariant for adolescents of different age groups and gender. Correlations with associated variables were significant and moderate to strong, showing positive relations between positive emotions and well-being, and negative relations with negative affects and depressive and anxiety symptoms. Discussion: These results contribute to the understanding of well-being in adolescence and highlight the importance of promoting different components of well-being for adolescents’ mental health. [ABSTRACT FROM AUTHOR]

We analyzed the effects of load magnitude and bar velocity variables on sensitivity to fatigue. Seventeen resistance-trained men (age=25.7±4.9 years; height=177.0±7.2 cm; body mass=77.7±12.3 kg; back-squat 1RM=145.0±33.9 kg; 1RM/body mass=1.86) participated in the study. Pre- and post-exercise changes in the mean propulsive velocity (MPV) and peak velocity (PV) in the back-squat at different intensities were compared with variations in the countermovement jump (CMJ). CMJ height decreased significantly from pre- to post-exercise (∆%=−7.5 to −10.4; p<0.01; ES=0.37 to 0.60). Bar velocity (MPV and PV) decreased across all loads (∆%=−4.0 to −12.5; p<0.01; ES=0.32 to 0.66). The decrease in performance was similar between the CMJ, MPV (40% and 80% 1RM; p=1.00), and PV (80% 1RM; p=1.00). The magnitude of reduction in CMJ performance was greater than MPV (60% 1RM; p=0.05) and PV (40% and 60% 1RM; p<0.01) at the post-exercise moment. Low systematic bias and acceptable levels of agreement were only found between CMJ and MPV at 40% and 80% 1RM (bias=0.35 to 1.59; ICC=0.51 to 0.71; CV=5.1% to 8.5%). These findings suggest that the back-squat at 40% or 80% 1RM using MPV provides optimal sensitivity to monitor fatigue through changes in bar velocity. [ABSTRACT FROM AUTHOR]

To investigate the validity of six age-predicted maximum heart rate (HRmax) equations after stroke. Sixty individuals (54 (12) years; 64 (69) months after stroke) were included. A Cardiopulmonary Exercise Test (CPET) performed on a treadmill obtained the HRmax. The most used age-predicted equations were investigated: (1) 220-age, proposed by Fox; (2) 206.9– (0.67 × age), proposed by Gellish; (3) 208– (0.7 × age), proposed by Tanaka; (4) 216.6– (0.84 × age), proposed by Astrand; (5) 164– (0.72 × age) and (6) 200– (0.92 × age) proposed by Brawner. No statistically significant agreement was found between the HRmax obtained by the CPET and the one predicted by the equations 1–5 (–0.18 ≤ 95% confidence interval ≤0.79). A significant and moderate agreement was found between the HRmax obtained by the CPET and the one predicted by equation (6) (95% CI= 0.05–0.75; Intraclass Correlation Coefficient= 0.51). Bland-Altman plots showed that equations (1–4) and (6) overestimated the HRmax. Equation (6) presented the lower mean difference. The equations developed for non-disabled individuals (1–4) are not adequate to be used in individuals after a stroke. Equation (6) (Brawner) showed the best results to be used in individuals after stroke; however, it should be used cautiously. Prediction equations for maximum heart rate (HRmax) are commonly used to prescribe aerobic exercise for individuals following a stroke. The equations developed for non-disabled individuals are not valid for use with individuals after stroke, leading to an overestimation of the HRmax. An age-predicted HRmax equation developed for individuals with coronary heart disease may provide outcomes that are more accurate for stroke survivors, but care should still be taken when using it. [ABSTRACT FROM AUTHOR]

