Search

The occurrence and removal rate of 52 typical pharmaceuticals and personal care products (PPCPs) were investigated in a wastewater treatment plant in Beijing, China. Thirty-three PPCPs were found in the influent, with caffeine (CF, 11387.0 ng L−1) being the most abundant, followed by N,N-diethyl- meta -toluamide (DEET, 9568.4 ng L−1), metoprolol (MTP, 930.2 ng L−1), and diclofenac (DF, 710.3 ng L−1). After treatment processes, the cumulative concentration of PPCPs decreased from 2.54 × 104 ng L−1 to 1.44 × 103 ng L−1, with the overall removal efficiency (RE) of 94.3%. Different treatment processes showed varying contributions in removing PPCPs. PPCPs were efficiently removed in sedimentation, anoxic, and ultraviolet units. For individual compounds, a great variation in RE (52.1–100%) was observed. Twenty-two PPCPs were removed by more than 90%. The highly detected PPCPs in the influent were almost completely removed. Aerated grit chamber removed nearly 50% of fluoroquinolone (FQs) and more than 60% of sulfonamides. Most PPCPs showed low or negative removals during anaerobic treatment, except for CF which was eliminated by 64.9%. Anoxic treatment demonstrated positive removals for most PPCPs, with the exceptions of DF, MTP, bisoprolol, carbamazepine (CBZ), and sibutramine. DEET and bezafibrate were efficiently removed during the secondary sedimentation. Denitrification biological filter and membrane filtration also showed positive effect on most PPCPs removals. The remaining compounds were oxidized by 16–100% in ozonation. DF, sulpiride, ofloxacin (OFL), trimethoprim, and phenolphthalein were not amenable to ultraviolet. After the treatment, the residue OFL, CBZ, and CF in receiving water were identified to pose high risk to aquatic organisms. Considering the complex mixtures emitted into the environment, therapeutic groups psychotropics, stimulant, and FQs were classified as high risk. These findings provide valuable insights into adopting appropriate measures for more efficient PPCPs removals, and emphasize the importance of continued monitoring specific PPCPs and mixtures thereof to safeguard the ecosystem. [Display omitted] • 33 and 23 PPCPs were detected in WWTP influent and effluent, respectively. • The most abundant PPCPs were CF, DEET, MTP, and DF in influent. • A great variation of PPCPs in removal rates was observed from 52.1% to 100%. • Different treatment processes showed variable contribution in removing PPCPs. • The residue OFL, CBZ, and DF in receiving water pose high risks to aquatic life. [ABSTRACT FROM AUTHOR]

The occurrence, eliminations, enantiomeric distribution and intra-day variations of five chiral pharmaceuticals (three beta-blockers and two antidepressants) were investigated in eight major WWTPs in Beijing, China. The results revealed that metoprolol (MTP) and venlafaxine (VFX) were of the highest concentrations among the five determined pharmaceuticals with mean concentrations of 803 ng L −1 and 408 ng L −1 , respectively in influents, and 354 ng L −1 and 165 ng L −1 in effluents, respectively. Their removal efficiencies, intra-day concentration changes and enantiomeric profiles during wastewater treatment were further analyzed. Loads of these two chiral pharmaceuticals were also studied to reveal drug use pattern. A/A/O+MBR (anaerobic/anoxic/oxic + membrane bio-reactor) followed by joint disinfection treatment process exhibited the high removal efficiencies. No or weak enantioselectivity was observed in most WWTPs. However, obvious enantiomeric fraction (EF) changing of MTP was observed in WWTP3 employing A/A/O+MBR. Intra-day concentration fluctuations of MTP were smaller than VFX. A quick response to sudden rise influent concentration of MTP was observed in WWTP1 effluent but EF response lagged behind. Similar bihourly EF variations in influents and effluents were also observed in most WWTPs for MTP and VFX in consideration of hydraulic residence time (HRT). [ABSTRACT FROM AUTHOR]

• First study on enantiomeric occurrence of chiral drugs and metabolites in surface water in China. • NODDV and α-hydroxymetoprolol were for the first time confirmed in domestic water. • The transformation products contributed to 60% of the total load of 11 compounds. • TPs could be transported substantial distances along the river with limited attenuation. • R-venlafaxine was more readily biotransformed than the S-form. The present work aimed to discuss the enantiomeric occurrence of chiral pharmaceuticals including 5 parent compounds (PCs) metoprolol, propranolol, atenolol, venlafaxine and fluoxetine as well as 6 of their transformation products (TPs) in surface water in Beijing. Among which, 9 out of 11 were detected during the two sampling campaigns with N-O -Didesmethylvenlafaxine (NODDV) and α-hydroxymetoprolol confirmed in the catchment for the first time. Metoprolol acid (MTPA) was the most abundant up to 1508 ng L−1, followed by metoprolol and O -desmethylvenlafaxine (ODV). Most compounds showed 100% detection frequency or nearly, while norfluoxetine (the main metabolite of fluoxetine) and 4-hydroxypropranololone (one TP of propranolol) were not detected. Metoprolol (MTP) and venlafaxine (VFX) did not vary significantly between two sampling periods with mean concentrations of 280.7 and 22.9 ng L−1, respectively. Enantiomeric enrichment was observed for venlafaxine, metoprolol and NODDV, where R-venlafaxine was preferentially biotransformed than the S-form through O -desmethylation. Risk assessment indicated that fluoxetine and atenolol could pose harmful effects to aquatic organisms. This work provides enantiospecific profiles of pharmaceutically active compounds (PhACs), and extended the concept of applying the ratio of TPs vs. parent compound plus their enantiomeric traits for quantitative assessment of in situ biodegradation. Due to the considerable contribution by TPs (64% in present study) as well as the unexpected impacts from enantiomeric existence, the stereoselectivity of chiral pollutants during environmental process should be taken into account in future study. To the best of the authors' knowledge, it is the first comprehensive evaluation of chiral pharmaceuticals and transformation products at enantiomeric level in aquatic environment in China, which would facilitate better understanding of their environmental fate. [ABSTRACT FROM AUTHOR]