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Acute coronary syndrome (ACS) is an insufficient supply of oxygenated blood for heart muscle; atherosclerosis is the cause of ischemia of the heart muscle. Some enzymes have a role in atherosclerosis and ACS. Angiotensin-converting enzyme (ACE) and Troponin are the biomarkers associated with (ACS) in Non-ST-segment Elevation Myocardial Infarction (NSTEMI), ST-Elevation Myocardial Infarction (STEMI), and Unstable Angina pectoris (UA) that enhance for detection and treatment. The study samples are included (176) individuals in total, (88) cases with ACS and (88) without ACS. ACS cases are included (50 male, 25 female), (25) cases with STEMI are included (22 male and 3 female), (25) cases of NSTEMI are included (16 male and 9 female) and (25) cases with unstable angina UA are included (12 male and 13 female). After being diagnosed by the cardiologist, all the samples are taken from the Coronary Care Unit (CCU) at Abin Albiater Center For Cardiac Surgery. All the patients were clinically tested by the cardiologist and concentrations of cardiac enzymes by using the electrocardiograph (ECG). The venous blood samples are collected from each patient and controlled after (12) hours fasting between (9-11) A.M. the samples are centrifuged to obtain serum to measure the ACE and Troponin I. Our findings are showed that ACS was significantly decreased as to the control group, while Troponin in the serum was increased in patients with CAD than controls. ACE demonstrated marked changes with the progression of the acute coronary syndrome, and it was valuable in the assessment and detection of ACS and could consideration of ACE as a predictor of ACS. [ABSTRACT FROM AUTHOR]