Phosphorus (P) is a critical nutrient for plant growth, yet its uptake is often hindered by soil factors like clay minerals and metal oxides such as aluminum (Al), iron (Fe), and calcium (Ca), which bind P and limit its availability. Phosphate-solubilizing bacteria (PSB) have the unique ability to convert insoluble P into a soluble form, thereby fostering plant growth. This study aimed to assess the efficacy of inoculation of Bacillus megaterium B119 (rhizospheric) and B. subtilis B2084 (endophytic) via seed treatment in enhancing maize yield, grain P content, and enzyme activities across two distinct soil types in field conditions. Additionally, we investigated various mechanisms contributing to plant growth promotion, compatibility with commercial inoculants, and the maize root adhesion profile of these strains. During five crop seasons in two experimental areas in Brazil, Sete Lagoas-MG and Santo Antônio de Goiás-GO, single inoculations with either B119 or B2084 were implemented in three seasons, while a co-inoculation with both strains was applied in two seasons. All treatments received P fertilizer according to plot recommendations, except for control. Both the Bacillus strains exhibited plant growth-promoting properties relevant to P dynamics, including phosphate solubilization and mineralization, production of indole-3-acetic acid (IAA)-like molecules, siderophores, exopolysaccharides (EPS), biofilms, and phosphatases, with no antagonism observed with Azospirillum and Bradyrizhobium. Strain B2084 displayed superior maize root adhesion compared to B119. In field trials, single inoculations with either B119 or B2084 resulted in increased maize grain yield, with relative average productivities of 22 and 16% in Sete Lagoas and 6 and 3% in Santo Antônio de Goiás, respectively. Co-inoculation proved more effective, with an average yield increase of 24% in Sete Lagoas and 11% in Santo Antônio de Goiás compared to the non-inoculated control. Across all seasons, accumulated grain P content correlated with yield, and soil P availability in the rhizosphere increased after co-inoculation in Santo Antônio de Goiás. These findings complement previous research efforts and have led to the validation and registration of the first Brazilian inoculant formulated with Bacillus strains for maize, effectively enhancing and P grain content. [ABSTRACT FROM AUTHOR]

Clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 virus was detected in the South American sea lions found dead in Santa Catarina, Brazil, in October 2023. Whole genome sequencing and comparative phylogenetic analysis were conducted to investigate the origin, genetic diversity, and zoonotic potentials of the H5N1 viruses. The H5N1 viruses belonged to the genotype B3.2 of clade 2.3.4.4b H5N1 virus, which was identified in North America and disseminated to South America. They have acquired new amino acid substitutions related to mammalian host affinity. Our study provides insights into the genetic landscape of HPAI H5N1 viruses in Brazil, highlighting the continuous evolutionary processes contributing to their possible adaptation to mammalian hosts. [ABSTRACT FROM AUTHOR]

Purpose: To obtain evidence of the clinical validity of the nursing diagnosis (ND) risk for disturbed maternal–fetal dyad in high‐risk pregnancy. Method: Causal validation of the ND through a case–control study performed in a university hospital with 155 high‐risk pregnant women: 31 cases and 124 controls. A causal association was found between the ND etiological factors and the occurrence of disruption of the symbiotic maternal–fetal dyad; an association was verified when the etiological factor presented a p‐value <0.05 and odds ratio >1. Findings: The risk factor absent–inadequate prenatal care; populations at risk, such as young‐advanced maternal age and economically disadvantaged pregnant women; and association conditions, such as maternal conditions and compromised fetal oxygen transport, increased the outcome likelihood. The associated condition maternal illnesses appeared as a protective factor. Conclusions: Evidence of clinical validity of the ND risk for disturbed maternal–fetal dyad was obtained, and an association between etiological factors and disruption of the symbiotic maternal–fetal dyad was found. Implications for nursing practice: The results contribute to advance scientific knowledge in nursing teaching, research, and practice and support the nursing process in high‐risk pregnancies. [ABSTRACT FROM AUTHOR]

In Brazil, many women are victims of different forms of domestic violence, which can be physical, psychological, moral, sexual and patrimonial. Women victims of domestic violence tend to look for close people to ask for help to get out of the situation, therefore, an informal support network can be an important tool for women to feel protected and ask for help from public organizations. Given that solidarity economic enterprises (SEE) formed only by women are a space for women to strengthen each other, where they socialize and can create bonds, they can also serve as an informal support network for the women who form them, in addition to fostering their financial autonomy. The objective of this article is to identify whether SEE can be part of a support network for women, from the perspective of the women who form them. To this end, three SEE of women were investigated in the brazilian municipality of Araraquara, which has an important history of social movements and public policies aimed at the social and solidarity economy. From the semi-structured interviews carried out with 11 women from three of these SEE, it was possible to obtain results that explain what happens in the empirical field in relation to the theory, such as that women feel comfortable and trust each other, but at the same time At the same time, they do not identify patrimonial violence as violence. [ABSTRACT FROM AUTHOR]

