1. Overprescription of short-acting β2 agonists: reflections from the SABINA study in Brazil.
- Author
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Antila, Martti Anton, Souza-Machado, Adelmir, Gregório, Marcelo Gervilla, Cruz, Álvaro A., Angelini, Luciene, Beekman, Maarten J. H. I., Zonzin, Gilmar Alves, and Rabahi, Marcelo Fouad
- Subjects
INAPPROPRIATE prescribing (Medicine) ,ASTHMATICS ,HEALTH education ,MEDICAL care ,BRONCHODILATOR agents - Abstract
Objective: To assess prescription patterns for short-acting β
2 agonists (SABAs) and other asthma medications in asthma patients treated by specialists and participating in the SABA use IN Asthma (SABINA)studyin Brazil. Methods: This was an observational, cross-sectional study conducted at five sites in different regions of Brazil. The primary endpoints were to record SABA prescriptions and obtain data on over-the-counter (OTC) SABA purchases at the pharmacy. Results: Data on 218 asthma patients were analyzed. Of those 218 patients, 80.3% were prescribed SABAs in addition to their maintenance therapy, with a mean of 11.2 SABA canisters in the previous 12 months. Of those patients, 71.4% were prescribed ≥ 3 canisters and 42.2% were prescribed ≥ 10 canisters. None of the patients were prescribed SABA monotherapy. A total of 14.2% of the patients reported purchasing SABAs OTC at a pharmacy without a prescription. Of those, 48.4% purchased ≥ 3 SABA canisters. A fixed-dose combination of an inhaled corticosteroid and a long-acting β2 agonist was prescribed to 95.0% of the patients. In the year before the study visit, 45.0% of the patients received at least one course of oral corticosteroid burst treatment. Asthma was well controlled in 43.1% of the patients, partly controlled in 34.9%, and uncontrolled in 22.0%. Patients reported a mean of 1.1 severe asthma exacerbations, with 49.1% experiencing 1 or more severe exacerbations. Conclusions: Overprescription and OTC purchases of SABAs are common in Brazil, possibly leading to the need for courses of oral corticosteroids. The health care community should collaborate to implement evidence-based recommendations and promote health education to improve asthma management in Brazil. [ABSTRACT FROM AUTHOR]- Published
- 2024
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