1. Protection of European domestic pigs from virulent African isolates of African swine fever virus by experimental immunisation.
- Author
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King K, Chapman D, Argilaguet JM, Fishbourne E, Hutet E, Cariolet R, Hutchings G, Oura CA, Netherton CL, Moffat K, Taylor G, Le Potier MF, Dixon LK, and Takamatsu HH
- Subjects
- African Swine Fever immunology, African Swine Fever virology, African Swine Fever Virus classification, African Swine Fever Virus isolation & purification, Animals, Antibodies, Viral blood, Benin, Immunization, Interferon-gamma biosynthesis, Portugal, Sus scrofa virology, Swine, T-Lymphocytes immunology, Uganda, African Swine Fever prevention & control, African Swine Fever Virus immunology, African Swine Fever Virus pathogenicity, Sus scrofa immunology, Viral Vaccines administration & dosage, Viral Vaccines immunology
- Abstract
African swine fever (ASF) is an acute haemorrhagic disease of domestic pigs for which there is currently no vaccine. We showed that experimental immunisation of pigs with the non-virulent OURT88/3 genotype I isolate from Portugal followed by the closely related virulent OURT88/1 genotype I isolate could confer protection against challenge with virulent isolates from Africa including the genotype I Benin 97/1 isolate and genotype X Uganda 1965 isolate. This immunisation strategy protected most pigs challenged with either Benin or Uganda from both disease and viraemia. Cross-protection was correlated with the ability of different ASFV isolates to stimulate immune lymphocytes from the OURT88/3 and OURT88/1 immunised pigs., (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Published
- 2011
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