In an effort to enhance the quality of mechanized endodontic instruments, various thermal treatment methods, and design modifications have been suggested. However, upon evaluation, these endodontic instruments may exhibit microscopic irregularities. The objective of this in vitro study was to analyze the cutting capacity, surface finish, and mechanical properties of Nickel-Titanium 25/.04 Rotate (VDW GmbH, Munich, Germany) and LOGIC 2 (Easy Equipamentos Odontológicos, Belo Horizonte, MG, Brazil) rotary instruments. Twenty rotary instruments were divided into 2 groups: GR, the group with ROTATE instruments (n = 10); and GL2, the group with LOGIC 2 instruments (n = 10). They were evaluated for roughness, using a profilometer, for bending resistance, buckling resistance, and cutting capacity using a universal testing machine, as well as for torsional strength (torque and angular deflection) using a torquemeter. The instruments were visualized before and after the mechanical tests through scanning electron microscopy. GR showed better surface finish in terms of roughness, greater cutting capacity, and greater angular deflection than GL2 (P <.05). However, GL2 showed better flexibility than GR (P <.05). GL2 and GR did not show statistically significant differences in terms of buckling and torque (P >.05). The ROTATE and LOGIC 2 rotary instruments differed in their surface finish, cutting capacity, and mechanical properties, except for their buckling resistance and required fracture torque. [ABSTRACT FROM AUTHOR]

Copyright of Revista Foco (Interdisciplinary Studies Journal) is the property of Revista Foco and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Foco (Interdisciplinary Studies Journal) is the property of Revista Foco and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Mango is the fruit most exported by Brazil, with a significant increase in cultivated area in recent years. However, the orchards have been made up of seedlings produced by the grafting process, but without identifying the most suitable rootstock for each cultivar, which affects the competitiveness of mango farming, since the rootstock affects, among other factors, the growth and nutrient absorption from the canopy cultivar. The objective of this study was to evaluate the nutritional status and mineral nutrition of 'Palmer,' 'Tommy Atkins,' 'Kent' and 'Keitt' mango seedlings grafted onto the polyembryonic rootstocks Capucho, Coquinho and Espada. The experiment was carried out between October 2019 and May 2020 at the Fruit Growing Nursery of the Agricultural Sciences Campus of the Federal University of Vale do São Francisco (UNIVASF), in Petrolina-PE, in a 3 × 4 factorial scheme, corresponding to three polyembryonic rootstocks (Espada, Capucho and Coquinho) and four crown cultivars ('Palmer,' 'Keitt,' 'Kent' and 'Tommy Atkins'), with five replications of ten plants each. Leaf contents of macronutrients (N, P, K, Ca), micronutrients (Cu and Fe) and silicon depend on the scion (Tommy Atkins, Palmer, Keitt and Kent) x rootstock (Espada, Capucho and Conquinho) combination. The leaf contents of S, Mg, B, Mn and Mo in the scion are affected by the rootstock adopted for mango propagation In general, for macro and micronutrient absorption purposes, the sword rootstock and the 'Keitt' cultivar are the best combination for most of the variables analyzed in the research. The effect of rootstock on the nutritional status of scion cultivars (Tommy Atkins, Palmer, Keitt and Kent) must be taken into consideration when interpreting crop nutrition. [ABSTRACT FROM AUTHOR]

