1. Lactotransferrin gene functional polymorphisms do not influence susceptibility to human immunodeficiency virus-1 mother-to-child transmission in different ethnic groups.
- Author
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Zupin L, Polesello V, Coelho AV, Boniotto M, Arraes LC, Segat L, and Crovella S
- Subjects
- Acquired Immunodeficiency Syndrome ethnology, Adolescent, Brazil ethnology, Child, Cohort Studies, Ethnicity genetics, Female, Gene Frequency genetics, Genotyping Techniques, Humans, India ethnology, Infant, Newborn, Italy ethnology, Male, Real-Time Polymerase Chain Reaction, Retrospective Studies, Zimbabwe ethnology, Acquired Immunodeficiency Syndrome transmission, Genetic Predisposition to Disease genetics, HIV-1 genetics, Infectious Disease Transmission, Vertical, Lactoferrin genetics, Polymorphism, Single Nucleotide genetics
- Abstract
Lactotransferrin, also known as lactoferrin, is an iron binding glycoprotein that displays antiviral activity against many different infectious agents, including human immunodeficiency virus (HIV)-1. Lactotransferrin is present in the breast milk and in the female genitourinary mucosa and it has been hypothesised as a possible candidate to prevent mother-to-child HIV-1 transmission. To verify if two functional polymorphisms, Thr29Ala and Arg47Lys, in the lactotransferrin encoding gene (LTF) could affect HIV-1 infection and vertical transmission, a preliminary association study was performed in 238 HIV-1 positive and 99 HIV-1 negative children from Brazil, Italy, Africa and India. No statistically significant association for the Thr29Ala and Arg47Lys LTF polymorphisms and HIV-1 susceptibility in the studied populations was found. Additionally LTF polymorphisms frequencies were compared between the four different ethnic groups.
- Published
- 2015
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