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This study was aimed to assess total antioxidants capacity as well as interferon γ cytokine in female with Lupus Erythematosus and their relationship with disease activity. Fifty‑two female SLE patients diagnosed and classified according to the American College of Rheumatology (ACR)criteria admitted to Department of Rheumatology at Baghdad and alyarmook teaching hospital. SLE patients were clinically evaluated and disease activity assessed using the SLE indicator and a particular focus on the onset, duration of the disease, and the body organs affected by the disease. Routine laboratory tests were performed for all patients. The levels of serum cytokines and antioxidant capacity were measured by enzyme linked immunosorbent assays (ELISA). In the case of total antioxidant capacity, the result showed that mean values were significantly lower in active lupus patients than inactive lupus and controls (2.050±0.276, 1.322±0.254, 1.286±0.133) respectively, and, the mean of values of interferon γ cytokine in active and inactive SLE patients were significantly higher than control group (83.275±15.612,71.335±14.948,32.049±7.519) respectively. [ABSTRACT FROM AUTHOR]