Introduction: Hepatocellular carcinoma (HCC) carcinogenesis is not yet fully known. Insulin-like growth factor-1 receptor (IGF-1R) can translocate to the nucleus and modulate cellular growth, possibly participating in HCC development and aggressiveness. This study aimed to evaluate the immunoexpression of IGF-1R in HCC, the cellular compartment involved, and its association with clinicopathological parameters and clinical outcomes. Methods: Liver specimens from 111 HCC patients who underwent liver transplantation or partial surgical resections at a Brazilian referral hospital center were studied. IGF-1R expression was determined by immunohistochemistry, clinical data were collected from medical records, and pathological parameters were obtained from path review. Results: IGF-1R nuclear expression was higher in the tumor than in the adjacent cirrhosis (p < 0.001). The odds of IGF-1R expression in the nucleus compared to the membrane are lower in the cirrhosis condition than in the tumor, suggesting an increase in the prevalence of nucleus expression relative to the membrane from cirrhosis to tumor. There was an association between IGF-1R nuclear expression in HCC and the moderate/poor grade of histologic differentiation (p < 0.001). However, long-term clinical outcomes were not associated with IGF-1R nuclear expression. Conclusion: The data presented here suggest the role of IGF-1R in HCC progression and carcinogenesis as its expression increases in the nucleus relative to the membrane, from cirrhosis to tumor, and it was associated with a poorer differentiated tumor grade. Further research is awaited to fully understand the mechanisms underlying this association. [ABSTRACT FROM AUTHOR]

This study investigated the impact of micropollutants on fish health from Segredo hydroelectric reservoir (HRS) along the Iguaçu River, Southern Brazil, contaminated by urban, industrial, and agricultural activities. This is the first comprehensive study assessment in the river after the severe drought in the 2020s in three fish species from different trophic levels Astyanax spp. (water column depth/omnivorous), Hypostomus commersoni (demersal/herbivorous), and Pimelodus maculatus (demersal/omnivorous). Animals, water, and sediment samples were collected from three distinct sites within the reservoir: Floresta (upstream), Iratim (middle), and Station (downstream). The chemical analysis revealed elevated concentrations of metals (Al, Cu, Fe) and the metalloid As in water, or Cu, Zn, and As in sediment, surpassing Brazilian regulatory limits, while the organic pollutants as DDT, PAHs, PCBs, and PBDEs were found under the Brazilian regulatory limits. The metal bioaccumulation was higher in gills with no significant differences among sites. The species Astyanax spp. and H. commersoni displayed variations in hepatosomatic index (HSI) and P. maculatus in the condition factor index (K) between sites, while adverse effects due to micropollutants bioaccumulation were observed by biochemical, genotoxic, and histopathological biomarkers. The principal component analysis and integrated biomarker response highlighted the upstream site Floresta as particularly inhospitable for biota, with distinctions based on trophic level. Consequently, this multifaceted approach, encompassing both fish biomarkers and chemical analyses, furnishes valuable insights into the potential toxic repercussions of micropollutant exposure. These findings offer crucial data for guiding management and conservation endeavors in the Iguaçu River. [ABSTRACT FROM AUTHOR]

Selecting adapted hybrids with greater efficiency in the use and return of nutrients is essential to ensure the success of forestry activities. Although topics on the nutritional sustainability of eucalypt biomass harvesting have frequently been discussed, few studies have focused on short rotation eucalypt clonal plantations (aimed at energy production), especially in conditions of nutrient scarcity and water limitations in Brazil. Therefore, our objective was to evaluate the nutritional efficiency and sustainability (for nitrogen (N), phosphorus (P) and potassium (K)) of six eucalypt clones in short rotation cultivation in the north-east of Brazil, considering different harvesting scenarios and using the Eucalyptus urophylla species as a reference, which is traditionally planted in the study region. Direct quantification of the biomass of 21 trees of each clone was carried out at 5 years of age. The clones did not affect the accumulation of total biomass (on average, 199.9 Mg ha−1). The 1296 and 1355 clones provided lower biomass export and greater nutritional efficiency, favouring an increase in the potential number of rotations (PNR) for P and a reduction in the N removal rate (RR). However, the VM58 clone showed higher biomass export and lower PNR. Thus, clones 1296 and 1355 are more favourable, while clone VM58 is less favourable to nutritional sustainability under the studied conditions. Nitrogen and K may cause productivity limitations in future rotations in whole-tree harvesting systems. Adopting more conservationist harvesting systems with removing only the stemwood or stemwood with bark can optimise the potential of clones, minimise the need to add fertilisers and ensure maintenance of the site's productivity. [ABSTRACT FROM AUTHOR]

