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To explore the value of different doses of ropivacaine combined with dezocine in patient-controlled epidural analgesia (PCEA) in the application for painless labor. 180 primiparas who planned to give birth naturally in Peking Union Medical College Hospital from January to December in 2019 were selected. According to the method of random remainder, they were divided into group A, B and C, with 60 cases in each group. 0.75% ropivacaine 0.33 mL (2.50 mg), 0.50 mL (3.75 mg), 0.67 mL (5.0 mg) combined with dezocine PCEA for labor analgesia were used respectively. Painless labor was performed when the uterine orifice was opened to 2~3 cm, L2~L3 interstitial puncture, a cephalic tube was placed on the PCEA, PCEA was stopped at the full time of uterine opening. The visual analogue scale (VAS) scores before analgesia (T0), analgesia 15 minutes (T1), full opening (T2), fetal delivery (T3), placental delivery (T4) and sutures Perineum (T5) were compared in the three groups. The modified Bromage score was used to evaluate the effect of lower extremity motor nerve block. The analgesic onset time, the time from the beginning of analgesia to the full opening of the uterine orifice, the first stage of labor, the second stage of labor, and the third stage of labor were counted, and the amount of analgesic drugs used when each group reached the target anesthesia level and the times of pressing the analgesic pump were counted. The amount of postpartum hemorrhage and final delivery methods in each group were recorded, and the neonatal Apgar score method (Apgar) was used to evaluate the neonatal asphyxia, cord blood gas analysis was performed, and the incidence of adverse reactions during delivery of each group was counted. VAS scores of the three groups at T1~T5 time points decreased compared with those of T0 time points (P<0.05), and VAS scores at T1~T5 time points in groups B and C were all lower than those in group A (P<0.05). There was statistical significance in the modified Bromage grading distribution among the three groups (P<0.05). The onset time of analgesia in group B, C was faster than that in group A and the time of the second stage of labor and the third stage of labor in group B, C was shorter than that in group A, the amount of analgesic drugs used when each group reached the target anesthesia level, the times of pressing the analgesic pump and the times of effective pressing were all reduced compared with those of group A (P<0.05), and there were no statistically significant difference in the above indicators between group B and group C (P>0.05). There were no statistically significant differences in the amount of postpartum hemorrhage, final delivery methods, Apgar scores at 1min and 5min after birth, pH value, blood oxygen partial pressure (PO2), carbon dioxide partial pressure (PCO2) and the incidence rate of adverse reactions in the three groups (P>0.05). 0.75% ropivacaine 0.50 mL (3.75 mg) combined with dezocine PCEA has satisfactory analgesic effect in painless labor, little effect on labor process, uterine contraction, mother and child, has the advantages of separation of motor nerve block and sensory nerve block, with less adverse reactions and has a high safety. [ABSTRACT FROM AUTHOR]