6 results on '"Varghese, Daniel"'
Search Results
2. The Association between Physical Health and Delusional-Like Experiences: A General Population Study.
- Author
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Saha, Sukanta, Scott, James, Varghese, Daniel, and McGrath, John
- Subjects
PHYSICAL fitness & genetics ,PSYCHOTIC depression ,ANXIETY disorders ,PHYSICAL fitness ,COMORBIDITY ,HEALTH surveys ,MENTAL health - Abstract
Objective: Delusional-like experiences (DLE) are prevalent in the community. Recent community based studies have found that DLE are more common in those with depression and anxiety disorders, and in those with subclinical symptoms of depression and anxiety. Chronic physical disorders are associated with comorbid depression and anxiety; however, there is a lack of evidence about the association of DLE with common physical conditions. The aim of this study was to explore associations between the common physical disorders and DLE using a large population sample. Methods: Subjects were drawn from the Australian National Survey of Mental Health and Wellbeing 2007, a national household survey of 8841 residents aged between 16 and 85 years. The presence of DLE, selected common physical disorders and symptoms were assessed using a modified World Mental Health Composite International Diagnostic Interview (CIDI) schedule. We examined the relationship between DLE, and physical health-related variables using logistic regression, with adjustments for potential confounding factors. Results: Of the 8771, 776 (8.4%) subjects positively endorsed one or more DLE. Of the six physical disorders examined, only diabetes and arthritis were significantly associated with the endorsement of DLE. Of the seven broad physical symptoms explored, only hearing problems were consistently associated with DLE. Conclusion: Delusional-like experiences are common in the Australian community, and are associated with selected chronic physical disorders and with impaired hearing. The direction of causality between these variables warrants closer research scrutiny. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
3. Clozapine in the community: Improved access or risky free-for-all?
- Author
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Winckel K, Siskind D, Hollingworth S, Robinson G, Mitchell S, Varghese D, Smith L, and Wheeler AJ
- Subjects
- Australia, Humans, Antipsychotic Agents therapeutic use, Clozapine therapeutic use, Drug Prescriptions, Pharmacies organization & administration
- Published
- 2015
- Full Text
- View/download PDF
4. The association between delusional-like experiences and suicidal thoughts and behaviour.
- Author
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Saha S, Scott JG, Johnston AK, Slade TN, Varghese D, Carter GL, and McGrath JJ
- Subjects
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Australia, Catchment Area, Health, Diagnostic and Statistical Manual of Mental Disorders, Female, Health Surveys, Humans, Male, Middle Aged, Risk Factors, Severity of Illness Index, Sex Distribution, Young Adult, Delusions epidemiology, Delusions psychology, Suicidal Ideation
- Abstract
Background: Delusional-like experiences (DLEs) are common in the general population. Whilst it is well known that psychotic disorders increase the risk of suicide, it is unclear if DLEs are also associated with suicidal thoughts and behaviour. This study aims to explore these variables in a large population-based sample., Method: Participants were drawn from a national survey of mental health (n=8841) in Australia. The Composite International Diagnostic Interview was used to identify DLEs, psychiatric disorders, and information related to suicidal ideation, suicide plan and suicide attempts. We examined the relationship between DLEs and suicidal ideation, plans and attempts using logistic regression, adjusted for a range of potentially confounding variables., Results: 8.4% of subjects endorsed one or more DLEs. 12.9% subjects reported suicidal ideation, 3.8% suicidal plans, and 3.0% a suicide attempt at some point in their lives. Those with any DLE were about two to four times as likely to report suicidal ideation, plans or attempts. There was a dose response relationship between DLEs and endorsement of suicide-related items., Conclusions: DLEs are common in the general population and appear to be independently associated with suicidal thoughts and behaviour. DLE may provide a marker of vulnerability to suicide, and thus could be of value in future suicide prevention research., (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
5. The association between family history of mental disorder and delusional-like experiences: a general population study.
- Author
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Varghese D, Saha S, Scott JD, Chan RC, and McGrath JJ
- Subjects
- Australia epidemiology, Depression, Humans, Schizophrenia, Delusions etiology, Family, Mental Disorders epidemiology
- Abstract
Recent studies have indicated that isolated delusional-like experiences (DLE) are common in the general population. Furthermore, there is preliminary evidence to suggest that these experiences are more common in those with a family history of mental disorders. We had the opportunity to explore the association between family history of a wide range of mental disorders and DLE in an Australian general population survey. The Australian National Survey of Mental Health and Wellbeing 2007 examined 8,841 adult community residents. The Composite International Diagnostic Interview was used to generate various DSM-IV lifetime diagnoses and to assess DLE. The participants were asked to report mental disorders in their first-degree relatives. The influence of family history of mental disorders on DLE endorsement was assessed with logistic regression, with adjustments for age, sex, and the presence of comorbid psychiatric diagnoses in the respondents. A family history of anxiety, depression, schizophrenia, bipolar disorder, or alcohol or illicit drug abuse/dependence was each significantly associated with endorsement of DLE, and these associations remained significant when we adjusted for the presence of mental illness in the respondents. When we examined a more restrictive definition of DLE, only a family history of depression and schizophrenia remained significantly associated with DLE. DLE are associated with a family history of a wide range of mental disorders. These findings suggest that familial factors associated with DLE may be shared with a wide range of common mental disorders., (Copyright © 2011 Wiley-Liss, Inc.)
- Published
- 2011
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- View/download PDF
6. Correlates of delusion-like experiences in a non-psychotic community sample.
- Author
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Varghese D, Scott J, and McGrath J
- Subjects
- Adolescent, Adult, Age Distribution, Aged, Australia epidemiology, Case-Control Studies, Female, Genetic Predisposition to Disease psychology, Health Surveys, Humans, Male, Middle Aged, Paternal Age, Residence Characteristics statistics & numerical data, Risk Factors, Sex Distribution, Surveys and Questionnaires, Transients and Migrants psychology, Transients and Migrants statistics & numerical data, Delusions epidemiology, Delusions psychology
- Abstract
Objective: Several large population-based studies have reported that otherwise-well individuals endorse items related to delusion-like experiences. The aim of the present study was to examine selected correlates of delusion-like experiences in a sample of non-psychotic individuals., Method: Subjects (n=310) were screened with the Diagnostic Interview for Psychosis in order to exclude psychotic disorders. Delusion-like experiences were assessed with the Peters Delusional Inventory (PDI). Non-parametric statistics were used to assess the relationship between total PDI score and a range of demographic (age, sex, migrant status, paternal age), physical (minor physical anomalies) symptom-related variables (hallucinations, awareness of thought disorder) and family history of mental illness., Results: The median (range) PDI score was 4 (0-26), while one-third of the subjects endorsed seven or more items. The presence of a family history of any psychiatric condition was significantly correlated with a higher PDI score. PDI score was significantly positively correlated with endorsement of hallucinations and awareness of thought disorder. PDI was not significantly associated with sex, family history of schizophrenia, paternal age, migrant status nor scores related to minor physical anomalies. There was a trend level association between younger age and higher PDI score., Conclusion: Delusion-like experiences are relatively common in non-psychotic individuals. The association with a family history of mental disorders provides clues to the mechanisms underlying the profile of delusion-like experience.
- Published
- 2008
- Full Text
- View/download PDF
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