1. The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects.
- Author
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Sharma R, Prudente S, Andreozzi F, Powers C, Mannino G, Bacci S, Gervino EV, Hauser TH, Succurro E, Mercuri L, Goheen EH, Shah H, Trischitta V, Sesti G, and Doria A
- Subjects
- Biomarkers blood, Body Mass Index, Boston, Cardiovascular Diseases blood, Cardiovascular Diseases physiopathology, Case-Control Studies, Coronary Artery Disease blood, Coronary Artery Disease physiopathology, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 physiopathology, Female, Genetic Predisposition to Disease, Humans, Hypertension genetics, Italy, Logistic Models, Male, Odds Ratio, Phenotype, Risk Assessment, Risk Factors, Cardiovascular Diseases genetics, Cholesterol, HDL blood, Coronary Artery Disease genetics, Diabetes Mellitus, Type 2 genetics, Insulin Receptor Substrate Proteins genetics, Insulin Resistance genetics, Polymorphism, Single Nucleotide, Triglycerides blood
- Abstract
Objective: SNP rs2943641 near the insulin receptor substrate 1 (IRS1) gene has been found to be associated with type 2 diabetes (T2D) and insulin-resistance in genome-wide association studies. We investigated whether this SNP is associated with cardiovascular risk factors and coronary artery disease (CAD) among diabetic individuals., Methods: SNP rs2943641 was typed in 2133 White T2D subjects and tested for association with BMI, serum HDL cholesterol and triglycerides, hypertension history, and CAD risk., Results: HDL cholesterol decreased by 1mg/dl (p = 0.004) and serum triglycerides increased by 6 mg/dl (p = 0.016) for each copy of the insulin-resistance allele. Despite these effects, no association was found with increased CAD risk (OR = 1.00, 95% CI 0.88-1.13)., Conclusions: The insulin-resistance and T2D locus near the IRS1 gene is a determinant of lower HDL cholesterol among T2D subjects. However, this effect is small and does not translate into a detectable increase in CAD risk in this population., (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2011
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