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Background: Participation in ultra-endurance races may lead to a transient decline in cardiac function and increased cardiovascular biomarkers. This study aims to assess alterations in biventricular function immediately and five days after the competition in relation to elevation of high-sensitivity cardiac Troponin I (hs-cTnI) and N-terminal-pro-brain-natriuretic-peptide (NT-proBNP). Methods and Results: Fifteen participants of an ultramarathon (UM) with a running distance of 130 km were included. Transthoracic echocardiography and quantification of biomarkers was performed before, immediately after and five days after the race. A significant reduction in right ventricular fractional area change (FAC) was observed after the race (48.0 ± 4.6% vs. 46.7 ± 3.8%, p = 0.011) that persisted five days later (48.0 ± 4.6% vs. 46.3 ± 3.9%, p = 0.027). No difference in left ventricular ejection fraction (LVEF) was found (p = 0.510). Upon stratification according to biomarkers, participants with NT-proBNP above the median had a significantly reduced LVEF directly (60.8 ± 3.6% vs. 56.9 ± 4.8%, p = 0.030) and five days after the race (60.8 ± 3.6% vs. 55.3 ± 4.5%, p = 0.007) compared to baseline values. FAC was significantly reduced five days after the race (48.4 ± 5.1 vs. 44.3 ± 3.9, p = 0.044). Athletes with hs-cTnI above the median had a significantly reduced FAC directly after the race (48.1 ± 4.6 vs. 46.5 ± 4.4, p = 0.038), while no difference in LVEF was observed. No alteration in cardiac function was observed if hs-cTnI or NT-proBNP was below the median. Conclusion: A slight decline in cardiac function after prolonged strenuous exercise was observed in athletes with an elevation of hs-cTnI and NT-proBNP above the median but not below. Key Findings: Participation in an ultra-endurance marathon with a running distance of 130 km is associated with a transient decline in cardiac function in those athletes with markedly increased N-terminal pro-brain natriuretic peptide and high-sensitivity cardiac troponin I after the race. This alteration in cardiac function is not found in athletes with only a minor elevation of these biomarkers. [ABSTRACT FROM AUTHOR]

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We present a test of Coasean theories of efficient separations. We study a cohort of jobs from the introduction through the repeal of a large age- and region-specific unemployment benefit extension in Austria. In the treatment group, 18.5 |$\%$| fewer jobs survive the program period. According to the Coasean view, the destroyed marginal jobs had low joint surplus. Hence, after the repeal, the treatment survivors should be more resilient than the ineligible control group survivors. Strikingly, the two groups instead exhibit identical post-repeal separation behaviour. We provide, and find suggestive evidence consistent with, an alternative model in which wage rigidity drives the inefficient separation dynamics. [ABSTRACT FROM AUTHOR]

Background and purpose: Hereditary myopathies with limb‐girdle muscular weakness (LGW) are a genetically heterogeneous group of disorders, in which molecular diagnosis remains challenging. Our aim was to present a detailed clinical and genetic characterization of a large cohort of patients with LGW. Methods: This nationwide cohort study included patients with LGW suspected to be associated with hereditary myopathies. Parameters associated with specific genetic aetiologies were evaluated, and we further assessed how they predicted the detection of causative variants by conducting genetic analyses. Results: Molecular diagnoses were identified in 62.0% (75/121) of the cohort, with a higher proportion of patients diagnosed by next‐generation sequencing (NGS) than by single‐gene testing (77.3% vs. 22.7% of solved cases). The median (interquartile range) time from onset to genetic diagnosis was 8.9 (3.7–19.9) and 17.8 (7.9–27.8) years for single‐gene testing and NGS, respectively. The most common diagnoses were myopathies associated with variants in CAPN3 (n = 9), FKRP (n = 9), ANO5 (n = 8), DYSF (n = 8) and SGCA (n = 5), which together accounted for 32.2% of the cohort. Younger age at disease onset (p = 0.043), >10× elevated creatine kinase activity levels (p = 0.024) and myopathic electromyography findings (p = 0.007) were significantly associated with the detection of causative variants. Conclusions: Our findings suggest that an earlier use of NGS in patients with LGW is needed to avoid long diagnostic delays. We further present parameters predictive of a molecular diagnosis that may help to select patients for genetic analyses, especially in centres with limited access to sequencing. [ABSTRACT FROM AUTHOR]