The north region of Brazil is characterized by significant vulnerabilities, notably surpassing national poverty indicators. These disparities exacerbated the impact of respiratory illnesses on the healthcare system during the COVID-19 pandemic, particularly in areas with limited healthcare resources, inadequate infrastructure, and barriers to healthcare access. The crisis was further influenced by multiple lineages that emerged as significant virus variants associated with increased transmissibility. Within this context, our ecological study focused on analyzing the epidemiological evolution of COVID-19 in the state of Acre. We constructed time-series trends in incidence, lethality, and mortality from March 2020 to December 2022 using the Prais–Winsten regression model. Our findings revealed that in 2020, there was an increasing trend in incidence, while mortality and lethality continued to decrease (p < 0.05). In the following year, both incidence and mortality decreased, while lethality increased at a rate of 1.02% per day. By the end of 2022, trends remained stationary across all rates. These results underscore the importance of ongoing surveillance and adaptive public health measures to bolster the resilience of healthcare systems in remote and vulnerable regions. Indeed, continuous monitoring of the most predominant SARS-CoV-2 lineages and their dynamics is imperative. Such proactive actions are essential for addressing emerging challenges and ensuring effective responses to adverse situations. [ABSTRACT FROM AUTHOR]

The Chikungunya virus (CHIKV) presents global health challenges, with Brazil experiencing outbreaks since its introduction in 2014. In 2023, following a CHIKV outbreak in Minas Gerais (MG), social media was used to optimize an entomological survey aimed at identifying vectors and viral lineages and assessing insecticide resistance. Following Instagram posts, residents with suspected CHIKV infection were able to schedule mosquito aspirations. In total, 421 mosquitoes (165 Aedes aegypti and 256 Culex quinquefasciatus) were captured from 40 households in Salinas city (MG) and tested for the Dengue, Zika, and Chikungunya viruses through RT-qPCR. Twelve of 57 pools (10 Ae. aegypti and two Cx. quinquefasciatus) tested positive for CHIKV RNA. Viral RNA was also detected in the heads of nine Ae. aegypti, indicating viral dissemination but not in Cx. quinquefasciatus. Genome sequencing yielded the first near-complete genome from the 2023 outbreak, unveiling that the CHIKV strain belonged to the East/Central/South African (ECSA) genotype. Additionally, genetic analyses revealed high frequencies of kdr alleles, including in CHIKV-infected mosquitoes, suggesting resistance to pyrethroid insecticides in this Ae. aegypti population. Social media was important for guiding mosquito-capture efforts in CHIKV transmission hotspots, thus optimizing the opportunity for viral detection. These findings emphasize the urgent need for innovative vector studies and control strategies, as well as interdisciplinary approaches in public health interventions. [ABSTRACT FROM AUTHOR]

We present an educational game for teaching physics, "Spies." The game is based on the popular boardgame "Codenames." It is useful as a didactic tool to promote and improve student engagement. "Spies" is practical, fast and requires very little physical resources, which makes it ideal for high school teaching and viable in most diverse school realities.

