1. Genetic risk factors and markers for Alzheimer's disease and/or depression in the VITA study.
- Author
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Grünblatt E, Zehetmayer S, Bartl J, Löffler C, Wichart I, Rainer MK, Jungwirth S, Bauer P, Danielczyk W, Tragl KH, Riederer P, and Fischer P
- Subjects
- Aged, Alzheimer Disease epidemiology, Alzheimer Disease physiopathology, Apolipoproteins E genetics, Austria epidemiology, Brain-Derived Neurotrophic Factor genetics, Choline O-Acetyltransferase genetics, Ciliary Neurotrophic Factor genetics, Comorbidity, Depressive Disorder epidemiology, Depressive Disorder physiopathology, Educational Status, Female, Folic Acid blood, Genotype, Humans, Logistic Models, Longitudinal Studies, Male, Receptors, Dopamine D4 genetics, Risk Factors, Serotonin Plasma Membrane Transport Proteins genetics, Sex Factors, Alzheimer Disease genetics, Depressive Disorder genetics, Genetic Predisposition to Disease genetics, Polymorphism, Genetic
- Abstract
Objectives: In ageing population, both Alzheimer's disease (AD) and depression are common. Significant depressive symptoms are often co-morbid with cognitive impairment and dementia. In this study, we attempted to find various factors and markers for both AD and depression in a longitudinal cohort, the Vienna-Transdanube-Aging (VITA)-study., Methods: The VITA-Study consisted of 305 healthy subjects, 174 subjects with depression only, 55 subjects diagnosed with AD only and 72 subjects with depression as well as AD. Associations between AD and/or depression to gene polymorphisms APO E (epsilon4), choline acetyltransferase (ChAT) 4G to A, serotonin-transporter gene promoter-length, dopamine-D4-receptor, ciliary-neurotrophic-factor-null mutation and brain-derived neurotrophic factor (C270T) and to various known factors were analyzed., Results: AD and depression were significant associated. Significant risk factors found for AD were low education, low folic acid and depressive-symptoms, while for depression were low education and higher nonsteroidal anti-inflammatory drugs (NSAID) consume. Moreover, the ChAT polymorphism associated significant to depression. Gender, education, and ChAT significantly associated with the combination AD and/or depression., Conclusion: Such studies must be conducted cautiously, as co-morbidities and gene-environmental-social influences may sway the results dramatically. We found in the VITA-study significant association between depression and AD and between ChAT polymorphism and depression.
- Published
- 2009
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