Background With the coronavirus disease 2019 (COVID-19) pandemic surging and new mutations evolving, trust in vaccines is essential. Methods We explored correlates of vaccine hesitancy, considering political believes and psychosocial concepts, conducting a non-probability quota-sampled online survey with 1007 Austrians. Results We identified several important correlates of vaccine hesitancy, ranging from demographics to complex factors such as voting behavior or trust in the government. Among those with hesitancy towards a COVID-19 vaccine, having voted for opposition parties (opp) or not voted (novote) were (95% Confidence Intervall (CI)opp, 1.44–2.95) to 2.25-times (95%CInovote, 1.53–3.30) that of having voted for governing parties. Only 46.2% trusted the Austrian government to provide safe vaccines, and 80.7% requested independent scientific evaluations regarding vaccine safety to increase willingness to vaccine. Conclusions Contrary to expected, psychosocial dimensions were only weakly correlated with vaccine hesitancy. However, the strong correlation between distrust in the vaccine and distrust in authorities suggests a common cause of disengagement from public discourse. [ABSTRACT FROM AUTHOR]

Simple Summary: In the last years several alien mosquito species have been introduced into Austria. Those species pose a threat, as they—especially the Asian tiger mosquito (Aedes albopictus)—can transmit many pathogens. The aim of this study is a nationwide overview on the situation of alien mosquitoes in Austria. Using traps representing ideal breeding sites for those mosquitoes, we collected, counted and identified the species of the mosquito eggs laid in the traps. The Asian tiger mosquito was found at two sites, once in Tyrol, where this species has been reported before, and for the first time in the province of Lower Austria. The Asian bush mosquito (Aedes japonicus) was widespread and abundant in Austria. Although it was found in all provinces, the Asian bush mosquito was more often found in the South than the North and more eggs were collected in urban/industrial/transport areas than in (mostly) natural areas. Further, more eggs from the Asian bush mosquito were found in samples collected at higher daily mean temperatures, and fewer eggs in samples collected at higher daily maximum wind speeds. The results of this study will help to better understand the risk from alien mosquitoes to human health in Austria and will be useful to show future changes in the distribution of those species. In Austria, only fragmented information on the occurrence of alien and potentially invasive mosquito species exists. The aim of this study is a nationwide overview on the situation of those mosquitoes in Austria. Using a nationwide uniform protocol for the first time, mosquito eggs were sampled with ovitraps at 45 locations in Austria at weekly intervals from May to October 2020. The sampled eggs were counted and the species were identified by genetic analysis. The Asian tiger mosquito Aedes albopictus was found at two sites, once in Tyrol, where this species has been reported before, and for the first time in the province of Lower Austria, at a motorway rest stop. The Asian bush mosquito Aedes japonicus was widespread in Austria. It was found in all provinces and was the most abundant species in the ovitraps by far. Aedes japonicus was more abundant in the South than in the North and more eggs were found in habitats with artificial surfaces than in (semi-) natural areas. Further, the number of Ae. japonicus eggs increased with higher ambient temperature and decreased with higher wind speed. The results of this study will contribute to a better estimation of the risk of mosquito-borne disease in Austria and will be a useful baseline for a future documentation of changes in the distribution of those species. [ABSTRACT FROM AUTHOR]

Objectives: To explore changes in quality of life and perceived productivity, focusing on the effects of working from home during the first COVID-19 50-day mitigation period in Austria. Methods: We conducted an Austrian-representative online survey (N = 1010) of self-reported life- and work-related changes during the first COVID-19 50-day mitigation period (March 16 through May 1 2020) compared to the situation before. We used multinominal logistic regression models to identify correlates of improved/decreased quality of life in the entire sample, and of improved/decreased productivity in a subsample of the working population (N = 686). We also calculated age- and multivariable-adjusted ORs and 95% CIs of an improved/decreased quality of life and an improved/decreased productivity by work from home status. Results: During the COVID-19 mitigation period, quality of life improved in 17.5%, but decreased in 20.7% of the general Austrian population; perceived productivity at work increased in 12.7%, but decreased in 30.2% of the working population. Working from home during the mitigation period was associated with an increased quality of life (vs. none, partially: OR 2.07, 95% CI 1.09–3.91; all the time: 3.69, 1.86–7.29). In contrast, perceived productivity seemed to decrease when people worked from home (vs. none, partially: 1.42, 0.86–2.35; all the time: 1.48, 0.85–2.58). Working from home and related benefits were not equally distributed among gender, age, and educational attainment. Conclusions: A transition to more flexibility of workplace and working hours for employees could have important positive consequences for family and professional life, for stakeholders, for public health, and ultimately for the environment. [ABSTRACT FROM AUTHOR]

