1. Evaluation of Antibiotic Resistance of Helicobacter pylori Strains Isolated in Bari, Southern Italy, in 2017–2018 by Phenotypic and Genotyping Methods.
- Author
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Palmitessa, Valeria, Monno, Rosa, Panarese, Alba, Cuppone, Renato, Burattini, Osvaldo, Marangi, Stefania, Curlo, Margherita, Fumarola, Luciana, Petrosillo, Antonella, Parisi, Antonio, Capozzi, Loredana, Bianco, Angelica, and Lippolis, Antonio
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HELICOBACTER pylori , *DRUG resistance in bacteria , *HELICOBACTER pylori infections , *GENETIC mutation , *LOCAL knowledge - Abstract
Objective: Helicobacter pylori antibiotic resistance is a constantly evolving process and local surveillance is warranted to guide clinicians in the choice of therapy. Materials and Methods: Antibiotic susceptibility testing was performed by E-test on 92 H. pylori strains, and resistance to clarithromycin and levofloxacin was also evaluated using a commercially available genotyping method. Results: In naïve patients the resistance to clarithromycin, levofloxacin, and metronidazole was 37.7%, 26.2%, and 16.4%, respectively, significantly lower than the percentage found in treated patients. Concomitant resistance to ≥2 antibiotics was also observed in naïve patients. The A2143G mutation of the 23S-rRNA gene was the most frequently detected, also in naïve patients. The highest minimum inhibitory concentration (MIC)50 value (256 mg/L) was associated with A2142 mutations in all the patients carrying them. For levofloxacin resistance a mutation in codon 87 was detected in 63.9% and in codon 91 in 36.1% of the H. pylori strains, without significant differences in the patients groups. A mutation in codon 87 was associated with the highest MIC50 value (32 mg/L). Conclusions: In our area, a high prevalence of H. pylori primary resistance was detected; these rates were higher in patients who had experienced failure of several courses of therapy. A better knowledge of the local epidemiology of resistance, and the genotypes responsible, will improve the H. pylori eradication rates. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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