1. A cross-sectional study of elderly Asian and European women with primary operable breast cancer aged 70 and older. Are there differences?
- Author
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Tea MK, Tang L, Di GH, Muin D, Steurer S, Delancey JW, Shao ZM, and Singer CF
- Subjects
- Aged, Aged, 80 and over, Asia, Austria, Breast Neoplasms metabolism, Breast Neoplasms pathology, Chi-Square Distribution, Female, Humans, Lymph Nodes, Receptor, ErbB-2 metabolism, Asian People, Breast Neoplasms ethnology, Receptors, Estrogen metabolism, White People
- Abstract
Background: Breast cancer (BC) is becoming a disease of the elderly. Additionally, BC-incidence is rising in Asia. The aim of this study was to explore clinico-pathological characteristics and differences of breast cancer in elderly Asian/Han-Chinese compared to Caucasian/Austrian women., Methods: A total number of 630 consecutive primary operable, unilateral breast cancer cases, 70 years and older, were analyzed. Histo-pathological findings and biological characteristics of 198 Caucasian/Austrian were compared with 432 Asian/Han-Chinese. Pearson's chi-square test was used to assess differences in the analyzed populations., Results: A significantly higher rate of triple-negative BC (p=0.027) was diagnosed among the Chinese geriatric population. More estrogen-receptor positive BC was detected in the Caucasian study group (p<0.001). No statistically significant differences were detected based on tumor size, axillary lymph-node status, nor HER2-receptor expression., Conclusion: This study will help us gain additional ethnic-specific insight into the biological characteristics of breast cancer in the elderly Caucasian/Austrian and Asian/Han-Chinese populations., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2012
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