A recent report from Brigham and Women's Hospital in Boston, Massachusetts discusses the potential of nanodiscs in drug delivery and structural biology. Nanodiscs are biocompatible HDL particles that have advantages such as small size, extended circulation time, stability, tolerability, and tissue targeting properties. However, there are challenges in their use as drug carriers, including the costly and laborious process of isolation and purification of endogenous HDL. The report also explores the utility of nanodiscs in structural biology, particularly in investigating virus-cell interactions and characterizing membrane proteins. The researchers evaluate the potential for clinical translation and future applications of nanodiscs. [Extracted from the article]