Introduction: This study aimed to systematically analyze and describe the main challenges of congenital heart diseases (CHDs) in the countries in the Amazon region. Methods: The methodology followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist utilizing the Medline, Embase, Lilacs, and Google Scholar databases. The inclusion criteria were articles addressing any topic involving CHD in the Amazon region. Incomplete articles, book chapters, lectures, conference abstracts, and editorials were excluded. Results: Nine studies were identified, 7 of which were published in the last decade and were of Colombian and Brazilian origin. The methodology of the studies was cross-sectional and ecological, evaluating the regional and epidemiological factors, challenges to diagnosis and treatment, multidisciplinary team challenges, and the impact of the COVID-19 pandemic. Studies carried out by surgeons demonstrate more existing data regarding the challenges of the health-care system. Conclusions: There is growing interest in analyzing the situation of CHD in the region. However, only a few studies are available, mostly on ecological and cross sectional analysis. These records show the lack of hospital infrastructure and multidisciplinary teams for the diagnosis and treatment of CHD in the Amazon region; we see an initiative by specialists from two countries (Colombia and Brazil) to demonstrate the difficulties by seeking international training programs and government aid to improve the health system situation. [ABSTRACT FROM AUTHOR]

This research aimed to identify the relationships that the Benedito Leite Public Library maintains with memory, cultural heritage and sociability in São Luís, based on the arguments of users who participate in the educational services of the institution. This is an exploratory and descriptive research, with a quantitative and qualitative approach, which made use of systematic observation with a logbook and mixed questionnaires of 10 questions, whose data collection had a sample universe of 62 users who participated in educational services. We point out that, no matter how different the profiles of the users of the Benedito Leite Public Library are, their testimonies converge on the importance of the institution for the preservation of history, memory and heritage. By mediating and disseminating cultural heritage through its educational services, the Library allows the reconstruction of the memory of the citizens of São Luís and the creation of links, made explicit by the symbolic and affective contours between its visitors, users, and professionals. [ABSTRACT FROM AUTHOR]

Objective This article aimed to report a temporal series of respiratory distress syndrome (RDS)-associated neonatal mortality rates in preterm live births in São Paulo state, Brazil, and to identify social, maternal, and neonatal characteristics associated with these deaths. Study Design This is a population-based study of all live births with gestational age (GA) between 22 and 36 weeks, birth weight ≥400 g, without congenital anomalies from mothers living in São Paulo state during 2004 to 2015. RDS-associated neonatal mortality was defined as death up to 27 days after birth with ICD-10 codes P22.0 or P28.0. RDS-associated neonatal mortality rate (annual percent change [APC] with 95% confidence intervals [95% CIs]) was analyzed by Prais–Winsten. Kaplan–Meier estimator identified the time after birth that the RDS-associated neonatal death occurred. Poisson's regression model compared social maternal and neonatal characteristics between preterm live births that survived the neonatal period and those with RDS-associated neonatal deaths, with results expressed in incidence rate ratio and 95% CI. Results A total of 645,276 preterm live births were included in the study, of which 612,110 survived and 11,078 had RDS-associated neonatal deaths. RDS-associated neonatal mortality rate was 17.17 per thousand preterm live births, with a decreasing annual trend (APC: −6.50%; 95% CI: −9.11 to −3.82%). The median time of these deaths was 48 hours after birth. The following risk factors for RDS-associated neonatal death were identified: maternal schooling ≤7 years (1.18; 1.09–1.29), zero to three prenatal care visits (1.25; 1.18–1.32), multiple pregnancy (1.24; 1.16–1.33), vaginal delivery (1.29; 1.22–1.36), GA 22 to 27 weeks (106.35; 98.36–114.98), GA 28 to 31 weeks (20.12; 18.62–21.73), male sex (1.16; 1.10–1.22), and 5-minute Apgar scores of 0 to 3 (6.74; 6.08–7.47) and 4 to 6 (3.97; 3.72–4.23). Conclusion During the study period, RDS-associated neonatal mortality rates showed significant reduction. The relationship between RDS-associated neonatal deaths and social, maternal, and neonatal factors suggests the need for perinatal strategies to reduce prematurity and to improve the initial management of preterm infants. Key Points RDS is associated with preterm live births. Impact of RDS-associated neonatal mortality in middle-income countries is scarce. Qualified perinatal care can reduce RDS-associated neonatal mortality. [ABSTRACT FROM AUTHOR]

