1. The Significance of Elevated Lactate Dehydrogenase and Creatine Kinase Activities as Prognostic Biomarkers for the Mortality in Patients with Terminal Cancers.
- Author
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AL-Daami, Qasim J., Al-Hindy, Hayder A. A., Kaurshead, Rzaq S., and Abdullah, Rawaa G.
- Subjects
LACTATE dehydrogenase ,CREATINE kinase ,CANCER-related mortality ,PROGNOSIS ,ADULTS ,SURVIVAL analysis (Biometry) - Abstract
Background: Both creatine kinase (CK) and/or lactate dehydrogenase (LDH) mutually are elevated significantly in many tumors. This study hypothesizes that LDH was evaluated as a prognostic factor for survival time in patients with terminal cancer (PTC). Additionally, CK considered as a valuable in assessing prognosis of advanced cancer patients. This study aimed to estimate the change in the CK/LDH levels in patients with different types of cancer comparing with the controls, and to investigate their prognostic significance for survival time termination in PTC. Methodology: The study was performed at Cancer Central Research Clinic in Baghdad. We quantitated CK/ LDH using the colorimetric method in sixty PTC, and twenty age/sex-matched healthy adults. Results: Serum values of CK/LDH were significantly increased in PTC compared to the controls (p<0.001). There was a weak non-significant correlation between CKLDH in PTC and control. There was a non- significant correlation of CK to LDH levels in different cancer types, except in patients with lymphatic cancer. Conclusion: In agreement with our hypothesis, serum levels of CK/LDH were significantly increased as the patients approached death. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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