1. [The Role of Neurotrophins and Neurexins Genes in the Risk of Paranoid Schizophrenia in Russians and Tatars].
- Author
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Gareeva AE, Traks T, Koks S, and Khusnutdinova EK
- Subjects
- Adult, Bashkiria ethnology, Brain-Derived Neurotrophic Factor genetics, Calcium-Binding Proteins, Case-Control Studies, Cell Adhesion Molecules, Neuronal genetics, Ethnicity, Female, Genetic Predisposition to Disease, Glycoproteins genetics, Humans, Male, Membrane Glycoproteins genetics, Nerve Growth Factor genetics, Nerve Tissue Proteins genetics, Neural Cell Adhesion Molecules, Neuropeptides genetics, Protein-Tyrosine Kinases genetics, Receptor, trkB, Receptor, trkC genetics, Schizophrenia, Paranoid ethnology, Nerve Growth Factors genetics, Polymorphism, Single Nucleotide, Schizophrenia, Paranoid genetics
- Abstract
Schizophrenia affects about 1% of the population. Its etiology is not fully understood. Environmental conditions certainly contribute to the development of schizophrenia, but the determining factor is genetic predisposition: the coefficient of heritability of schizophrenia is about 80%, which is typical for the most highly heritable multifactorial diseases. Polymorphic loci of genes of enzymes and receptors involved in the processes of neuroprotection and neurotrophia play significant role in the development of this disease. In this paper we investigated 48 polymorphic variants of genes of the neurotrophins and neurexins family (BDNF, NTRK2, NTRK3, NGF, NXPH1, and NRXN1) in Russian and Tatar cases and in a control group living in the Republic of Bashkortostan. The results of this study confirm the important role of neurotrophin and neurexin genes in paranoid schizophrenia development.
- Published
- 2015