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1. Isolation and identification of compounds from Brazilian propolis which enhance macrophage spreading and mobility.

Author

Tatefuji T, Izumi N, Ohta T, Arai S, Ikeda M, and Kurimoto M

Subjects
Animals, Brazil, Cell Movement drug effects, Chromatography, High Pressure Liquid, In Vitro Techniques, Magnetic Resonance Spectroscopy, Mice, Mice, Inbred Strains, Propolis chemistry, Spectrometry, Mass, Fast Atom Bombardment, Stimulation, Chemical, Chemotactic Factors pharmacology, Macrophages, Peritoneal drug effects, Propolis pharmacology
Abstract

Brazilian propolis is known to induce the activation of murine effector cells. We isolated and identified six compounds from a water-soluble extract of Brazilian propolis, all of which have enhancing effects on the spreading and mobility of murine macrophages. These compounds were identified as caffeoylquinic acid-derivatives, namely, 5-caffeoylquinic acid (1), chlorogenic acid (2), 4-caffeoylquinic acid (3), 4,5-dicaffeoylquinic acid (4), 3,5-dicaffeoylquinic acid (5) and 3,4-dicaffeoylquinic acid (6).

Published
1996
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