Purpose: Global food production needs to increase to provide enough food for over 9 billion people living by 2050. Traditional animal production is among the leading causes for climate change and occupation of land. Edible insects might be a sustainable protein supply to humans, but environmental life cycle assessment (LCA) studies on them are scarce. This study performs an LCA of a small-scale production system of yellow mealworms (Tenebrio molitor) in Central Europe that are supplied with organic feedstuff. Methods: A combined ReCiPe midpoint (H) and CED method is used to estimate the potential environmental impacts from cradle-to-gate. Impact categories include global warming potential (GWP), non-renewable energy use (NREU), agricultural land occupation (ALOP), terrestrial acidification potential (TAP) and freshwater eutrophication potential (FEP). The robustness of the results is tested via sensitivity analyses and Monte Carlo simulations. Results and discussion: Impacts related to the production of 1 kg of edible mealworm protein amount to 20.4 kg CO2-eq (GWP), 213.66 MJ-eq (NREU), 22.38 m2 (ALOP), 159.52 g SO2-eq (TAP) and 12.41 g P-eq (FEP). Upstream feed production and on-farm energy demand related to the heating of the facilities are identified as environmental hot-spots: Depending on the impact category, feed supply contributes up to 90% and on-farm heating accounts for up to 65% of overall impacts. The organic mealworm production system is contrasted with a selected Austrian organic broiler production system, to which it compares favourably (18–72% lower impacts per category), with the exception of freshwater eutrophication (6% higher impacts). Conclusions: This case study shows that the Austrian mealworm production system compares favourably to traditional livestock systems. Compared to LCAs from large-scale T. molitor rearing facilities in France and in the Netherlands, however, the Austrian production system cannot compete for the reasons of production scale, feed conversion efficiency and type of production system. Nevertheless, the investigated mealworms represent a sustainable protein alternative that should be added to the Western diet. [ABSTRACT FROM AUTHOR]

Recent research suggests that new technologies are important drivers of empirically observed labour market polarisation. Many analyses in the field of economics are conducted to evaluate the changing share of employment in low-skill, medium-skill and high-skill occupations over time. This occupation-based approach, however, may neglect the relevance of specific skills and skill bundles, which potentially can be used to explain the observable patterns of labour market polarisation. This paper adds to the literature in two ways: First, we present the results of an analysis of data on job vacancies rather than the currently employed and, second, we derive occupation-defining skills using network analysis tools. The analysis and tool usage allowed us to investigate polarisation patterns in Austrian vacancy data from 2007 to 2017 and identify changes in the skills demanded in job vacancies in Austria. In contrast to most previous research, we find no evidence for polarisation, but rather a trend towards upskilling. [ABSTRACT FROM AUTHOR]

Nonemployment is often posited as a worker's outside option in wage-setting models such as bargaining and wage posting. The value of nonemployment is therefore a key determinant of wages. We measure the wage effect of changes in the value of nonemployment among initially employed workers. Our quasi-experimental variation in the value of nonemployment arises from four large reforms of unemployment insurance (UI) benefit levels in Austria. We document that wages are insensitive to UI benefit changes: point estimates imply a wage response of less than $0.01 per $1.00 UI benefit increase, and we can reject sensitivities larger than $0.03. The insensitivity holds even among workers with low wages and high predicted unemployment duration, and among job switchers hired out of unemployment. The insensitivity of wages to the nonemployment value presents a puzzle to the widely used Nash bargaining model, which predicts a sensitivity of $0.24–$0.48. Our evidence supports wage-setting models that insulate wages from the value of nonemployment. [ABSTRACT FROM AUTHOR]

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disease characterized by a deregulated complement system, chronic Coombs-negative, intravascular hemolysis, and a variable clinical course with substantial risk to develop thromboembolic events. We analyzed diagnostic and prognostic parameters as well as clinical endpoints in 59 adult patients suffering from PNH in 5 hematology centers in Austria (observation period: 1978–2015). Median follow-up time was 5.6 years. The median clone size at diagnosis amounted to 55% and was higher in patients with classical PNH (81%) compared to patients with PNH associated with aplastic anemia (AA) or myelodysplastic syndromes (MDS) (50%). The clone size also correlated with lactate dehydrogenase (LDH) levels. In one patient, anemia improved spontaneously and disappeared with complete normalization of LDH after 16 years. Seventeen patients received therapy with eculizumab. The rate of thromboembolic events was higher in the pre-eculizumab era compared with eculizumab-treated patients but did not correlate with the presence of age-related clonal hematopoiesis or any other clinical or laboratory parameters. Peripheral blood colony-forming progenitor cell counts were lower in PNH patients compared with healthy controls. Only two patients with classical PNH developed MDS. Overall, 7/59 patients died after 0.5–32 years. Causes of death were acute pulmonary hypertension, Budd-Chiari syndrome, and septicemia. Overall survival (OS) was mainly influenced by age and was similar to OS measured in an age-matched healthy Austrian control cohort. Together, compared with previous times, the clinical course and OS in PNH are favorable, which may be due to better diagnosis, early recognition, and eculizumab therapy. [ABSTRACT FROM AUTHOR]

