1. Frequency of epidermal growth factor receptor mutations in Bangladeshi patients with adenocarcinoma of the lung.
- Author
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Rahman, Shakibur, Kondo, Nobuyuki, Yoneda, Kazue, Takuwa, Teruhisa, Hashimoto, Masaki, Orui, Hayato, Okumura, Yoshitomo, Tanaka, Fumihiro, Kumamoto, Kanako, Mostafa, Mohammad, Chowdhury, Golam, Haque, Akramul, and Hasegawa, Seiki
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EPIDERMAL growth factor receptors , *GENETIC mutation , *ADENOCARCINOMA , *LUNG cancer , *PUBLIC health , *SMOKING , *HEALTH , *PROTEIN-tyrosine kinases - Abstract
Background: Worldwide studies on lung adenocarcinoma have demonstrated a genetic divergence of the epidermal growth factor receptor (EGFR) pathway according to ethnicity, such as higher frequency of activated EGFR mutations among East Asian patients. However, such information is still lacking in some developing countries. Methods: We investigated the frequency of EGFR mutations among Bangladeshi patients with adenocarcinoma of the lung. Fine-needle aspiration tissue samples were collected from 61 Bangladeshi patients. Polymerase chain reaction-single-strand conformation polymorphism was performed on extracted DNA for mutational analysis of EGFR exons 19 and 21. Results: EGFR mutations were found in 14 of 61 (23.0 %) Bangladeshi patients. There was no significant difference in EGFR mutation rate with regard to patient's age, sex, smoking history, clinical stage of lung cancer, subtypes of adenocarcinoma, and tumor differentiation. Conclusion: The present study revealed that the EGFR mutation rate in Bangladeshi patients with adenocarcinoma of the lung was higher than in African-American, Arabian, and white Caucasian patients, and was lower than in East Asia. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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