1. Strong IgG isotypic antibody response in sowdah type onchocerciasis.
- Author
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Brattig NW, Krawietz I, Abakar AZ, Erttmann KD, Kruppa TF, and Massougbodji A
- Subjects
- Antibody Formation, Benin epidemiology, Enzyme-Linked Immunosorbent Assay, Humans, Immunoglobulin G classification, Onchocerciasis blood, Onchocerciasis epidemiology, Reference Values, Antibodies, Helminth blood, Immunoglobulin G blood, Immunoglobulin Isotypes blood, Onchocerciasis immunology
- Abstract
Persons exposed to Onchocerca volvulus express differences in manifestations of onchocerciasis ranging from hyporeactive (generalized) to hyperreactive (sowdah) forms; absence of disease is seen in endemic normal persons. Analysis of the IgG isotypic antibody response to O. volvulus extracts and nonparasite ubiquitous antigens in 92 West Africans revealed highest anti-O. volvulus IgG1 and IgG2 responses in sowdah, high levels in the generalized form, and low antibody levels in endemic normal persons. Nonexposed persons had no antibodies. A significant IgG3 antibody response was detected only in sowdah, while high IgG4 levels occurred in both polar groups but were absent in both control groups. Isotypic responses to antigens unrelated to O. volvulus were similar in all groups but showed higher IgG1 and IgG2 levels in sowdah. Sowdah patients had high levels of Ro/SS-A antibodies, circulating immune complexes, and eosinophil cationic protein. These results document a strong B cell response in African sowdah and indicate variations in immune responsiveness.
- Published
- 1994
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