1. Personalised external aortic root support (PEARS) in Marfan syndrome: analysis of 1-9 year outcomes by intention-to-treat in a cohort of the first 30 consecutive patients to receive a novel tissue and valve-conserving procedure, compared with the published results of aortic root replacement.
- Author
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Treasure T, Takkenberg JJ, Golesworthy T, Rega F, Petrou M, Rosendahl U, Mohiaddin R, Rubens M, Thornton W, Lees B, and Pepper J
- Subjects
- Adult, Aortic Aneurysm diagnosis, Aortic Aneurysm etiology, Belgium, Blood Vessel Prosthesis Implantation adverse effects, Computer-Aided Design, Female, Follow-Up Studies, Heart Valve Prosthesis Implantation, Humans, Intention to Treat Analysis, London, Magnetic Resonance Angiography, Male, Marfan Syndrome diagnosis, Precision Medicine, Prospective Studies, Prosthesis Design, Surgery, Computer-Assisted adverse effects, Surgical Mesh, Time Factors, Treatment Outcome, Young Adult, Aortic Aneurysm surgery, Aortic Valve surgery, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation instrumentation, Marfan Syndrome complications, Surgery, Computer-Assisted instrumentation
- Abstract
Objective: Among people with Marfan syndrome who have a typical aortic root aneurysm, dissection is a characteristic cause of premature death. To pre-empt Type A dissection, composite root replacement with a mechanical valve became the standard of care in the 1980s and 1990s. This is being superseded by valve-sparing aortic root replacement to avoid lifelong anticoagulation. In 2004, a total root and valve-sparing procedure, personalised external aortic support, was introduced. We report here results among the first 30 recipients., Methods: From cross-sectional digital images, the patient's own aorta is modelled by computer aided design and a replica is made in thermoplastic by rapid prototyping. On this, a personalised support of a macroporous polymer mesh is manufactured. The mesh is positioned around the aorta, closely applied from the aortoventricular junction to beyond the brachiocephalic artery. The operation is performed with a beating heart and usually without cardiopulmonary bypass., Results: Between 2004 and 2011, 30 patients, median age 28 years (IQR 20-44) had this operation and have been prospectively followed for 1.4-8.8 years by February 2013. During a total of 133 patient-years there were no deaths or cerebrovascular, aortic or valve-related events. These early outcomes are better than published results for the more radical extirpative root replacement operations., Conclusions: The aortic valve, the root architecture, and the blood/endothelia interface are conserved. The perioperative burden is less and there has been freedom from aortic and valvular events. A prospective comparative study is planned., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.)
- Published
- 2014
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