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The Eremophila plant family, which occurs in the arid zones of Australia, have witnessed extensive investigation, mostly inspired by Aboriginal traditional medicine. A wide and varied biological and phytochemical profile has been reported for over 18 individual species of Australian Eremophila , although E. macdonnellii from the Simpson Desert has not yet been investigated. Isolation and elucidation of one new and six known furofuran lignans are reported. The new lignan, epimethoxypiperitol, displayed moderate anti-cancer activity against the breast cancer cell line (MCF-7). [ABSTRACT FROM AUTHOR]

Two novel seco-casbanes EBC-328 (I) and EBC-363 (II) from the australian rainforest plant Croton insularis. [ABSTRACT FROM AUTHOR]

The article studies the structure and stereochemistry of the anticancer agent, EBC-23, from the Australian rainforest. According to the authors, the deduced structure of the prostate anticancer agent 2 has been completely matched in terms of bond connectivity and relative and absolute stereochemistry. The authors add that total synthesis further demonstrated the value of linchpin technology.