Dengue, a disease with multifactorial determinants, is linked to population susceptibility to circulating viruses and the extent of vector infestation. This study aimed to analyze the temporal trends of dengue cases and deaths in Belo Horizonte, Minas Gerais, Brazil, from 2007 to 2020. Data from the Notifiable Diseases Information System (Sinan) were utilized for the investigation. To assess the disease's progression over the study period and predict its future incidence, time series analyses were conducted using a generalized additive model (GAM) and a seasonal autoregressive integrated moving average (SARIMA) model. Over the study period, a total of 463,566 dengue cases and 125 deaths were reported. Notably, there was an increase in severe cases and deaths, marking hyperendemics characterized by simultaneous virus circulation (79.17% in 2016–50% in 2019). The generalized additive model revealed a non-linear pattern with epidemic peaks in 2010, 2013, 2016, and 2019, indicating an explosive pattern of dengue incidence. The SARIMA (3,1,1) (0,0,0)12 model was validated for each year (2015 to 2019). Comparing the actual and predicted numbers of dengue cases, the model demonstrated its effectiveness for predicting cases in the municipality. The rising number of dengue cases emphasizes the importance of vector surveillance and control. Enhanced models and predictions by local health services will aid in anticipating necessary control measures to combat future epidemics. [ABSTRACT FROM AUTHOR]

Aims The present study aimed to use a conventional and metagenomic approach to investigate the microbiological diversity of water bodies in a network of drainage channels and rivers located in the central area of the city of Belém, northern Brazil, which is considered one of the largest cities in the Brazilian Amazon. Methods and results In eight of the analyzed points, both bacterial and viral microbiological indicators of environmental contamination—physical–chemical and metals—were assessed. The bacterial resistance genes, drug resistance mechanisms, and viral viability in the environment were also assessed. A total of 473 families of bacteria and 83 families of viruses were identified. Based on the analysis of metals, the levels of three metals (Cd, Fe, and Mn) were found to be above the recommended acceptable level by local legislation. The levels of the following three physicochemical parameters were also higher than recommended: biochemical oxygen demand, dissolved oxygen, and turbidity. Sixty-three bacterial resistance genes that conferred resistance to 13 different classes of antimicrobials were identified. Further, five mechanisms of antimicrobial resistance were identified and viral viability in the environment was confirmed. Conclusions Intense human actions combined with a lack of public policies and poor environmental education of the population cause environmental degradation, especially in water bodies. Thus, urgent interventions are warranted to restore the quality of this precious and scarce asset worldwide. [ABSTRACT FROM AUTHOR]

Simple Summary: We evaluate the downstream effects of the Epithelial-to-Mesenchymal Transition (EMT) transcription factors, ZEB1 and SNAI1, and analyze their potential significance as biomarkers for increased aggressiveness and immune response in prostate cancer (PCa). We used two commercial expression profiling panels to examine a primary PCa cohort (n = 51) and identified changes in gene expression linked to downstream pathways associated with biochemical recurrence and increased clinical risk. Genes such as COL1A1, COL1A2, and COL3A1, which are implicated in the tumor microenvironment, and immune-related genes, such as THY1, IRF5, and HLA-DRA, exhibited significant expression level changes. Enrichment analysis identified pathways associated with angiogenesis, TGF-beta, EMT, and UV response in PCa progression. Confirmatory analyses conducted using public domain data demonstrated the downstream impacts of ZEB1 and SNAI1 on pathways and immune responses, highlighting their potential influence on immune modulation in PCa. Future treatment strategies aimed at modulating EMT may enhance immune cell infiltration toward an anti-tumorigenic phenotype. Prostate cancer (PCa) is an immunologically cold tumor and the molecular processes that underlie this behavior are poorly understood. In this study, we investigated a primary cohort of intermediate-risk PCa (n = 51) using two NanoString profiling panels designed to study cancer progression and immune response. We identified differentially expressed genes (DEGs) and pathways associated with biochemical recurrence (BCR) and clinical risk. Confirmatory analysis was performed using the TCGA-PRAD cohort. Noteworthy DEGs included collagens such as COL1A1, COL1A2, and COL3A1. Changes in the distribution of collagens may influence the immune activity in the tumor microenvironment (TME). In addition, immune-related DEGs such as THY1, IRF5, and HLA-DRA were also identified. Enrichment analysis highlighted pathways such as those associated with angiogenesis, TGF-beta, UV response, and EMT. Among the 39 significant DEGs, 11 (28%) were identified as EMT target genes for ZEB1 using the Harmonizome database. Elevated ZEB1 expression correlated with reduced BCR risk. Immune landscape analysis revealed that ZEB1 was associated with increased immunosuppressive cell types in the TME, such as naïve B cells and M2 macrophages. Increased expression of both ZEB1 and SNAI1 was associated with elevated immune checkpoint expression. In the future, modulation of EMT could be beneficial for overcoming immunotherapy resistance in a cold tumor, such as PCa. [ABSTRACT FROM AUTHOR]