What is known and objective Ibrutinib is inhibiting the Bruton's tyrosine kinase (BTK), thereby influencing B-cell development. We describe an unexpected side effect of ibrutinib in two patients with chronic lymphocytic leukaemia concerning the vigorous decrease of two different diabetes-associated antibodies. Case description Two weeks after onset of ibrutinib therapy, patient A frequently noticed symptoms of hypoglycaemia such as dizziness and blurred vision. Blood glucose declined to 35-40 mg/dL. He had to lower his insulin dose step by step. High levels of insulin antibodies which had developed during insulin therapy were detected. Seven weeks after start of ibrutinib, his insulin antibodies level had dropped by 54.6%. Patient B had a 54.1% decrease in his glutamic acid decarboxylase autoantibodies level after 7 weeks. What is new and Conclusion The inhibitory effect of ibrutinib on the levels of insulin antibodies and glutamic acid decarboxylase autoantibodies is a novel finding and may have implications for diabetes care. [ABSTRACT FROM AUTHOR]

Background Several studies have shown contradictive findings regarding mortality and hospital admission time in patients presenting with ST-elevation myocardial infarction (STEMI). The aim of this study was to assess the impact of “on-” or “off-hour” admission on short- and long-term all-cause mortality of patients in the advanced Vienna STEMI network between 2003 and 2009. Methods and results In total, 2829 patients were included into this analysis. Patients were stratified according to admission time into “on-hour” admission (07:30 until 15:00 h on weekdays) and “off-hour” admission (15:00–7:30 h on weekdays and 24 h on weekends). As endpoint of interest, all-cause mortality was investigated after 30 days and 3 years of follow-up, the latter for all patients and as Landmark analysis for survivors of the index event. Mean age was 60.5 ± 13.3 years, 2048 (72.4%) patients were male and 1260 (44.5%) patients presented with anterior wall infarction. 683 (24.1%) patients were admitted “on-hours”, 2146 (75.9%) patients were admitted “off-hours”. All-cause death occurred in 176 (6.2%) patients after a follow-up of 30 days and in 337 (11.9%) patients after 3 years. For short- and long-term all-cause mortality no significant differences could be detected between “on-” and “off-hour” admission in univariate and multivariate Cox proportional hazard analyses as well as for propensity score adjusted outcome analysis. Conclusion In the Vienna STEMI network, “on-” or “off-hour” admission had no impact on short- and long-term mortality for all-comers presenting with acute STEMI. Our findings confirm the imperative need for well-structured STEMI networks of care, as previous data repeatedly demonstrated increased adverse cardiovascular outcome for “off-hour” admission. [ABSTRACT FROM AUTHOR]

The abrasion response of cross sectional areas of enamel was studied by sliding a rounded diamond conical nano-indenter tip across the surface. The nano-indenter tip (radius ~1,200 nm) was scanned over a specific squared area with a load of 400 μN. Two different environments were chosen: Hank’s balanced salt solution (HBSS) and atmospheric laboratory condition. SEM (Scanning Electron Microscopy) and AFM (Atomic Force Microscopy) were used to characterize the final abraded areas. In addition, single scratches with linear incremented load were performed. The normal load and displacement data were utilized in a complementary manner to support the proposed deformation mechanisms. Greater orientation dependence for the case of the single scratches in relation to the abrasion tests was found. The latter results are discussed in terms of plastic deformation effects. The abrasion mechanisms were found to be the same for both wet and dry measurements and similar to that described in a previous study (Guidoni et al., Wear 266:60–68, ; Guidoni, Nano-scale mechanical and tribological properties of mineralized tissues. PhD. Montan University Leoben, Leoben, Austria, ). However, scratch deformation under fluid measurements shows greater recovery effects and abrasion resistance. [ABSTRACT FROM AUTHOR]

