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Introduction: China has a low incidence of type 1 diabetes mellitus (T1DM); however, based on the large population, the absolute numbers are high. Our aim was to assess the incidence of childhood T1DM in Beijing during 2011–2020, predicted incidence for 2025–2035, and to determine the incidence of diabetic ketosis or diabetic ketoacidosis (DK/DKA) in this population. Methods: Data on patients aged less than 15 years of age with newly diagnosed T1DM between January 1, 2011 and December 31, 2020 was obtained from five tertiary hospitals in Beijing and retrospectively analyzed. Results: In all, 636 children aged less than 15 years were diagnosed with T1DM during 2011–2020. The incidence of T1DM was 3.11–5.46 per 100,000 per year, with an average increase of 5.10% per year. The age-specific incidence for ages 0–4 years, 5–9 years, and 10–14 years was 2.97, 4.69, and 4.68 per 100,000 per year, respectively. The highest average annual increase (7.07%) in incidence was for the youngest age group. DK or DKA was present at the time of diagnosis of T1DM in 84.6% of patients. The age-specific incidence of T1DM among children aged less than 15 years was predicted to be 7.32, 11.4, and 11.52 per 100,000 in 2035 for ages 0–4 years, 5–9 years, and 10–14 years, respectively. Conclusions: The was a gentle increase in the incidence of childhood T1DM during 2011–2020 in Beijing. This increase is expected to continue for the next 15 years. [ABSTRACT FROM AUTHOR]

Background: The incidence of type 1 diabetes mellitus (T1DM) is increasing rapidly worldwide for children of every age group. Materials and Methods: A retrospective analysis of hospital registration data from five tertiary hospitals in Beijing, China, identified 485 patients (210 boys, 275 girls) younger than 15 years of age with newly diagnosed T1DM between 1995 and 2010. Results: From 1995 to 2010, the incidence of T1DM in patients <15 years of age ranged from 0.935-3.26 per 100,000 per year. During this period, the average age-standardized incidence rate was 1.7 per 100,000 per year, and the average annual increase in T1DM incidence was 4.36%. The highest rate increases occurred in boys and in patients <5 years of age. For both genders and all age groups, T1DM incidence increased at an accelerated rate after 2006. By 2020, the incidence of T1DM among children in Beijing is projected to increase by a factor of 1.69. Conclusions: The incidence of T1DM among patients younger than 15 years of age in Beijing increased from 1995 to 2010, with rates growing at an accelerated pace since 2006. Based on recent trends, we project continued rapid growth in the number of new childhood T1DM cases in Beijing. [ABSTRACT FROM AUTHOR]