1. Dammarane-type triterpenes from the Brazilian medicinal plant Cordia multispicata.
- Author
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Kuroyanagi M, Kawahara N, Sekita S, Satake M, Hayashi T, Takase Y, and Masuda K
- Subjects
- Brazil, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Stereoisomerism, Triterpenes chemistry, Triterpenes pharmacology, Dammaranes, Cordia chemistry, Plants, Medicinal chemistry, Triterpenes isolation & purification
- Abstract
From the Brazilian medicinal plant Carucaá (Cordia multispicata), oleanane- and ursane-type triterpenoids were previously reported as anti-androgenic constituents of the plant. In this study, purification of the polar elements of the EtOAc-soluble fraction of the plant revealed nine novel dammarane-type triterpenes, named cordianols A-I (1-9) along with the known compound cordialin A (10). The structures of these new compounds were elucidated by means of spectral methods including HRFABMS, (1)H NMR, (13)C NMR, and 2D NMR (HMQC, HMBC, NOESY). Absolute configuration at C-23 of compound 7 was determined by an excitone chirality method. Some of these new compounds revealed a hemiketal structure on the A ring and a hydroxylated or epoxidated 20(22)-(E)-ene side chain and showed weak anti-androgenic activity.
- Published
- 2003
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