1. Prenatal disorders and congenital Zika syndrome in squirrel monkeys.
- Author
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Imbeloni AA, de Alcantara BN, Coutinho LN, de Azevedo Scalercio SRR, Carneiro LA, Oliveira KG, Filho AJM, de Brito Simith Durans D, da Silva WB, Nunes BTD, Casseb LMN, Chiang JO, de Carvalho CAM, Machado MB, Quaresma JAS, de Almeida Medeiros DB, and da Costa Vasconcelos PF
- Subjects
- Animals, Brazil epidemiology, Female, Pregnancy, Fetal Diseases epidemiology, Fetal Diseases metabolism, Fetal Diseases veterinary, Fetal Diseases virology, Microcephaly embryology, Microcephaly metabolism, Microcephaly virology, Monkey Diseases epidemiology, Monkey Diseases metabolism, Monkey Diseases virology, Saimiri virology, Zika Virus metabolism, Zika Virus Infection epidemiology, Zika Virus Infection metabolism, Zika Virus Infection veterinary
- Abstract
During the Zika virus (ZIKV) outbreak in Brazil (2015-2016), the clinical manifestations associated with its infection were complex and included miscarriage and congenital malformations, not previously described. In this study, we evaluated the prenatal conditions of pregnant female squirrel monkeys (Saimiri collinsi) infected during different gestational thirds (GTs) and assessed all clinical aspects, diagnostic imaging, viremia and the immune response. In our study, 75% of the infected animals in the 1st GT group had significant clinical manifestations, such as miscarriage and prolonged viremia associated with a late immune response. Consequently, their neonates showed fetal neuropathology, such as cerebral hemorrhage, lissencephaly or malformations of the brain grooves, ventriculomegaly, and craniofacial malformations. Thus, our study demonstrated the relevance of pregnant squirrel monkeys as a model for the study of ZIKV infection in neonates due to the broad clinical manifestations presented, including the typical congenital Zika syndrome manifestations described in humans.
- Published
- 2021
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