1. Performance of the QuantiFERON-TB gold interferon gamma release assay among HIV-infected children in Botswana.
- Author
-
Cruz AT, Marape M, Graviss EA, and Starke JR
- Subjects
- Adolescent, Botswana epidemiology, Child, Child, Preschool, Cohort Studies, Female, HIV Infections epidemiology, Humans, Infant, Latent Tuberculosis epidemiology, Male, HIV Infections complications, Interferon-gamma Release Tests methods, Latent Tuberculosis complications, Latent Tuberculosis diagnosis
- Abstract
Interferon gamma release assays (IGRAs) are poorly studied in HIV-infected children. The authors prospectively evaluated QuantiFERON-TB Gold results and family-described tuberculosis (TB) risk factors in 100 HIV-infected children in Botswana. Median age was 10.2 years; 58 were girls, 92 had received the Bacillus Calmette-Guérin (BCG) vaccine, 98 were receiving antiretroviral therapy, and the median body mass index was 15.8 kg/m(2). Eighty-nine children had undetectable viral loads and the median CD4 count was 962 cells/mm(3). Eighteen children had been treated for TB in the last 3 years. In the last 3 years, 36 (including 9 with TB) had contact with persons with TB (26 within/15 outside the home and 5 had >1 contact). In all, 96 children had negative IGRAs, 3 were indeterminate, and 1 was positive. The positive IGRA was reported in a child treated for TB prior to 3 years. Interferon γ release assay positivity was rare in this pediatric cohort living in an area with a high prevalence of TB., (© The Author(s) 2014.)
- Published
- 2015
- Full Text
- View/download PDF