Abstract: Numerous studies have analyzed the carbon sequestration potential of forests and forest management. However, most studies either focused on national and supra-national scales or on the project level in the context of the flexible mechanisms of the Kyoto Protocol. Few studies are available which analyze the effects of alternative silvicultural strategies on carbon sequestration, timber production and other forest services and functions at the operational level of the forest management unit (FMU). The present study investigates effects of three alternative management strategies for secondary Norway spruce forests (Picea abies (L.) Karst.) (Norway spruce age class forestry; continuous cover forestry; conversion to mixed broadleaved forests) and an unmanaged control variant on C sequestration in situ, in wood products and through bioenergy production at the level of a private FMU in Austria, and analyses the interrelationships with timber production and key indicators of biodiversity. The hybrid patch model PICUS v1.4 and a wood products model are employed to simulate forest ecosystem development, timber production, carbon storage in the forest and in wood product pools. Results show that in situ C sequestration is sensitive to forest management with the highest amount of carbon stored in the unmanaged strategy, followed by the continuous cover regime. All three management strategies store substantial quantities of C in the wood products pool. Considering alternative biomass utilization focused on bioenergy production, substantial C offsets could be generated from potential substitution of fossil fuels. Opportunity cost estimates for C sequestration reveal that C sequestration through forest management can be a cost efficient way to reduce atmospheric CO2, but the achievable quantities are limited due to biological limitations and societal constraints. The study emphasizes the importance of developing sustainable forest management strategies that serve the multiple demands on forests in the future. [Copyright &y& Elsevier]

Stock density indices are numerical population descriptors derived from length-frequency data and has been mostly applied to North American sport fish populations to define the structure of the population. Traditional relative-stock-density and proportional-stock-density-indices were applied to Arctic charr, Salvelinus alpinus (L.) populations of five alpine and three prealpine Austrian lakes. Biological parameters of asymptotic size and size at maturity were used to define the length categories for the index calculation specifically for the lakes under study. We tested both, a ‘traditional approach’ and a ‘lake specific approach’. The results showed that the ‘lake specific approach’ provided a better insight to population structures of landlocked Arctic charr populations. In contrast, the ‘traditional approach’ gave an uninformative description of the population structures. Advantages and disadvantages of the techniques, applications and the results of the study lakes are discussed. [ABSTRACT FROM AUTHOR]

After decades of corporatist urban governance dominated by social democracy, Vienna is undergoing a process of economic and political restructuring. This process is expressed physically in large urban development projects, Donau City being the most important. Donau City is a large real estate project on the left bank of the Danube, based on public- private partnership. Due to the liberalization of the housing market, new private actors are increasingly important, influencing decision-making in the Donau City project. In urban planning in general, growing interest in real estate investment has resulted in new planning procedures incorrectly labelled as bottom-up. In fact, this is a fragmented, privatized, opaque and ad hoc form of urban governance accompanied by a new elitist hierarchy formed by leaders of the city's administration, business and academic worlds. This new, unaccountable elite has elaborated a strategic plan for Vienna with little reference to the citizenry. Therefore, the new liberal form of governance goes hand in hand with important continuities concerning co-optation, exclusion and conflict avoidance. The article ends by stressing the importance of alternative political projects that aim at participatory democracy overcoming deep-rooted authoritarian structures. [ABSTRACT FROM AUTHOR]

Background: The role of ash (Fraxinus excelsior) pollen as a cause of spring pollinosis in central Europe has received little attention. It is not clear whether ash pollen is a primary cause of sensitization or whether it is implicated through cross-sensitization to other pollens. Methods: Over a 22-month period, ash pollen was included in a screening series for inhalant allergies. Pollen data were documented from 1976 through 1999. The frequency of IgE-binding to the ash-specific allergen Fra e 1 and pollen panallergens, respectively, was compared by Western blot between mono- (n=6), oligo- (n=16), and polysensitized (n=25) patients. Results: Of 5416 consecutive patients sensitized to any pollen, 920 (17.6%) had a positive skin prick test to ash. Total pollen counts varied extensively between years (229–5351) as did peak concentrations (23–837 grains/m3/24 h). Western blotting revealed Fra e 1 sensitization in 100% of monosensitized, 93% of oligosensitized, but only 44% of polysensitized patients. IgE against profilins (Fra e 2), Ca-binding proteins (Fra e 3), and carbohydrate epitopes in the three groups was found in 0/0/17%, 0/19/31%, and 32/72/60%, respectively. At least 50% of sera from patients with Fra e 1 sensitization did not bind with the protein in Western blots under reducing conditions. Conclusions: Ash pollen should be considered a relevant factor and distinct entity in spring pollinosis. In all, only 20% of positive skin tests to ash appear to result from cross-sensitization to pollen panallergens. [ABSTRACT FROM AUTHOR]

Focuses on the water management and limnological research in Austria. Investigation of the ecological integrity; Assessment of the ecological status of running waters; Analysis of water quality.