Copyright of Revista de Enfermagem e Atenção à Saúde (REAS) is the property of Revista de Enfermagem e Atencao a Saude - Reas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To estimate the prevalence and factors associated with Driving Under the Influence of Alcohol (DUIA) among car drivers and motorcyclists in Brazil and to evaluate the association between DUIA and self-reported Road Traffic Injuries (RTIs) in these groups. A cross-sectional study was conducted using data from adults aged 18 or older who participated in the 2019 National Health Survey. Probability sampling was used to recruit participants, and data collection was carried out through home visits. Data from 31,246 car drivers and 21,896 motorcyclists were analyzed. Key indicators included the proportion (%) of car drivers who consumed alcohol and then drove in the past 12 months and the proportion (%) of motorcyclists who consumed alcohol and then drove in the past 12 months. Multiple Poisson regression was used to determine factors associated with DUIA and the association of this variable with RTIs in both groups. DUIA prevalence was 9.4% (95% Confidence Interval [95% CI] = 8.8–10.0) among car drivers and 11.2% (95% CI = 10.4–12.1) among motorcyclists. Among car drivers, DUIA prevalence was higher in men, young adults, those without a spouse/partner, and lower in individuals with lower income and education level. Among motorcyclists, DUIA prevalence was higher in men, young adults, those living outside the capitals and metropolitan regions, and lower in individuals with lower income. DUIA increased the prevalence of self-reported RTIs in the previous 12 months among car drivers and motorcyclists. A high prevalence of DUIA was evident among drivers, particularly motorcyclists. The DUIA was more prevalent among men and young adults. The DUIA was associated with an increased magnitude of self-reported RTIs among car drivers and motorcyclists. Despite the extensive legislation for zero tolerance toward DUIA in the country, actions need stricter enforcement. [ABSTRACT FROM AUTHOR]

Syagrus coronata (Mart.) Becc. belongs to the Arecaceae family. It is a species native to Brazil of ecological, social, and economic importance. To date, there are few mitochondrial genomes in Arecaceae (Cocos nucifera and Phoenix dactylifera L.), and studies of the mitochondrial genome are essential to understand the evolution of the Arecaceae family. This study reports and compares the newly sequenced genome of S. coronata. Single-end and paired-end reads were used to obtain de novo contigs. The mitochondrial contigs were selected using C. nucifera as a reference and were merged using mate paired-end reads. The mitochondrial genome showed 642,817 bp, circular structure, containing 73 predicted functional genes, including four ribosomal RNA (rRNA) genes, 27 transfer RNA (tRNA) genes, and 42 coding protein genes. Large chloroplast genomic fragments were identified in the mitochondrial genome, and large DNA repetitive fragments were into intergenic space regions. Arecaceae mitochondrial genomes showed partial similarities in size, genome structure, and gene content. However, they exhibited numerous rearrangements. In summary, (1) we sequenced the mitochondrial genome of S. coronata and compared with other mitogenomes of Arecaceae. (2) Genomic rearrangements and gene transfer have been identified from the chloroplast genome to the mitochondrial genome. (3) The mitochondrial genome of Arecareae showed similarities in size, structure, and gene content. (4) The expansion of intergenic space size occurs due to the insertion of genes originating from the nucleus. [ABSTRACT FROM AUTHOR]