1. Immune responses following killed whole vibrio-B subunit oral cholera vaccine in human volunteers.
- Author
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Pitisuttithum P, Migasena S, Suntharasamai P, Supanaranond W, Desakorn V, and Prayurahong B
- Subjects
- Administration, Oral, Adult, Antibodies, Bacterial analysis, Bangladesh epidemiology, Cholera epidemiology, Cholera prevention & control, Humans, Immunoglobulin G analysis, Vaccines, Inactivated administration & dosage, Cholera immunology, Cholera Vaccines administration & dosage
- Abstract
Immunogenicity of killed whole vibrio and B subunit oral cholera vaccines in American and Thai volunteers were analysed in terms of significant rise of antibody titre. Three doses of 2 x 10(11) killed vibrios and 5 mg of cholera toxin B subunit were given at two-week intervals. There were no differences in the percent of volunteers with significant rise of serum immunoglobulin G and secretory immunoglobulin A (sIgA) to cholera toxin. However, the percent with significant rises of serum antibody to whole cell V. cholerae Inaba measured by vibriocidal titre and serum immunoglobulin G, and secretory immunoglobulin A to lipopolysaccharide (LPS) measured by ELISA in American volunteers were significantly different from those in Thai volunteers (89% VS 45%, 68% VS 9% and 53% VS 0%, respectively) (p less than 0.05).
- Published
- 1989